Hot-Melt Granulation in a Twin Screw Extruder: Effects of Processing on Formulations with Caffeine and Ibuprofen

2013 ◽  
Vol 102 (12) ◽  
pp. 4330-4336 ◽  
Author(s):  
Sharleen Weatherley ◽  
B.O. MU ◽  
Michael R. Thompson ◽  
Paul J. Sheskey ◽  
Kevin P. O'Donnell
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Hot Melt Granulation ◽  
Hot Melt ◽  
Melt Granulation

Application of Melt Granulation Technology Using Twin-screw Extruder in Development of High-dose Modified-Release Tablet Formulation

2011 ◽  
Vol 100 (5) ◽  
pp. 1923-1934 ◽  
Author(s):  
Madhav Vasanthavada ◽  
Yanfeng Wang ◽  
Thomas Haefele ◽  
Jay P. Lakshman ◽  
Manisha Mone ◽  
...  
Keyword(s):  
Tablet Formulation ◽  
High Dose ◽  
Twin Screw Extruder ◽  
Modified Release ◽  
Screw Extruder ◽  
Twin Screw ◽  
Granulation Technology ◽  
Melt Granulation ◽  
Release Tablet

Experimental characterization and modeling of twin-screw extruder elements for pharmaceutical hot melt extrusion

AIChE Journal ◽  
2013 ◽  
Vol 59 (11) ◽  
pp. 4440-4450 ◽  
Author(s):  
Andreas Eitzlmayr ◽  
Johannes Khinast ◽  
Gudrun Hörl ◽  
Gerold Koscher ◽  
Gavin Reynolds ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Twin Screw Extruder ◽  
Experimental Characterization ◽  
Melt Extrusion ◽  
Screw Extruder ◽  
Twin Screw ◽  
Hot Melt

Melt granulation using a twin-screw extruder: A case study

2006 ◽  
Vol 326 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Barbara Van Melkebeke ◽  
Brenda Vermeulen ◽  
Chris Vervaet ◽  
Jean Paul Remon
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Melt Granulation

Analysis on Melting Mechanism in the Cross Section of Co-Rotating Twin Screw Extruder

2012 ◽  
Vol 548 ◽  
pp. 571-575
Author(s):  
Chang Liang ◽  
Kui Sheng Wang ◽  
Bing Luo
Keyword(s):  
Viscous Dissipation ◽  
Cross Section ◽  
Liquid Fraction ◽  
Melting Process ◽  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Solid Materials ◽  
Positive Displacement ◽  
Twin Screw ◽  
Hot Melt

In this paper, melting process in a co-rotating twin screw extruder was studied based on two dimensional melting model of flow field cross section. Positive displacement conveying characteristic in the melting section was assumed and melting process of each section was regarded as the result of time evolution. Procedure of melting was analyzed according to experiments and numerical simulations, both indicating that solid materials in the flight zones would melt firstly and carcass wrapped in the middle of melt would be molten finally. Liquid fraction contours showed that flow of hot melt played an important role in the melting process of cross section. Four types of melting mechanisms were summarized, in which viscous dissipation heat was discussed in detail, showing that viscous dissipation contributed about 10%-30% to the total energy needed during melting. Screw speed affected viscous dissipation significantly, while heating flux of barrel had little influence on it.

Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation

2014 ◽  
Vol 463 (1) ◽  
pp. 89-97 ◽  
Author(s):  
David Cheng Thiam Tan ◽  
William Wei Lim Chin ◽  
En Hui Tan ◽  
Shiqi Hong ◽  
Wei Gu ◽  
...  
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Release Rates ◽  
Twin Screw ◽  
Melt Granulation
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