In-line solid state prediction during pharmaceutical hot-melt extrusion in a 12mm twin screw extruder using Raman spectroscopy

Lien Saerens; Dima Ghanam; Cedric Raemdonck; Kjell Francois; Jürgen Manz; Rainer Krüger; Susan Krüger; Chris Vervaet; Jean Paul Remon; Thomas De Beer

doi:10.1016/j.ejpb.2014.03.002

In-line solid state prediction during pharmaceutical hot-melt extrusion in a 12mm twin screw extruder using Raman spectroscopy

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2014.03.002 ◽

2014 ◽

Vol 87 (3) ◽

pp. 606-615 ◽

Cited By ~ 16

Author(s):

Lien Saerens ◽

Dima Ghanam ◽

Cedric Raemdonck ◽

Kjell Francois ◽

Jürgen Manz ◽

...

Keyword(s):

Raman Spectroscopy ◽

Solid State ◽

Hot Melt Extrusion ◽

Twin Screw Extruder ◽

Melt Extrusion ◽

Screw Extruder ◽

State Prediction ◽

Twin Screw ◽

Hot Melt

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Experimental characterization and modeling of twin-screw extruder elements for pharmaceutical hot melt extrusion

AIChE Journal ◽

10.1002/aic.14184 ◽

2013 ◽

Vol 59 (11) ◽

pp. 4440-4450 ◽

Cited By ~ 21

Author(s):

Andreas Eitzlmayr ◽

Johannes Khinast ◽

Gudrun Hörl ◽

Gerold Koscher ◽

Gavin Reynolds ◽

...

Keyword(s):

Hot Melt Extrusion ◽

Twin Screw Extruder ◽

Experimental Characterization ◽

Melt Extrusion ◽

Screw Extruder ◽

Twin Screw ◽

Hot Melt

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Improving the API dissolution rate during pharmaceutical hot-melt extrusion I: Effect of the API particle size, and the co-rotating, twin-screw extruder screw configuration on the API dissolution rate

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2014.11.024 ◽

2015 ◽

Vol 478 (1) ◽

pp. 103-112 ◽

Cited By ~ 28

Author(s):

Meng Li ◽

Costas G. Gogos ◽

Nicolas Ioannidis

Keyword(s):

Particle Size ◽

Dissolution Rate ◽

Hot Melt Extrusion ◽

Twin Screw Extruder ◽

Melt Extrusion ◽

Screw Extruder ◽

Extruder Screw ◽

Twin Screw ◽

Hot Melt

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Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2016.11.065 ◽

2017 ◽

Vol 517 (1-2) ◽

pp. 119-127 ◽

Cited By ~ 19

Author(s):

Jeroen Van Renterghem ◽

Ashish Kumar ◽

Chris Vervaet ◽

Jean Paul Remon ◽

Ingmar Nopens ◽

...

Keyword(s):

Raman Spectroscopy ◽

Solid State ◽

Hot Melt Extrusion ◽

Extrusion Process ◽

Melt Extrusion ◽

State Transformation ◽

Solid State Transformation ◽

Hot Melt

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Raman spectroscopy for the in-line polymer–drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2010.09.015 ◽

2011 ◽

Vol 77 (1) ◽

pp. 158-163 ◽

Cited By ~ 103

Author(s):

L. Saerens ◽

L. Dierickx ◽

B. Lenain ◽

C. Vervaet ◽

J.P. Remon ◽

...

Keyword(s):

Raman Spectroscopy ◽

Solid State ◽

Hot Melt Extrusion ◽

Extrusion Process ◽

Melt Extrusion ◽

Hot Melt ◽

Solid State Characterization

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In-Line Raman Spectroscopy and Multivariate Curve Resolution for Visualization of Process-Induced Solid-State Transformations during Hot Melt Extrusion

10.26226/morressier.57d6b2bcd462b8028d88ddc4 ◽

2016 ◽

Author(s):

Lærke Arnfast

Keyword(s):

Raman Spectroscopy ◽

Solid State ◽

Hot Melt Extrusion ◽

Multivariate Curve Resolution ◽

Melt Extrusion ◽

Curve Resolution ◽

Hot Melt

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Raman Spectroscopy as a Process Analytical Tool for In-line and Real-time Monitoring of a Pharmaceutical Hot-melt Extrusion Process

10.3390/ecps2011-00510 ◽

2011 ◽

Author(s):

Lien Saerens ◽

Thomas De Beer ◽

Jean Paul Remon ◽

Chris Vervaet

Keyword(s):

Raman Spectroscopy ◽

Real Time ◽

Hot Melt Extrusion ◽

Extrusion Process ◽

Analytical Tool ◽

Real Time Monitoring ◽

Melt Extrusion ◽

Hot Melt

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Hot-Melt Granulation in a Twin Screw Extruder: Effects of Processing on Formulations with Caffeine and Ibuprofen

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23739 ◽

2013 ◽

Vol 102 (12) ◽

pp. 4330-4336 ◽

Cited By ~ 16

Author(s):

Sharleen Weatherley ◽

B.O. MU ◽

Michael R. Thompson ◽

Paul J. Sheskey ◽

Kevin P. O'Donnell

Keyword(s):

Twin Screw Extruder ◽

Screw Extruder ◽

Twin Screw ◽

Hot Melt Granulation ◽

Hot Melt ◽

Melt Granulation

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Process design and control of a twin screw hot melt extrusion for continuous pharmaceutical tamper-resistant tablet production

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2015.09.010 ◽

2016 ◽

Vol 87 ◽

pp. 14-21 ◽

Cited By ~ 27

Author(s):

J. Baronsky-Probst ◽

C.-V. Möltgen ◽

W. Kessler ◽

R.W. Kessler

Keyword(s):

Process Design ◽

Hot Melt Extrusion ◽

Melt Extrusion ◽

Twin Screw ◽

And Control ◽

Hot Melt

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Process monitoring and fault detection on a hot-melt extrusion process using in-line Raman spectroscopy and a hybrid soft sensor

Computers & Chemical Engineering ◽

10.1016/j.compchemeng.2019.03.019 ◽

2019 ◽

Vol 125 ◽

pp. 400-414 ◽

Cited By ~ 4

Author(s):

Furqan Tahir ◽

Muhammad T. Islam ◽

John Mack ◽

John Robertson ◽

David Lovett

Keyword(s):

Raman Spectroscopy ◽

Fault Detection ◽

Process Monitoring ◽

Hot Melt Extrusion ◽

Extrusion Process ◽

Soft Sensor ◽

Melt Extrusion ◽

Hot Melt

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Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b00703 ◽

2019 ◽

Vol 16 (10) ◽

pp. 4361-4371 ◽

Cited By ~ 6

Author(s):

Ecaterina Bordos ◽

Muhammad T. Islam ◽

Alastair J. Florence ◽

Gavin W. Halbert ◽

John Robertson

Keyword(s):

Raman Spectroscopy ◽

Active Pharmaceutical Ingredient ◽

Hot Melt Extrusion ◽

Melt Extrusion ◽

Polymeric Matrices ◽

Hot Melt

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