scholarly journals Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

2016 ◽  
Vol 105 (2) ◽  
pp. 838-845 ◽  
Author(s):  
Erica Bäckström ◽  
Anders Lundqvist ◽  
Elin Boger ◽  
Petter Svanberg ◽  
Pär Ewing ◽  
...  
Keyword(s):  
Lung Slice

scholarly journals Bordetella bronchiseptica promotes adherence, colonization, and cytotoxicity of Streptococcus suis in a porcine precision-cut lung slice model

Virulence ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 84-95
Author(s):  
Désirée Vötsch ◽  
Maren Willenborg ◽  
Wolfgang Baumgärtner ◽  
Manfred Rohde ◽  
Peter Valentin-Weigand
Keyword(s):  
Streptococcus Suis ◽  
Bordetella Bronchiseptica ◽  
Lung Slice

scholarly journals Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways

Xenobiotica ◽  
2019 ◽  
Vol 49 (9) ◽  
pp. 1106-1115 ◽  
Author(s):  
Joshua L. Kennedy ◽  
Richard C. Kurten ◽  
Sandra McCullough ◽  
Reynold A. Panettieri ◽  
Cynthia Koziol-White ◽  
...  
Keyword(s):  
Lung Slice

scholarly journals A Co-Culture System with an Organotypic Lung Slice and an Immortal Alveolar Macrophage Cell Line to Quantify Silica-Induced Inflammation

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0117056 ◽  
Author(s):  
Falk Hofmann ◽  
Robert Bläsche ◽  
Michael Kasper ◽  
Kathrin Barth
Keyword(s):  
Alveolar Macrophage ◽  
Cell Line ◽  
Culture System ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Lung Slice

Rhinovirus Infection Induces Th2-Promoting Innate Cytokines in an Ex Vivo Precision Cut Lung Slice Model

2015 ◽  
Vol 135 (2) ◽  
pp. AB145
Author(s):  
Joshua L. Kennedy ◽  
Emily Brown ◽  
Megan Kurten ◽  
Richard Kurten ◽  
Stacie M. Jones
Keyword(s):  
Ex Vivo ◽  
Lung Slice ◽  
Rhinovirus Infection

Effects of hypoxia, hyperoxia and hypercapnia on NEBs studied in a new in situ lung slice model for live cell imaging

2007 ◽  
Vol 135 (1-2) ◽  
pp. 68
Author(s):  
Ian De Proost ◽  
Isabel Pintelon ◽  
Inge Brouns ◽  
Daniela Riccardi ◽  
Paul Kemp ◽  
...  
Keyword(s):  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Lung Slice

scholarly journals Paramyxovirus infections in ex vivo lung slice cultures of different host species

2013 ◽  
Vol 193 (1) ◽  
pp. 159-165 ◽  
Author(s):  
D. Tien Nguyen ◽  
Rory D. de Vries ◽  
Martin Ludlow ◽  
Bernadette G. van den Hoogen ◽  
Ken Lemon ◽  
...  
Keyword(s):  
Host Species ◽  
Ex Vivo ◽  
Lung Slice

Cysteine Esters Protect Cultured Rodent Lung Slices from Sulphur Mustard

1994 ◽  
Vol 13 (11) ◽  
pp. 743-748 ◽  
Author(s):  
Paul E. Wilde ◽  
David G. Upshall
Keyword(s):  
Structural Changes ◽  
Methyl Esters ◽  
Dimethyl Ester ◽  
Rat Lung ◽  
Sulphur Mustard ◽  
Lung Slice ◽  
Pretreatment Time ◽  
Acetyl Cysteine

1 In previous studies an in vitro rat lung slice system was used to investigate the metabolic and structural changes after exposure to known lung toxicants. 2 In this study, the same system was used to identify the ability of cysteine esters to protect against sulphur mustard toxicity. 3 The cyclopentyl (CCPE), cyclohexyl (CCHE), isopropyl (CIPE), methyl (CME) esters of cysteine, cystine dimethyl ester (CDME), cysteine (CySH) and N-acetyl cysteine (NAc) were all non-toxic to cultured rat lung slices at 5 mM (equivalent cysteine concentration) after a pretreatment time of 30 min. 4 Pretreatment with the isopropyl, cyclohexyl, cyclopentyl and methyl esters of cysteine at concentrations higher than 1 mM protected against an IC50 of sulphur mustard, however, neither cysteine nor N-acetylcysteine protected. 5 We propose that the extent of protection is directly related to increased levels of intracellular cysteine provided by the esters of cysteine.

Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities

Toxicology ◽  
2007 ◽  
Vol 231 (1) ◽  
pp. 68-80 ◽  
Author(s):  
Daphnee S. Pushparajah ◽  
Meera Umachandran ◽  
Kathryn E. Plant ◽  
Nick Plant ◽  
Costas Ioannides
Keyword(s):  
Epoxide Hydrolase ◽  
Glutathione S Transferase ◽  
Lung Slice

Neuroepithelial bodies as airway hypoxia sensors: Re-evaluation of the concept in a GAD67-GFP mouse lung slice model

2013 ◽  
Vol 177 (1) ◽  
pp. 33-34
Author(s):  
K. Schnorbusch ◽  
I. Brouns ◽  
R. Lembrechts ◽  
I. Pintelon ◽  
P.J. Kemp ◽  
...  
Keyword(s):  
Mouse Lung ◽  
Neuroepithelial Bodies ◽  
Lung Slice

scholarly journals Airway Contractility in the Precision-Cut Lung Slice after Cryopreservation

2014 ◽  
Vol 50 (5) ◽  
pp. 876-881 ◽  
Author(s):  
Sonia R. Rosner ◽  
Sumati Ram-Mohan ◽  
Jesus R. Paez-Cortez ◽  
Tera L. Lavoie ◽  
Maria L. Dowell ◽  
...  
Keyword(s):  
Lung Slice
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