Structural modifications in metal complexes of a plant metallothionein caused by reductive radical stress: a Raman study

2009 ◽  
Vol 40 (11) ◽  
pp. 1687-1693 ◽  
Author(s):  
Armida Torreggiani ◽  
Jordi Domènech ◽  
Anna Tinti
Keyword(s):  
Metal Complexes ◽  
Structural Modifications ◽  
Plant Metallothionein ◽  
Raman Study

scholarly journals Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

2021 ◽  
Vol 11 (7) ◽  
pp. 3038
Author(s):  
Maria Letizia Di Pietro ◽  
Giuseppina La Ganga ◽  
Francesco Nastasi ◽  
Fausto Puntoriero
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Mechanism Of Action ◽  
Spectroscopic Techniques ◽  
Biological Applications ◽  
Ancillary Ligands ◽  
Structural Modifications ◽  
Over Time

Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

Comparative Raman study of four plant metallothionein isoforms: Insights into their Zn(II) clusters and protein conformations

2016 ◽  
Vol 156 ◽  
pp. 55-63 ◽  
Author(s):  
Mireia Tomas ◽  
Anna Tinti ◽  
Roger Bofill ◽  
Mercè Capdevila ◽  
Silvia Atrian ◽  
...  
Keyword(s):  
Protein Conformations ◽  
Metallothionein Isoforms ◽  
Plant Metallothionein ◽  
Raman Study

SYNTHESIS AND CHARACTERIZATION FOR VARIOUS BIOLOGICAL ACTIVITIES OF TRANSITION METAL COMPLEXES OF QUERCETIN

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 15-22
Author(s):  
M. K Gadhwal ◽  
◽  
S. C Patil ◽  
P Dmello ◽  
U Joshi .
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Biological Activities ◽  
Hydroxyl Groups ◽  
Structural Modifications ◽  
Cu Complex ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory

Flavonoids are a group of polyphenolic compounds with multiple biological activities including antioxidant, anti-inflammatory and anti-cancer activities. The reduced bioavailability of flavonoids, however calls for structural modifications. Quercetin possesses multiple hydroxyl groups and an ability to chelate metal ions. Transition metal complexes have shown therapeutic promises in treatment of both inflammation and cancer. The present work describes synthesis of transition metal complexes of quercetin which resulted in the synthesis of the complexes of the type M2L which were characterized by IR and proton NMR. Although anti-oxidant and anti-inflammatory activity of the quercetin-Cu complex was higher than quercetin, the anticancer activity of the quercetin-Zn complex was much higher. A mechanism of action for the same is proposed.

High water pressure - high temperature autoclave for in situ Raman study of fuel cell/electrolyser materials.

2012 ◽  
Vol 1385 ◽  
Author(s):  
Aneta Slodczyk ◽  
Oumaya Zaafrani ◽  
Philippe Colomban
Keyword(s):  
High Temperature ◽  
Raman Scattering ◽  
Water Pressure ◽  
Water Vapor Pressure ◽  
High Water ◽  
Water Steam ◽  
Proton Conducting ◽  
Structural Modifications ◽  
Raman Study

ABSTRACTAccording to the recent hydrogen and methanol economy, the proton conducting materials appear very interesting as an electrolytic membrane and/or an electrode component of fuel cells, CO2/Syngas converters and water steam electrolysers. Prior to the long lifetime requirements their structural and mechanical behaviors as a function of operating condition: high temperature and high water vapor pressure, have to be well determined. Consequently, we designed the autoclave working till 620°C and 50 bars of H2O pressure equipped with a sapphire window allowing in situ Raman scattering measurements. It should be stressed that Raman scattering is an optical technique very efficient to detect both long and short range order structural modifications. The technical and scientific challenges/difficulties encountered during the studies performed on proton conducting zirconates are discussed.

Structural modifications of intercellular junctions.

1978 ◽  
Vol 36 (2) ◽  
pp. 330-331
Author(s):  
J. Metz ◽  
M. Merlo ◽  
W. G. Forssmann
Keyword(s):  
Gap Junctions ◽  
Intercellular Junctions ◽  
Cell Isolation ◽  
Extrahepatic Cholestasis ◽  
Structural Modifications ◽  
Pancreatic Duct Ligation ◽  
Pancreatic Cells ◽  
Duct Ligation ◽  
Thin Sectioning ◽  
And Function

Structure and function of intercellular junctions were studied under the electronmicroscope using conventional thin sectioning and freeze-etch replicas. Alterations of tight and gap junctions were analyzed 1. of exocrine pancreatic cells under cell isolation conditions and pancreatic duct ligation and 2. of hepatocytes during extrahepatic cholestasis.During the different steps of cell isolation of exocrine pancreatic cells, gradual changes of tight and gap junctions were observed. Tight junctions, which formed belt-like structures around the apex of control acinar cells in situ, subsequently diminished, became interrupted and were concentrated into macular areas (Fig. 1). Aggregations of membrane associated particles, which looked similar to gap junctions, were intermixed within tight junctional areas (Fig. 1). These structures continously disappeared in the last stages of the isolation procedure. The intercellular junctions were finally separated without destroying the integrity of the cell membrane, which was confirmed with porcion yellow, lanthanum chloride and horse radish peroxidase.

Mechanochemical changes on cyclometalated Ir(iii) acyclic carbene complexes – design and tuning of luminescent mechanochromic transition metal complexes

2020 ◽  
Vol 7 (3) ◽  
pp. 786-794 ◽  
Author(s):  
Jingqi Han ◽  
Kin-Man Tang ◽  
Shun-Cheung Cheng ◽  
Chi-On Ng ◽  
Yuen-Kiu Chun ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Carbene Complexes ◽  
New Class

A new class of luminescent cyclometalated Ir(iii) complexes with readily tunable mechanochromic properties derived from the mechanically induced trans-to-cis isomerization have been developed.

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