scholarly journals Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

2021 ◽  
Vol 11 (7) ◽  
pp. 3038
Author(s):  
Maria Letizia Di Pietro ◽  
Giuseppina La Ganga ◽  
Francesco Nastasi ◽  
Fausto Puntoriero
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Mechanism Of Action ◽  
Spectroscopic Techniques ◽  
Biological Applications ◽  
Ancillary Ligands ◽  
Structural Modifications ◽  
Over Time

Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

2021 ◽  
Author(s):  
Guang-Xi Xu ◽  
Eunice Chiu-Lam Mak ◽  
Kenneth Kam-Wing Lo
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Critical Review ◽  
Biological Applications ◽  
Cellular Probes

By virtue of their rich photophysical and photochemical properties, transition metal complexes (TMCs) have been extensively studied in multidisciplinary research. In this review, recent studies on TMCs for biological applications...

Ultrafast Photochemistry of a Molybdenum Carbonyl-Nitrosyl Complex with a Triazacyclononane Coligand

2021 ◽  
Author(s):  
Niklas Gessner ◽  
Anna Karina Bäck ◽  
Johannes Knorr ◽  
Christoph Nagel ◽  
Philipp Marquetand ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Nitrosyl Complex ◽  
Molybdenum Carbonyl

Transition metal complexes capable of releasing small molecules such as carbon monoxide and nitric oxide upon photoactivation are versatile tools in various fields of chemistry and biology. In this work,...

scholarly journals Transition metal complexes of 5-bromosalicylidene-4-amino-3-mercapto-1,2,4-triazine-5-one: Synthesis, characterization, catalytic and antibacterial studies

2011 ◽  
Vol 76 (1) ◽  
pp. 75-83 ◽  
Author(s):  
A.S. Ramasubramanian ◽  
Ramachandra Bhat ◽  
Ramakrishna Dileep ◽  
Sandya Rani
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Pathogenic Bacteria ◽  
Magnetic Moments ◽  
Spectroscopic Techniques ◽  
Antibacterial Studies ◽  
Metal Precursors ◽  
Square Planar ◽  
Bactericidal Properties

Transition metal complexes of 5-bromosalicylidene-4-amino-3- mercapto-1,2,4-triazine-5-one with metal precursors, such as Cu(II), Ni(II), Co(II) and Pd(II), were synthesized and characterized by physicochemical and spectroscopic techniques. All the complexes are of the ML type. Based on analytical, spectral data and magnetic moments, the Co(II) and Ni(II) complexes were assigned octahedral geometries, while the Cu (II) and Pd(II) complexes square planar. A study on the catalytic oxidation of benzyl alcohol, cyclohexanol, cinnamyl alcohol, 2-propanol and 2- methyl-1-propanol was performed with N-methylmorpholine-N-oxide (NMO) and molecular oxygen as co-oxidants. All the complexes and their parent organic moiety were screened for their biological activity on several pathogenic bacteria and were found to possess appreciable bactericidal properties.

Metal complex interactions with DNA

2015 ◽  
Vol 44 (8) ◽  
pp. 3505-3526 ◽  
Author(s):  
Benjamin J. Pages ◽  
Dale L. Ang ◽  
Elisé P. Wright ◽  
Janice R. Aldrich-Wright
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Spectroscopic Techniques ◽  
Binding Modes ◽  
Dna Interactions ◽  
Diverse Range ◽  
Dna Structures ◽  
Complex Interactions

Increasing numbers of DNA structures are being revealed using a diverse range of transition metal complexes and biophysical spectroscopic techniques. Here we present a review of metal complex-DNA interactions in which several binding modes and DNA structural forms are explored.

scholarly journals Preparation, Spectroscopic Characterization and Theoretical Studies of Transition Metal Complexes with 1-[(2-(1H-indol-3-yl)ethylimino)methyl]naphthalene-2-ol Ligand

2019 ◽  
Vol 31 (11) ◽  
pp. 2430-2438 ◽  
Author(s):  
Vian Yamin Jirjees ◽  
Veyan Taher Suleman ◽  
Abbas Ali Salih Al-Hamdani ◽  
Suzan Duraid Ahmed
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Spectroscopic Characterization ◽  
Bidentate Ligand ◽  
Spectroscopic Techniques ◽  
Theoretical Studies ◽  
Ft Ir ◽  
Uv Visible ◽  
Methyl Naphthalene

A new Schiff base [1-((2-(1H-indol-3-yl)ethylimino)methyl)naphthalene-2-ol] (HL) has been synthesized by condensing (2-hydroxy-1-naphthaldehyde) with (2-(1H-indol-3-yl)ethylamine). In turn, its transition metal complexes were prepared having the general formula; [Pt(IV)Cl2(L)2], [Re(V)Cl2(L)2]Cl and [Pd(L)2], 2K[M(II)Cl2(L)2] where M(II) = Co, Ni, Cu] are reported. Ligand as well as metal complexes are characterized by spectroscopic techniques such as FT-IR, UV-visible, 13C & 1H NMR, mass, elemental analysis. The results suggested that the ligand behaves like a bidentate ligand for all the synthesized complexes. On the other hand, theoretical studies of the ligand as well its metal complexes were conducted at gas phase using HyperChem 8.0. These metal complexes exhibited good antibacterial activity.

scholarly journals Low-coordinate first-row transition metal complexes in catalysis and small molecule activation

2019 ◽  
Vol 48 (33) ◽  
pp. 12365-12381 ◽  
Author(s):  
Laurence J. Taylor ◽  
Deborah L. Kays
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Small Molecule ◽  
High Reactivity ◽  
Small Molecule Activation ◽  
Coordination Numbers

In this Perspective, we will highlight selected examples of transition metal complexes with low coordination numbers whose high reactivity has been exploited in catalysis and the activation of small molecules featuring strong bonds (N2, CO2, and CO).

scholarly journals Preparation, spectral characterization and biological applications of Schiff base ligand and its transition metal complexes

2019 ◽  
Vol 1 ◽  
pp. 100012
Author(s):  
H.M. Vinusha ◽  
Shiva Prasad Kollur ◽  
H.D. Revanasiddappa ◽  
Ramith Ramu ◽  
Prithvi S. Shirahatti ◽  
...  
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Spectral Characterization ◽  
Biological Applications

Synthesis, structural characterization, and reactivity of late transition-metal complexes bearing linked cyclopentadienyl–carboranyl ligands

2012 ◽  
Vol 90 (1) ◽  
pp. 108-117 ◽  
Author(s):  
Dongmei Liu ◽  
Zaozao Qiu ◽  
Hoi-Shan Chan ◽  
Zuowei Xie
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Structural Characterization ◽  
Molecular Structures ◽  
Spectroscopic Techniques ◽  
Late Transition Metal ◽  
X Ray ◽  
Elemental Analyses ◽  
Late Transition

Late transition-metal complexes bearing linked cyclopentadienyl/indenyl–carboranyl ligands were synthesized and their reactivities were examined. Reaction of Li2[Me2C(L)(C2B10H10)] (L = C5H4, C9H6, Me2NCH2CH2C5H3) with MCl2(PPh3)2 in Et2O afforded [η5:σ-Me2C(C5H4)(C2B10H10)]M(PPh3) (M = Co (4), Ni (5)), [η5:σ-Me2C(C9H6)(C2B10H10)]M(PPh3) (M = Co (6), Ni (7)), and [η5:σ-Me2C(Me2NCH2CH2C5H3)(C2B10H10)]Ni(PPh3) (8). Treatment of 4 or 5 with 2,6-dimethylphenylisocyanide, N-heterocyclic carbene (NHC), PCy3, or 1,2-bis(diphenylphosphino)ethane (dppe) gave the corresponding PPh3 displacement complexes [η5:σ-Me2C(C5H4)(C2B10H10)]M(2,6-Me2C6H3NC) (M = Co (9), Ni (10)), [η5:σ-Me2C(C5H4)(C2B10H10)]M[1,3-(2,6-i-Pr2C6H3)2C3N2H2] (M = Co (11), Ni (12)), [η5:σ-Me2C(C5H4)(C2B10H10)]Ni(PCy3) (13), or {[η5:σ-Me2C(C5H4)(C2B10H10)]Co}2(dppe) (14), respectively. These complexes were characterized by various spectroscopic techniques and elemental analyses. The molecular structures of 4–14 were further confirmed by single-crystal X-ray analyses.

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