Are predictive factors for locoregional recurrence in skin‐sparing and nipple‐sparing mastectomies time‐dependent?

2021 ◽  
Author(s):  
Kadri Altundag
Keyword(s):  
Predictive Factors ◽  
Locoregional Recurrence ◽  
Time Dependent ◽  
Nipple Sparing

scholarly journals Improved risk estimation of locoregional recurrence, secondary contralateral tumors and distant metastases in early breast cancer: the INFLUENCE 2.0 model

2021 ◽  
Author(s):  
Vinzenz Völkel ◽  
Tom A. Hueting ◽  
Teresa Draeger ◽  
Marissa C. van Maaren ◽  
Linda de Munck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Locoregional Recurrence ◽  
Clinical Decision Making ◽  
Metastatic Breast ◽  
Distant Metastases ◽  
Time Dependent ◽  
Individual Risk ◽  
Primary Tumors ◽  
Statistical Approaches

Abstract Purpose To extend the functionality of the existing INFLUENCE nomogram for locoregional recurrence (LRR) of breast cancer toward the prediction of secondary primary tumors (SP) and distant metastases (DM) using updated follow-up data and the best suitable statistical approaches. Methods Data on women diagnosed with non-metastatic invasive breast cancer were derived from the Netherlands Cancer Registry (n = 13,494). To provide flexible time-dependent individual risk predictions for LRR, SP, and DM, three statistical approaches were assessed; a Cox proportional hazard approach (COX), a parametric spline approach (PAR), and a random survival forest (RSF). These approaches were evaluated on their discrimination using the Area Under the Curve (AUC) statistic and on calibration using the Integrated Calibration Index (ICI). To correct for optimism, the performance measures were assessed by drawing 200 bootstrap samples. Results Age, tumor grade, pT, pN, multifocality, type of surgery, hormonal receptor status, HER2-status, and adjuvant therapy were included as predictors. While all three approaches showed adequate calibration, the RSF approach offers the best optimism-corrected 5-year AUC for LRR (0.75, 95%CI: 0.74–0.76) and SP (0.67, 95%CI: 0.65–0.68). For the prediction of DM, all three approaches showed equivalent discrimination (5-year AUC: 0.77–0.78), while COX seems to have an advantage concerning calibration (ICI < 0.01). Finally, an online calculator of INFLUENCE 2.0 was created. Conclusions INFLUENCE 2.0 is a flexible model to predict time-dependent individual risks of LRR, SP and DM at a 5-year scale; it can support clinical decision-making regarding personalized follow-up strategies for curatively treated non-metastatic breast cancer patients.

Abstract P6-09-03: Time-dependent nomogram for risk of locoregional recurrence in early breast cancer patients: 10 year extension

2016 ◽  
Author(s):  
A Witteveen ◽  
IMH Vliegen ◽  
GS Sonke ◽  
JM Klaase ◽  
MJ IJzerman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Locoregional Recurrence ◽  
Time Dependent ◽  
Breast Cancer Patients

Risk of Locoregional Recurrence in Patients With False-Negative Frozen Section or Close Margins of Retroareolar Specimen in Nipple-Sparing Mastectomy

2012 ◽  
Vol 19 (13) ◽  
pp. 4117-4123 ◽  
Author(s):  
Maximiliano Cassilha Kneubil ◽  
Visnu Lohsiriwat ◽  
Giuseppe Curigliano ◽  
Janaina Brollo ◽  
Edoardo Botteri ◽  
...  
Keyword(s):  
Locoregional Recurrence ◽  
Frozen Section ◽  
False Negative ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

scholarly journals Personalisation of breast cancer follow-up: a time-dependent prognostic nomogram for the estimation of annual risk of locoregional recurrence in early breast cancer patients

2015 ◽  
Vol 152 (3) ◽  
pp. 627-636 ◽  
Author(s):  
Annemieke Witteveen ◽  
Ingrid M. H. Vliegen ◽  
Gabe S. Sonke ◽  
Joost M. Klaase ◽  
Maarten J. IJzerman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Locoregional Recurrence ◽  
Time Dependent ◽  
Breast Cancer Patients ◽  
Annual Risk

Mortality in incident haemodialysis patients: time-dependent haemoglobin levels and erythropoiesis-stimulating agent dose are independent predictive factors in the ANSWER study

2010 ◽  
Vol 25 (8) ◽  
pp. 2702-2710 ◽  
Author(s):  
J. Fort ◽  
X. Cuevas ◽  
F. Garcia ◽  
R. Perez-Garcia ◽  
F. Llados ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Time Dependent

scholarly journals Predictive factors in patients with hepatocellular carcinoma receiving sorafenib therapy using time-dependent receiver operating characteristic analysis

2017 ◽  
Vol 8 (3) ◽  
pp. 378-387 ◽  
Author(s):  
Hiroki Nishikawa ◽  
Norihiro Nishijima ◽  
Hirayuki Enomoto ◽  
Azusa Sakamoto ◽  
Akihiro Nasu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Receiver Operating Characteristic ◽  
Predictive Factors ◽  
Operating Characteristic ◽  
Receiver Operating Characteristic Analysis ◽  
Time Dependent ◽  
Characteristic Analysis ◽  
Sorafenib Therapy ◽  
Receiver Operating

scholarly journals Direct-to-implant breast reconstruction following nipple-sparing mastectomy: predictive factors of adverse surgical outcomes in Asian patients

2021 ◽  
Vol 48 (5) ◽  
pp. 483-493
Author(s):  
Chun-Lin Su ◽  
Jia-Ruei Yang ◽  
Wen-Ling Kuo ◽  
Shin-Cheh Chen ◽  
David Chon-Fok Cheong ◽  
...  
Keyword(s):  
Breast Reconstruction ◽  
Predictive Factors ◽  
Tissue Expander ◽  
Intraoperative Radiotherapy ◽  
Dermal Matrix ◽  
Asian Patients ◽  
Areolar Complex ◽  
Acute Complications ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Background Direct-to-implant (DTI) breast reconstruction after nipple-sparing mastectomy (NSM) with the use of acellular dermal matrix (ADM) provides reliable outcomes; however, the use of ADM is associated with a higher risk of complications. We analyzed our experiences of post-NSM DTI without ADM and identified the predictive factors of adverse surgical outcomes.Methods Patients who underwent NSM and immediate DTI or two-stage tissue expander (TE) breast reconstruction from 2009 to 2020 were enrolled. Predictors of adverse endpoints were analyzed.Results There were 100 DTI and 29 TE reconstructions. The TE group had a higher rate of postmastectomy radiotherapy (31% vs. 11%; P=0.009), larger specimens (317.37±176.42 g vs. 272.08±126.33 g; P=0.047), larger implants (360.84±85.19 g vs. 298.83±81.13 g; P=0.004) and a higher implant/TE exposure ratio (10.3% vs. 1%; P=0.035). In DTI reconstruction, age over 50 years (odds ratio [OR], 5.43; 95% confidence interval [CI], 1.50–19.74; P=0.010) and a larger mastectomy weight (OR, 1.65; 95% CI, 1.08–2.51; P=0.021) were associated with a higher risk of acute complications. Intraoperative radiotherapy for the nipple-areolar complex increased the risk of acute complications (OR, 4.05; 95% CI, 1.07–15.27; P=0.039) and the likelihood of revision surgery (OR, 5.57; 95% CI, 1.25–24.93; P=0.025).Conclusions Immediate DTI breast reconstruction following NSM is feasible in Asian patients with smaller breasts.

scholarly journals Predictive Factors and Pattern of Locoregional Recurrence After Prophylactic Central Neck Dissection in Papillary Thyroid Carcinoma

2014 ◽  
Vol 21 (13) ◽  
pp. 4181-4187 ◽  
Author(s):  
Brian Hung-Hin Lang ◽  
Diane T. Y. Chan ◽  
Kai Pun Wong ◽  
Kandy K. C. Wong ◽  
Koon Yat Wan
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Neck Dissection ◽  
Predictive Factors ◽  
Locoregional Recurrence ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Prophylactic Central Neck Dissection
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