Chiral separation of lenalidomide by liquid chromatography on polysaccharide-type stationary phases and by capillary electrophoresis using cyclodextrin selectors

2018 ◽  
Vol 41 (6) ◽  
pp. 1414-1423 ◽  
Author(s):  
Zoltán-István Szabó ◽  
Mohammadhassan Foroughbakhshfasaei ◽  
Réka Gál ◽  
Péter Horváth ◽  
Balázs Komjáti ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Chiral Separation ◽  
Stationary Phases

Chiral separation of oxazolidinone analogues by liquid chromatography on polysaccharide stationary phases using polar organic mode

2021 ◽  
pp. 462741
Author(s):  
Máté Dobó ◽  
Mohammadhassan Foroughbakhshfasaei ◽  
Péter Horváth ◽  
Zoltán-István Szabó ◽  
Gergő Tóth
Keyword(s):  
Liquid Chromatography ◽  
Chiral Separation ◽  
Stationary Phases

Recent Trends in Chiral Separation-A Collective Paradigm of Selected Chiral Impurities

2020 ◽  
Vol 16 (5) ◽  
pp. 456-473
Author(s):  
Prachi Raikar ◽  
Gurupadayya Bannimath
Keyword(s):  
Gas Chromatography ◽  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Adverse Effects ◽  
Chiral Separation ◽  
Pharmaceutical Analysis ◽  
High Performance ◽  
Ich Guidelines ◽  
Recent Trends

Chiral separation plays a very important role in the modern pharmaceutical analysis and will continue in upcoming years. Separation and identification of chiral impurities are indispensable. According to ICH guidelines, only the active enantiomer of the drug has to be marketed, so there is a focus on separation of the inactive enantiomer which acts as a chiral impurity. The impurities present in the enantiomers also pose various toxic adverse effects on bioavailability and efficacy, hence the need to separate these impurities will forever be trending. This review primarily focuses on the separation techniques like Capillary Electrophoresis (CE), High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Supercritical Fluid Chromatography (SFC) followed by the year-wise trend in the separation of selected chiral impurities. In the coming years, researchers should work on using ultra-fast, selective, and sensitive methods for the effective separation of chiral impurities.

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