Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

2017 ◽  
Vol 40 (14) ◽  
pp. 2863-2882 ◽  
Author(s):  
Imran Ali ◽  
Mohd. Suhail ◽  
Leonid Asnin
2018 ◽  
Vol 41 (6) ◽  
pp. 1414-1423 ◽  
Author(s):  
Zoltán-István Szabó ◽  
Mohammadhassan Foroughbakhshfasaei ◽  
Réka Gál ◽  
Péter Horváth ◽  
Balázs Komjáti ◽  
...  

2020 ◽  
Vol 16 (5) ◽  
pp. 456-473
Author(s):  
Prachi Raikar ◽  
Gurupadayya Bannimath

Chiral separation plays a very important role in the modern pharmaceutical analysis and will continue in upcoming years. Separation and identification of chiral impurities are indispensable. According to ICH guidelines, only the active enantiomer of the drug has to be marketed, so there is a focus on separation of the inactive enantiomer which acts as a chiral impurity. The impurities present in the enantiomers also pose various toxic adverse effects on bioavailability and efficacy, hence the need to separate these impurities will forever be trending. This review primarily focuses on the separation techniques like Capillary Electrophoresis (CE), High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Supercritical Fluid Chromatography (SFC) followed by the year-wise trend in the separation of selected chiral impurities. In the coming years, researchers should work on using ultra-fast, selective, and sensitive methods for the effective separation of chiral impurities.


2004 ◽  
Vol 25 (16) ◽  
pp. 2711-2719 ◽  
Author(s):  
Yu-Ping Zhang ◽  
Kwang-Pill Lee ◽  
Sang-Ho Kim ◽  
Seong-Ho Choi ◽  
Anantha I. Gopalan ◽  
...  

2014 ◽  
Vol 6 (3) ◽  
pp. 825-830 ◽  
Author(s):  
Samia M. El-Gizawy ◽  
Osama H. Abdelmageed ◽  
Sayed M. Derayea ◽  
Mahmoud A. Omar ◽  
Ahmed M. Abdel-Megied

Two separation methods were developed for the determination of S- and R-perindopril tert-butylamine (erbumine salt) (PER): high performance liquid chromatography (HPLC) and capillary electrophoresis (CE).


2020 ◽  
Vol 16 ◽  
Author(s):  
Kirubanandam Grace Pavithra ◽  
Vasudevan Jaikumar ◽  
Ponnusamy Senthil Kumar ◽  
PanneerSelvam SundarRajan

Background: Many antibiotics were widely used as medication based on their distinctive features. Among them, sulphonamides were commonly used, however their recalcitrant nature makes them difficult to dispose. Hence, their interaction with environment and analytic technique requires considerable attention globally. Objective: Therefore, this review aimed to provide detailed discussion about environmental as well as human health behaviour and analytic techniques corresponding to sulphonamides. Methods: Various results and discussion were extracted from technical journals and books published by different researchers from all over the world. The cited bibliographic references were intentionally investigated in order to extract relevant information related to proposed work. Results: In this review, the determination techniques such as UV-spectroscopy, Enthalpimetry, Immunosensor, Chromatography, Chemiluminescence, Photoinduced fluorometric determination, Capillary electrophoresis for sulphonamide determination were discussed in detail. Among them, High performance liquid chromatography (HPLC) and UV-spectroscopy was effective and extensively used for screening sulphonamide. Conclusion: Knowing the quantification and behaviour of sulphonamide in aqueous solution is mandatory to opt the suitable wastewater treatment required. Hence, choosing appropriate high precision and feasible screening techniques is necessary, which can be attained with this review.


Heliyon ◽  
2021 ◽  
pp. e07707
Author(s):  
Suci Amalia ◽  
Stevin Carolius Angga ◽  
Elvina Dhiaul Iftitah ◽  
Dias Septiana ◽  
Baiq Octaviana D. Anggraeny ◽  
...  

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1135 ◽  
Author(s):  
Raymond B. Yu ◽  
Joselito P. Quirino

Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.


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