Systematic approach to the treatment of enantiomeric separations in capillary electrophoresis and liquid chromatography III. A binding constant-retention factor relationship and effects of acetonitrile on the chiral separation of tioconazole

1996 ◽  
Vol 745 (1-2) ◽  
pp. 25-35 ◽  
Author(s):  
Paul D. Ferguson ◽  
David M. Goodall ◽  
John S. Loran
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Chiral Separation ◽  
Binding Constant ◽  
Systematic Approach ◽  
Retention Factor ◽  
Enantiomeric Separations

Systematic approach to treatment of enantiomeric separations in capillary electrophoresis and liquid chromatography.

1994 ◽  
Vol 680 (1) ◽  
pp. 147-155 ◽  
Author(s):  
Sharron G. Penn ◽  
Gaoyuan Liu ◽  
Edmund T. Bergström ◽  
David M. Goodall ◽  
John S. Loran
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Systematic Approach ◽  
Enantiomeric Separations

Chiral separation of lenalidomide by liquid chromatography on polysaccharide-type stationary phases and by capillary electrophoresis using cyclodextrin selectors

2018 ◽  
Vol 41 (6) ◽  
pp. 1414-1423 ◽  
Author(s):  
Zoltán-István Szabó ◽  
Mohammadhassan Foroughbakhshfasaei ◽  
Réka Gál ◽  
Péter Horváth ◽  
Balázs Komjáti ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Chiral Separation ◽  
Stationary Phases

Recent Trends in Chiral Separation-A Collective Paradigm of Selected Chiral Impurities

2020 ◽  
Vol 16 (5) ◽  
pp. 456-473
Author(s):  
Prachi Raikar ◽  
Gurupadayya Bannimath
Keyword(s):  
Gas Chromatography ◽  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Adverse Effects ◽  
Chiral Separation ◽  
Pharmaceutical Analysis ◽  
High Performance ◽  
Ich Guidelines ◽  
Recent Trends

Chiral separation plays a very important role in the modern pharmaceutical analysis and will continue in upcoming years. Separation and identification of chiral impurities are indispensable. According to ICH guidelines, only the active enantiomer of the drug has to be marketed, so there is a focus on separation of the inactive enantiomer which acts as a chiral impurity. The impurities present in the enantiomers also pose various toxic adverse effects on bioavailability and efficacy, hence the need to separate these impurities will forever be trending. This review primarily focuses on the separation techniques like Capillary Electrophoresis (CE), High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Supercritical Fluid Chromatography (SFC) followed by the year-wise trend in the separation of selected chiral impurities. In the coming years, researchers should work on using ultra-fast, selective, and sensitive methods for the effective separation of chiral impurities.

Comparative study on the chiral separation of phenyl alcohols by capillary electrophoresis and liquid chromatography

2004 ◽  
Vol 25 (16) ◽  
pp. 2711-2719 ◽  
Author(s):  
Yu-Ping Zhang ◽  
Kwang-Pill Lee ◽  
Sang-Ho Kim ◽  
Seong-Ho Choi ◽  
Anantha I. Gopalan ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Comparative Study ◽  
Chiral Separation

Chiral separation of perindopril erbumine enantiomers using high performance liquid chromatography and capillary electrophoresis

2014 ◽  
Vol 6 (3) ◽  
pp. 825-830 ◽  
Author(s):  
Samia M. El-Gizawy ◽  
Osama H. Abdelmageed ◽  
Sayed M. Derayea ◽  
Mahmoud A. Omar ◽  
Ahmed M. Abdel-Megied
Keyword(s):  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Chiral Separation ◽  
High Performance ◽  
Perindopril Erbumine

Two separation methods were developed for the determination of S- and R-perindopril tert-butylamine (erbumine salt) (PER): high performance liquid chromatography (HPLC) and capillary electrophoresis (CE).

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