Treatment of port wine stains with photodynamic therapy, using pulsed dye laser as a Light Source, Compared With Pulsed dye laser alone: A pilot study

2005 ◽  
Vol 36 (4) ◽  
pp. 266-269 ◽  
Author(s):  
Alun V. Evans ◽  
Alistair Robson ◽  
Richard J. Barlow ◽  
Habib A. Kurwa
Author(s):  
Li-Chao Zhang ◽  
Jun Yang ◽  
Yuan-Bo Huang ◽  
Ming-Ye Bi

Background: Port-wine stains occur in 0.3–0.5% newborns, mainly on the face and neck. Pulsed dye laser is recognized as the gold standard treatment; nevertheless, it is associated with a low cure rate and a high recurrence rate. Aims: This study aims to evaluate the efficacy of hemoporfin photodynamic therapy for pulsed dye laser-resistant port-wine stains in children. Methods: We studied 107 children who received hemoporfin photodynamic therapy for port-wine stains on the face and neck that were resistant to pulsed dye laser. After intravenous injection of 5 mg/kg hemoporfin, the local lesion was irradiated with 532 nm LED green light for 20 min with a power density of 80–100 mW/cm2. A total of 65 patients were given a second treatment after eight weeks. The efficacy and therapeutic responses were recorded at four days and eight weeks after each treatment. Results: The efficacy was positively correlated with the number of treatments received; two treatment sessions yielded significantly better results compared to a single treatment with a response rate of 96.9%, a significant response rate of 50.8% and a cure rate of 21.5%, respectively (P < 0.001). After two treatment sessions, the efficacy was negatively correlated with age (P = 0.04). The efficacy for port-wine stains located on the lateral part was better than that of the central face (P = 0.04). The efficacy for the pink type was better than that for the red and purple types (P = 0.03). No allergic or systematic adverse reactions were reported. Limitations: No objective measurement data were available. Conclusion: Hemoporfin photodynamic therapy is effective and safe for pulsed dye laser-resistant facial port-wine stains in children.


2007 ◽  
Vol 32 (6) ◽  
pp. 646-649 ◽  
Author(s):  
H. Liu ◽  
Y. Dang ◽  
X. Chai ◽  
Z. Wang ◽  
L. Ma ◽  
...  

2020 ◽  
Vol 47 (4) ◽  
pp. 348-355 ◽  
Author(s):  
Yue Han ◽  
Hanru Ying ◽  
Xiaolin Zhang ◽  
Wenxin Yu ◽  
Qingqing Cen ◽  
...  

2009 ◽  
Vol 25 (4) ◽  
pp. 525-529 ◽  
Author(s):  
Gerd Kautz ◽  
Ingrid Kautz ◽  
Jenny Segal ◽  
Sabrina Zehren

2020 ◽  
Vol 35 (8) ◽  
pp. 1811-1819
Author(s):  
Dong Li ◽  
Bin Chen ◽  
Hao Zhang ◽  
Yuan Yuan ◽  
Wenxin Fan ◽  
...  

2017 ◽  
Vol 76 (2) ◽  
pp. 321-326 ◽  
Author(s):  
Yoon-Soo Cindy Bae ◽  
Hamad Alabdulrazzaq ◽  
Jeremy A. Brauer ◽  
Roy G. Geronemus

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