scholarly journals Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor

2021 ◽  
Author(s):  
Yueh‐Chi Wu ◽  
Elan D. Louis ◽  
John Gionco ◽  
Ming‐Kai Pan ◽  
Phyllis L. Faust ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Climbing Fiber ◽  
Cerebellar Hemisphere ◽  
Purkinje Cell Dendrites

scholarly journals Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites

Neuron ◽  
2014 ◽  
Vol 84 (1) ◽  
pp. 137-151 ◽  
Author(s):  
Yo Otsu ◽  
Païkan Marcaggi ◽  
Anne Feltz ◽  
Philippe Isope ◽  
Mihaly Kollo ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Calcium Spikes ◽  
K Channels ◽  
Type K ◽  
Activity Dependent ◽  
Purkinje Cell Dendrites

scholarly journals Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Farzaneh Najafi ◽  
Andrea Giovannucci ◽  
Samuel S-H Wang ◽  
Javier F Medina
Keyword(s):  
Purkinje Cell ◽  
Purkinje Cells ◽  
Eyeblink Conditioning ◽  
Climbing Fiber ◽  
Stimulus Strength ◽  
Calcium Signals ◽  
Calcium Spikes ◽  
Conditioning Information ◽  
Teaching Signal ◽  
Purkinje Cell Dendrites

The climbing fiber input to Purkinje cells acts as a teaching signal by triggering a massive influx of dendritic calcium that marks the occurrence of instructive stimuli during cerebellar learning. Here, we challenge the view that these calcium spikes are all-or-none and only signal whether the instructive stimulus has occurred, without providing parametric information about its features. We imaged ensembles of Purkinje cell dendrites in awake mice and measured their calcium responses to periocular airpuffs that serve as instructive stimuli during cerebellar-dependent eyeblink conditioning. Information about airpuff duration and pressure was encoded probabilistically across repeated trials, and in two additional signals in single trials: the synchrony of calcium spikes in the Purkinje cell population, and the amplitude of the calcium spikes, which was modulated by a non-climbing fiber pathway. These results indicate that calcium-based teaching signals in Purkinje cells contain analog information that encodes the strength of instructive stimuli trial-by-trial.

scholarly journals Long-term depression of climbing fiber-evoked calcium transients in Purkinje cell dendrites

2003 ◽  
Vol 100 (5) ◽  
pp. 2878-2883 ◽  
Author(s):  
J. T. Weber ◽  
C. I. De Zeeuw ◽  
D. J. Linden ◽  
C. Hansel
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Calcium Transients ◽  
Long Term Depression ◽  
Purkinje Cell Dendrites

scholarly journals Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes

2018 ◽  
Vol 51 ◽  
pp. 24-29 ◽  
Author(s):  
Danielle Lee ◽  
Shi-Rui Gan ◽  
Phyllis L. Faust ◽  
Elan D. Louis ◽  
Sheng-Han Kuo
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Climbing Fiber ◽  
Synaptic Pathology

scholarly journals Conversion of graded presynaptic climbing fiber activity into graded postsynaptic Ca2+ signals by Purkinje cell dendrites

2018 ◽  
Author(s):  
Michael A. Gaffield ◽  
Jason M. Christie
Keyword(s):  
Purkinje Cell ◽  
Inferior Olive ◽  
Mossy Fiber ◽  
Climbing Fiber ◽  
Climbing Fibers ◽  
Dependent Manner ◽  
Related Information ◽  
External Stimuli ◽  
Purkinje Cell Dendrites

AbstractThe brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the presynaptic activity of their axonal projections in the cerebellar cortex. Further, individual climbing fibers were broadly responsive to different sensory modalities but relayed sensory-related information to the cortex in a lobule-dependent manner. Purkinje cell dendrites faithfully transformed this climbing fiber activity into dendrite-wide Ca2+ signals without a direct contribution from the mossy fiber pathway. These results demonstrate that the size of climbing fiber-evoked Ca2+ signals in Purkinje cell dendrites is largely determined by the firing level of climbing fibers. This coding scheme emphasizes the overwhelming role of the inferior olive in generating salient signals useful for instructing plasticity and learning.

scholarly journals Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites

Neuron ◽  
2019 ◽  
Vol 102 (4) ◽  
pp. 762-769.e4 ◽  
Author(s):  
Michael A. Gaffield ◽  
Audrey Bonnan ◽  
Jason M. Christie
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Purkinje Cell Dendrites

Reply: Purkinje cell loss in essential tremor

2014 ◽  
Vol 29 (10) ◽  
pp. 1330-1331 ◽  
Author(s):  
Holly A. Shill ◽  
Charles H. Adler ◽  
Joseph G. Hentz
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Cell Loss ◽  
Purkinje Cell Loss

Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses

Neuroscience ◽  
2009 ◽  
Vol 162 (3) ◽  
pp. 612-623 ◽  
Author(s):  
L.W.J. Bosman ◽  
A. Konnerth
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Dependent Plasticity ◽  
Activity Dependent
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