Phosphorus nuclear magnetic resonance spectroscopy: In vivo magnesium measurements in the skeletal muscle of normal subjects

2005 ◽  
Vol 36 (3) ◽  
pp. 475-480 ◽  
Author(s):  
Kathleen M. Ward ◽  
Sunder S. Rajan ◽  
Melissa Wysong ◽  
David Radulovic ◽  
Daniel J. Clauw
Keyword(s):  
Skeletal Muscle ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Normal Subjects ◽  
Resonance Spectroscopy ◽  
Nuclear Magnetic

Hypophosphataemic Osteomalacia and Myopathy: Studies with Nuclear Magnetic Resonance Spectroscopy

1984 ◽  
Vol 67 (5) ◽  
pp. 505-509 ◽  
Author(s):  
R. Smith ◽  
R. J. Newman ◽  
G. K. Radda ◽  
M. Stokes ◽  
A. Young
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Normal Subjects ◽  
Resonance Spectroscopy ◽  
Vitamin D Resistant Rickets ◽  
The Right ◽  
Nuclear Magnetic

1. A patient with familial adult-onset hypophosphataemia, whose myopathy was closely related to the plasma phosphate concentration, was investigated by phosphorus nuclear magnetic resonance spectroscopy (31P n.m.r.) in vivo of the right flexor digitorum superficialis muscle. 2. During hypophosphataemia induced by stopping oral phosphate a significant reduction in measured muscle strength occurred, but the ratios of the intramyocellular levels of phosphocreatine (PCr), adenosine triphosphate (ATP) and inorganic phosphate (Pi) remained unchanged at rest. During exercise these levels changed, as did the intramyocellular pH, but they did not differ from the pattern previously recorded in normal subjects. 3. In four adults with inherited infantile-onset hypophosphataemia (vitamin D-resistant rickets, VDRR) without myopathy, the n.m.r. measurements were normal at rest and during exercise. 4. In one patient with inherited hyperphosphataemia (tumoral calcinosis) the resting PCr: Pi ratio was significantly reduced.

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