Survey of lower urinary tract symptoms in United States women using the new lower urinary tract dysfunction research Network‐Symptom Index 29 (LURN‐SI‐29) and a national research registry

2022 ◽  
Author(s):  
Ariana L. Smith ◽  
Jingwen Chen ◽  
Jean F. Wyman ◽  
Diane K. Newman ◽  
Amanda Berry ◽  
...  
Keyword(s):  
United States ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Symptom Index ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

scholarly journals Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study

2021 ◽  
Author(s):  
Victor P. Andreev ◽  
Margaret E. Helmuth ◽  
Gang Liu ◽  
Abigail R. Smith ◽  
Robert M. Merion ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Heterogeneous Data ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Multidimensional Data ◽  
Data Types ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

ABSTRACTWe present a novel methodology for subtyping of persons with a common clinical symptom complex by integrating heterogeneous continuous and categorical data. We illustrate it by clustering women with lower urinary tract symptoms (LUTS), who represent a heterogeneous cohort with overlapping symptoms and multifactorial etiology. Identifying subtypes within this group would potentially lead to better diagnosis and treatment decision-making. Data collected in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN), a multi-center prospective observational cohort study, included self-reported urinary and non-urinary symptoms, bladder diaries, and physical examination data for 545 women. Heterogeneity in these multidimensional data required thorough and non-trivial preprocessing, including scaling by controls and weighting to mitigate data redundancy, while the various data types (continuous and categorical) required novel methodology using a weighted Tanimoto indices approach. Data domains only available on a subset of the cohort were integrated using a semi-supervised clustering approach. Novel contrast criterion for determination of the optimal number of clusters in consensus clustering was introduced and compared with existing criteria. Distinctiveness of the clusters was confirmed by using multiple criteria for cluster quality, and by testing for significantly different variables in pairwise comparisons of the clusters. Cluster dynamics were explored by analyzing longitudinal data at 3- and 12-month follow-up. Five distinct clusters of women with LUTS were identified using the developed methodology. The clinical relevance of the identified clusters is discussed and compared with the current conventional approaches to the evaluation of LUTS patients. Rationale and thought process are described for selection of procedures for data preprocessing, clustering, and cluster evaluation. Suggestions are provided for minimum reporting requirements in publications utilizing clustering methodology with multiple heterogeneous data domains.

scholarly journals Association of the inflammatory potential of diet and lower urinary tract symptoms among men in the United States

2021 ◽  
Vol 24 (1) ◽  
pp. 72-79
Author(s):  
Xinyang Liao ◽  
Haiyang Bian ◽  
Xiaonan Zheng ◽  
Jianzhong Ai ◽  
Lu Yang ◽  
...  
Keyword(s):  
United States ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
The United States ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Lower Urinary Tract Symptoms are Associated With Depressive Symptoms in White, Black and Hispanic Men in the United States

2008 ◽  
Vol 180 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Edward O. Laumann ◽  
Jeong-han Kang ◽  
Dale B. Glasser ◽  
Raymond C. Rosen ◽  
Culley C. Carson
Keyword(s):  
United States ◽  
Depressive Symptoms ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
The United States ◽  
Urinary Tract Symptoms ◽  
Hispanic Men ◽  
Lower Urinary

scholarly journals A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index‐29 (LURN SI‐29) questionnaire

2019 ◽  
Vol 38 (6) ◽  
pp. 1751-1759
Author(s):  
David Cella ◽  
Abigail R. Smith ◽  
James W. Griffith ◽  
Kathryn E. Flynn ◽  
Catherine S. Bradley ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Outcome Measure ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Symptom Index ◽  
Lower Urinary

scholarly journals PD31-08 A NEW BRIEF LOWER URINARY TRACT SYMPTOMS CLINICAL ASSESSMENT TOOL FOR WOMEN AND MEN: THE LURN SYMPTOM INDEX

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
David Cella ◽  
Abigail R. Smith ◽  
James W. Griffith* ◽  
Kathryn E. Flynn ◽  
Brenda W. Gillespie ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Clinical Assessment ◽  
Lower Urinary Tract ◽  
Assessment Tool ◽  
Symptom Index ◽  
Urinary Tract Symptoms ◽  
Lower Urinary
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