Comparison of different MRI sequences in lesion detection and early response evaluation of diffuse large B-cell lymphoma - a whole-body MRI and diffusion-weighted imaging study

2013 ◽  
Vol 26 (9) ◽  
pp. 1186-1194 ◽  
Author(s):  
Xingchen Wu ◽  
Seyoum Nerisho ◽  
Prasun Dastidar ◽  
Pertti Ryymin ◽  
Ritva Järvenpää ◽  
...  
Keyword(s):  
Cell Lymphoma ◽  
Imaging Study ◽  
B Cell Lymphoma ◽  
Early Response ◽  
Lesion Detection ◽  
Whole Body ◽  
Whole Body Mri ◽  
Large B Cell Lymphoma ◽  
Mri Sequences ◽  
And Diffusion

scholarly journals Diffuse large B-cell lymphoma of the vagina in pregnancy

2020 ◽  
Vol 13 (1) ◽  
pp. e233145
Author(s):  
Nwabundo Anusim ◽  
Filip Ionescu ◽  
Olabisi Afolayan-Oloye ◽  
Susanna S Gaikazian
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Cardiac Activity ◽  
Pelvic Mass ◽  
B Cell Lymphoma ◽  
Whole Body ◽  
Rare Presentation ◽  
Whole Body Mri ◽  
Large B Cell Lymphoma ◽  
Large B Cell

A 28-year-old primigravida was evaluated for complaints of difficulty urinating and pelvic pain of 6-weeks duration. She denied fever, night sweats, weight loss or fatigue. Pelvic ultrasonography revealed a single fetal pole with cardiac activity and a 7 cm mass in the anterior vagina which encased the urethra. The diagnosis of diffuse large B-cell lymphoma germinal centre type was made on analysis of biopsied pelvic mass. Whole body MRI revealed the disease was limited to the vagina. The patient received six cycles of Rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone with significant improvement in her symptoms. Serial ultrasounds over the subsequent months showed appropriate development of the fetus. Whole body MRI after treatment showed decreased size and decreased signal of the primary pelvic mass compatible with favourable treatment response. Challenges in the management of this rare presentation of lymphoma are discussed.

scholarly journals Intravascular large B-Cell lymphoma (IVLBCL) presenting as lumbosacral polyradiculopathy

2015 ◽  
Vol 42 (S1) ◽  
pp. S28-S28 ◽  
Author(s):  
SR Peters ◽  
Z Dastani ◽  
CH Chalk
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Whole Body ◽  
Cardiorespiratory Arrest ◽  
Stool Incontinence ◽  
Large B Cell Lymphoma ◽  
Pet Scanning ◽  
Leg Weakness ◽  
Artery Obstruction ◽  
Lumbar Cord

Background: IVLBCL is potentially treatable but difficult to diagnose. Methods: A case of progressive leg weakness and sphincter dysfunction diagnosed only at autopsy. Results: A 72 year old female presented with three weeks of increasing leg weakness and three days of urine and stool incontinence. Electrophysiological testing showed reduced tibial and peroneal CMAPs, preserved sural SNAPs, and bilateral gastrocnemius fibrillations, consistent with a pre-ganglionic lesion. Lumbosacral MRI with gadolinium showed no abnormalities. CSF was examined three times (protein 1.18-1.25, glucose 2.6-3.1, normal cell count and cytology). Whole-body FDG PET scanning showed hypermetabolic foci at the tongue base and in the mediastinum, but biopsy of both revealed no abnormality. Leg weakness progressed over three months and spread to the arms despite a course of IVIg. Four months later she died of cardiorespiratory arrest. Autopsy revealed the presence of large atypical B-cells within the lumen of small and medium sized vessels in numerous organs. There was evidence of anterior spinal artery obstruction with lymphocytes and anterior horn infarction in the lumbar cord. Conclusions: Although the literature reports that IVLBCL responds well to chemotherapy, this patient illustrates the difficulty of ante-mortem diagnosis. Nerve root biopsy may be warranted in such patients.

scholarly journals FDG-PET as a biomarker for early response in diffuse large B-cell lymphoma as well as in Hodgkin lymphoma? Ready for implementation in clinical practice?

Haematologica ◽  
2016 ◽  
Vol 101 (11) ◽  
pp. 1279-1283 ◽  
Author(s):  
Josée M. Zijlstra ◽  
Coreline N. Burggraaff ◽  
Marie José Kersten ◽  
Sally F. Barrington
Keyword(s):  
Clinical Practice ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Early Response ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Utility of the PET–CT in the evaluation of early response to treatment in the diffuse large B-cell lymphoma. Preliminary results

2012 ◽  
Vol 31 (3) ◽  
pp. 135-141 ◽  
Author(s):  
M. Cortés Romera ◽  
C. Gámez Cenzano ◽  
A.P. Caresia Aróztegui ◽  
J. Martín-Comín ◽  
E. González-Barca ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Early Response ◽  
Response To Treatment ◽  
Preliminary Results ◽  
Large B Cell Lymphoma ◽  
Pet Ct ◽  
Large B Cell

Diffuse Large B-Cell Lymphoma Infiltrating Limb Bones With a Few Lymphadenopathy Revealed on Whole-Body 18F-FDG PET/CT

2015 ◽  
Vol 40 (7) ◽  
pp. 569-571 ◽  
Author(s):  
Lin Qiu ◽  
Yue Chen ◽  
Zhanwen Huang ◽  
Yan Zhu ◽  
Qinglian Wen
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Whole Body ◽  
Limb Bones ◽  
Large B Cell Lymphoma ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Large B Cell

scholarly journals Diagnostic accuracy of pelvic magnetic resonance imaging for the assessment of bone marrow involvement in diffuse large B-cell lymphoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252226
Author(s):  
Qing Ke ◽  
Cheng-Cheng Liao ◽  
Xiao-Hong Tan ◽  
Bao-Ping Guo ◽  
Hong Cen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Lymphoma ◽  
Bone Marrow Involvement ◽  
B Cell Lymphoma ◽  
Diagnostic Value ◽  
Whole Body ◽  
Pelvic Mri ◽  
Pelvic Magnetic Resonance Imaging ◽  
Large B Cell Lymphoma ◽  
Pet Ct

Purpose We investigated the efficacy of pelvic magnetic resonance imaging (MRI) in the diagnosis of bone marrow involvement (BMinv) in diffuse large B-cell lymphoma (DLBCL) patients. Patients and methods This was a retrospective study of data from a previous study (NCT02733887). We included 171 patients who underwent bone marrow biopsy (BMB) and bone marrow smear (BMS), pelvic MRI, and whole-body positron emission tomography-computed tomography (PET/CT) from January 2016 to December 2019 at a single center. BMB/BMS and whole-body PET/CT results were used as reference standards against which we calculated the diagnostic value of pelvic MRI for BMinv in DLBCL patients. A chi-square test was used to compare detection rates, and a receiver operating characteristic curve was used to evaluate diagnostic value of pelvic MRI. Propensity-score matching was performed according to clinical information, and Kaplan-Meier curves were constructed to compare progression-free survival (PFS) and overall survival (OS) of patients. Results The BMinv detection rate of pelvic MRI (42/171) was higher (P = 0.029) than that of BMB/BMS (25/171), and similar to that of PET/CT (44/171; P = 0.901). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of pelvic MRI were 83.33%, 98.37%, 94.15%, 95.24%, and 93.80%, respectively. Median PFS values were as follows: BMB/BMS-positive, 17.8 months vs. BMB/BMS-negative, 26.9 months (P = 0.092); PET/CT-positive, 24.8 months vs. PET/CT-negative, 33.0 months (P = 0.086); pelvic MRI-positive, 24.9 months vs. pelvic MRI-negative, 33.1 months (P<0.001). Median OS values were as follows: BMB/BMS-positive, 22.3 months vs. BMB/BMS-negative, 29.8 months (P = 0.240); PET/CT-positive, 27.9 months vs. PET/CT-negative, 33.9 months (P = 0.365); pelvic MRI-positive, 27.3 months vs. pelvic MRI-negative, 35.8 months (P = 0.062). Conclusion Pelvic MRI is effective for detecting BMinv in DLBCL patients, providing a more accurate indication of PFS than BMB/BMS and PET/CT do. It may ultimately be used to improve the accuracy of clinical staging, guide patient treatment, and evaluate prognosis.

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