The nicotinic receptor ligand binding domain

2002 ◽  
Vol 53 (4) ◽  
pp. 431-446 ◽  
Author(s):  
Steven M. Sine
Keyword(s):  
Ligand Binding ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand

scholarly journals Ligand-Induced Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain

2005 ◽  
Vol 88 (4) ◽  
pp. 2564-2576 ◽  
Author(s):  
Richard H. Henchman ◽  
Hai-Long Wang ◽  
Steven M. Sine ◽  
Palmer Taylor ◽  
J. Andrew McCammon
Keyword(s):  
Ligand Binding ◽  
Conformational Change ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand

scholarly journals Curariform Antagonists Bind in Different Orientations to the Nicotinic Receptor Ligand Binding Domain

2003 ◽  
Vol 278 (34) ◽  
pp. 32284-32291 ◽  
Author(s):  
Hai-Long Wang ◽  
Fan Gao ◽  
Nina Bren ◽  
Steven M. Sine
Keyword(s):  
Ligand Binding ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand

scholarly journals Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

2013 ◽  
Vol 454 (2) ◽  
pp. 303-310 ◽  
Author(s):  
Sun Huang ◽  
Shu-Xing Li ◽  
Nina Bren ◽  
Kevin Cheng ◽  
Ryan Gomoto ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Acetylcholine Receptor ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand

The crystal structure of α-bungarotoxin bound to a chimaeric α7 acetylcholine receptor ligand-binding domain reveals the following major stabilizing interaction: Arg36 and Phe32 from finger II of α-bungarotoxin form a p-cation stack that aligns edge-to-face with Tyr184 from α7.

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