scholarly journals Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

2012 ◽  
Vol 20 (19) ◽  
pp. 5992-6002 ◽  
Author(s):  
Atilla Akdemir ◽  
Ewald Edink ◽  
Andrew J. Thompson ◽  
Sarah C.R. Lummis ◽  
Albert J. Kooistra ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
In Silico ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligands ◽  
In Silico Screening ◽  
Receptor Ligand

scholarly journals Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

2013 ◽  
Vol 454 (2) ◽  
pp. 303-310 ◽  
Author(s):  
Sun Huang ◽  
Shu-Xing Li ◽  
Nina Bren ◽  
Kevin Cheng ◽  
Ryan Gomoto ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Acetylcholine Receptor ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand

The crystal structure of α-bungarotoxin bound to a chimaeric α7 acetylcholine receptor ligand-binding domain reveals the following major stabilizing interaction: Arg36 and Phe32 from finger II of α-bungarotoxin form a p-cation stack that aligns edge-to-face with Tyr184 from α7.

Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain

ChemBioChem ◽  
2010 ◽  
Vol 11 (16) ◽  
pp. 2251-2254 ◽  
Author(s):  
Sabine Möcklinghoff ◽  
Rolf Rose ◽  
Maëlle Carraz ◽  
Arie Visser ◽  
Christian Ottmann ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Estrogen Receptor ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Synthesis And Crystal Structure ◽  
Estrogen Receptor Ligand

scholarly journals Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Cell ◽  
2002 ◽  
Vol 110 (1) ◽  
pp. 93-105 ◽  
Author(s):  
Randy K. Bledsoe ◽  
Valerie G. Montana ◽  
Thomas B. Stanley ◽  
Chris J. Delves ◽  
Christopher J. Apolito ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Glucocorticoid Receptor ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Receptor Dimerization

scholarly journals The 1.1 Å Crystal Structure of Human TGF-β Type II Receptor Ligand Binding Domain

Structure ◽  
2002 ◽  
Vol 10 (7) ◽  
pp. 913-919 ◽  
Author(s):  
Christian C Boesen ◽  
Sergei Radaev ◽  
Shawn A Motyka ◽  
Apisit Patamawenu ◽  
Peter D Sun
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Type Ii ◽  
Receptor Ligand

scholarly journals Ligand-Induced Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain

2005 ◽  
Vol 88 (4) ◽  
pp. 2564-2576 ◽  
Author(s):  
Richard H. Henchman ◽  
Hai-Long Wang ◽  
Steven M. Sine ◽  
Palmer Taylor ◽  
J. Andrew McCammon
Keyword(s):  
Ligand Binding ◽  
Conformational Change ◽  
Nicotinic Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand
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