Reactions of ionized dibutyl ether

1994 ◽  
Vol 29 (12) ◽  
pp. 791-805 ◽  
Author(s):  
Richard D. Bowen ◽  
Dennis Suh ◽  
Johan K. Terlouw
Keyword(s):  
2021 ◽  
Vol 223 ◽  
pp. 98-109
Author(s):  
Khaiyom Hakimov ◽  
Farhan Arafin ◽  
Khalid Aljohani ◽  
Khalil Djebbi ◽  
Erik Ninnemann ◽  
...  

Synthesis ◽  
2020 ◽  
Author(s):  
Ghenia Bentabed-Ababsa ◽  
Laurent Picot ◽  
Florence Mongin ◽  
Salima Bouarfa ◽  
William Erb ◽  
...  

Abstract N-Arylation of various 2-acylated anilines with different electron-rich heteroaryl iodides (2- and 3-iodothiophenes, 2- and 3-iodobenzothiophenes­, 2-iodobenzofuran) was achieved by using activated copper and potassium carbonate in dibutyl ether at reflux. The reactivity of the different heteroaryl iodides and anilines employed was discussed and rationalized on the basis of their electronic features. Subsequent cyclization by aromatic electrophilic substitution easily took place in the case of C2-free (benzo)thienyl or C3-free (benzo)furyl derivatives­, affording original tri- and tetracycles. The antiproliferative activity of most of them was evaluated in A2058 melanoma cells and revealed four chlorinated tetracycles as effective growth inhibitors.


2009 ◽  
Vol 54 (8) ◽  
pp. 2341-2342 ◽  
Author(s):  
Fernando Aguilar ◽  
Fatima E. M. Alaoui ◽  
Cristina Alonso-Tristán ◽  
José J. Segovia ◽  
Miguel A. Villamañán ◽  
...  

2003 ◽  
Vol 48 (6) ◽  
pp. 1517-1520 ◽  
Author(s):  
Teresa Treszczanowicz ◽  
Teresa Kasprzycka-Guttman ◽  
Andrzej J. Treszczanowicz

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