scholarly journals Design and Synthesis of Hsp90 Inhibitors with B‐Raf and PDHK1 Multi‐Target Activity

ChemistryOpen ◽  
2021 ◽  
Author(s):  
Luca Pinzi ◽  
Francesca Foschi ◽  
Michael S. Christodoulou ◽  
Daniele Passarella ◽  
Giulio Rastelli
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis ◽  
Target Activity

Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors

2016 ◽  
Vol 121 ◽  
pp. 272-282 ◽  
Author(s):  
Chuanpeng Liang ◽  
Huilin Hao ◽  
Xingkang Wu ◽  
Zhenyu Li ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis

scholarly journals Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives

2010 ◽  
Vol 18 (18) ◽  
pp. 6822-6856 ◽  
Author(s):  
Robert P. Sellers ◽  
Leslie D. Alexander ◽  
Victoria A. Johnson ◽  
Chun-Chieh Lin ◽  
Jeremiah Savage ◽  
...  
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis ◽  
Sansalvamide A

scholarly journals Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors

2014 ◽  
Vol 22 (2) ◽  
pp. 892-905 ◽  
Author(s):  
Atsushi Suda ◽  
Ken-ichi Kawasaki ◽  
Susumu Komiyama ◽  
Yoshiaki Isshiki ◽  
Dong-Oh Yoon ◽  
...  
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis

Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors

2012 ◽  
Vol 22 (2) ◽  
pp. 1136-1141 ◽  
Author(s):  
Atsushi Suda ◽  
Hiroshi Koyano ◽  
Tadakatsu Hayase ◽  
Kihito Hada ◽  
Ken-ichi Kawasaki ◽  
...  
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis

scholarly journals Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

2019 ◽  
Vol 63 (5) ◽  
pp. 2139-2180 ◽  
Author(s):  
David S. Huang ◽  
Emmanuelle V. LeBlanc ◽  
Tanvi Shekhar-Guturja ◽  
Nicole Robbins ◽  
Damian J. Krysan ◽  
...  
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis

Design and synthesis of 3′,5′-ansa-adenosines as potential Hsp90 inhibitors

2009 ◽  
Vol 50 (36) ◽  
pp. 5102-5106 ◽  
Author(s):  
Kazuhiro Muranaka ◽  
Satoshi Ichikawa ◽  
Akira Matsuda
Keyword(s):  
Hsp90 Inhibitors ◽  
Design And Synthesis

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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