Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours

2002 ◽  
Vol 199 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Raymond Lai ◽  
George Z Rassidakis ◽  
L Jeffrey Medeiros ◽  
Vasiliki Leventaki ◽  
Micheal Keating ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

2006 ◽  
Vol 30 (8) ◽  
pp. 923-934 ◽  
Author(s):  
Jordi Camps ◽  
Itziar Salaverria ◽  
Maria J. Garcia ◽  
Esther Prat ◽  
Sílvia Beà ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Genomic Imbalances ◽  
Karyotypic Variability ◽  
Mantle Cell

Mantle cell lymphoma cell lines show no evident immunoglobulin heavy chain stereotypy but frequent light chain stereotypy

2013 ◽  
Vol 54 (8) ◽  
pp. 1747-1755 ◽  
Author(s):  
Chiara Pighi ◽  
Stefano Barbi ◽  
Anna Bertolaso ◽  
Alberto Zamò
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Heavy Chain ◽  
Light Chain ◽  
Cell Lymphoma ◽  
Immunoglobulin Heavy Chain ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

Combining Ibrutinib with Chk1 Inhibitors Synergistically Targets Mantle Cell Lymphoma Cell Lines

2018 ◽  
Vol 13 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Valentina Restelli ◽  
Monica Lupi ◽  
Micaela Vagni ◽  
Rosaria Chilà ◽  
Francesco Bertoni ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

scholarly journals Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

Mobile DNA ◽  
2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Witold Tatkiewicz ◽  
James Dickie ◽  
Franchesca Bedford ◽  
Alexander Jones ◽  
Mark Atkin ◽  
...  
Keyword(s):  
Protein Expression ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Human Endogenous Retrovirus ◽  
Rna Seq ◽  
Tissue Specific ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

Abstract Background The cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage of endogenous retroviruses is a potentially attractive tumour-associated antigen for anti-cancer immunotherapy. The human genome contains around 100 integrated copies (called proviruses or loci) of the HERV-K(HML-2) virus and we argue that it is important for therapy development to know which and how many of these contribute to protein expression, and how this varies across tissues. We measured relative provirus expression in HERV-K(HML-2), using enriched RNA-Seq analysis with both short- and long-read sequencing, in three Mantle Cell Lymphoma cell lines (JVM2, Granta519 and REC1). We also confirmed expression of the Env protein in two of our cell lines using Western blotting, and analysed provirus expression data from all other relevant published studies. Results Firstly, in both our and other reanalysed studies, approximately 10% of the transcripts mapping to HERV-K(HML-2) came from Env-encoding proviruses. Secondly, in one cell line the majority of the protein expression appears to come from one provirus (12q14.1). Thirdly, we find a strong tissue-specific pattern of provirus expression. Conclusions A possible dependency of Env expression on a single provirus, combined with the earlier observation that this provirus is not present in all individuals and a general pattern of tissue-specific expression among proviruses, has serious implications for future HERV-K(HML-2)-targeted immunotherapy. Further research into HERV-K(HML-2) as a possible tumour-associated antigen in blood cancers requires a more targeted, proteome-based, screening protocol that will consider these polymorphisms within HERV-K(HML-2). We include a plan (and necessary alignments) for such work.

scholarly journals Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines

2012 ◽  
Vol 40 (8) ◽  
pp. 646-656.e2 ◽  
Author(s):  
Ana Lopez-Campistrous ◽  
Xiaohua Song ◽  
Adam J. Schrier ◽  
Paul A. Wender ◽  
Nancy A. Dower ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell ◽  
Induced Apoptosis

scholarly journals A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines

2015 ◽  
Vol 87 (4) ◽  
pp. 285-288 ◽  
Author(s):  
Sophie Maïga ◽  
Carole Brosseau ◽  
Géraldine Descamps ◽  
Christelle Dousset ◽  
Patricia Gomez-Bougie ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Flow Cytometry ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell ◽  
Simple Flow

The cytotoxic effects of bendamustine in combination with cytarabine in mantle cell lymphoma cell lines

2012 ◽  
Vol 48 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Carlo Visco ◽  
Silvia Castegnaro ◽  
Katia Chieregato ◽  
Martina Bernardi ◽  
Elena Albiero ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Cytotoxic Effects ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

scholarly journals Small interfering RNAs targeting cyclin D1 and cyclin D2 enhance the cytotoxicity of chemotherapeutic agents in mantle cell lymphoma cell lines

2011 ◽  
Vol 52 (11) ◽  
pp. 2148-2154 ◽  
Author(s):  
Katrin Tiemann ◽  
Jessica V. Alluin ◽  
Anja Honegger ◽  
Pritsana Chomchan ◽  
Shikha Gaur ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Chemotherapeutic Agents ◽  
Lymphoma Cell ◽  
Small Interfering Rnas ◽  
Cyclin D2 ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell
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