scholarly journals Outcomes of matched sibling donor bone marrow transplantation in children using single-agent calcineurin inhibitors as prophylaxis for graft versus host disease

2017 ◽  
Vol 65 (1) ◽  
pp. e26726 ◽  
Author(s):  
Caitlin W. Elgarten ◽  
Danielle E. Arnold ◽  
Nancy J. Bunin ◽  
Alix E. Seif
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Graft Versus Host Disease ◽  
Marrow Transplantation ◽  
Single Agent ◽  
Calcineurin Inhibitors ◽  
Host Disease ◽  
Graft Versus Host ◽  
Donor Bone Marrow ◽  
Matched Sibling

Lack of correlation of MLC reactivity with acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation

1996 ◽  
Vol 49 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Miriam Segall ◽  
Harriet Noreen ◽  
Linda Edwins ◽  
Robert Haake ◽  
Xiao Ou Shu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Graft Versus Host Disease ◽  
Marrow Transplantation ◽  
Unrelated Donor ◽  
Host Disease ◽  
Graft Versus Host ◽  
Donor Bone Marrow ◽  
Acute Graft

High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation

2003 ◽  
Vol 76 (12) ◽  
pp. 1758-1762 ◽  
Author(s):  
Margaret L. MacMillan ◽  
Gretchen A. Radloff ◽  
William R. Kiffmeyer ◽  
Todd E. DeFor ◽  
Daniel J. Weisdorf ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Graft Versus Host Disease ◽  
Marrow Transplantation ◽  
Interleukin 2 ◽  
Unrelated Donor ◽  
Host Disease ◽  
Graft Versus Host ◽  
Donor Bone Marrow ◽  
Acute Graft

scholarly journals HLA-matched sibling bone marrow transplantation for β-thalassemia major

Blood ◽  
2011 ◽  
Vol 117 (5) ◽  
pp. 1745-1750 ◽  
Author(s):  
Mitchell Sabloff ◽  
Mammen Chandy ◽  
Zhiwei Wang ◽  
Brent R. Logan ◽  
Ardeshir Ghavamzadeh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Graft Versus Host Disease ◽  
Marrow Transplantation ◽  
Graft Failure ◽  
Thalassemia Major ◽  
Host Disease ◽  
Risk Class ◽  
Graft Versus Host ◽  
Matched Sibling

Abstract We describe outcomes after human leukocyte antigen-matched sibling bone marrow transplantation (BMT) for 179 patients with β-thalassemia major. The median age at transplantation was 7 years and the median follow-up was 6 years. The distribution of Pesaro risk class I, II, and III categories was 2%, 42%, and 36%, respectively. The day 30 cumulative incidence of neutrophil recovery and day 100 platelet recovery were 90% and 86%, respectively. Seventeen patients had graft failure, which was fatal in 11. Six of 9 patients with graft failure are alive after a second transplantation. The day 100 probability of acute graft-versus-host disease and 5-year probability of chronic graft-versus-host disease was 38% and 13%, respectively. The 5-year probabilities of overall- and disease-free survival were 91% and 88%, respectively, for patients with Pesaro risk class II, and 64% and 62%, respectively, for Pesaro risk class III. In multivariate analysis, mortality risks were higher in patients 7 years of age and older and those with hepatomegaly before BMT. The leading causes of death were interstitial pneumonitis (n = 7), hemorrhage (n = 8), and veno-occlusive disease (n = 6). Proceeding to BMT in children younger than 7 years before development of end-organ damage, particularly in the liver, should improve results after BMT for β-thalassemia major.

RISK FACTORS FOR ACUTE GRAFT-VERSUS-HOST DISEASE IN HISTOCOMPATIBLE DONOR BONE MARROW TRANSPLANTATION

1991 ◽  
Vol 51 (6) ◽  
pp. 1197-1202 ◽  
Author(s):  
DANIEL WEISDORF ◽  
ROBERT HAKKE ◽  
BRUCE BLAZAR ◽  
WESLEY MILLER ◽  
PHILIP MCGLAVE ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Graft Versus Host Disease ◽  
Marrow Transplantation ◽  
Host Disease ◽  
Graft Versus Host ◽  
Donor Bone Marrow ◽  
Acute Graft
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