Immature teratoma of the ovary associated with Cowden syndrome

Abstract Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.

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Lhermitte–Duclos Disease: Incidental Finding in Traumatic Cerebral Hemorrhage

Indian Journal of Neurotrauma ◽

10.1055/s-0041-1729136 ◽

2021 ◽

Author(s):

Hemant Kumar Beniwal ◽

Thatikonda Satish ◽

Gollapudi Prakash Rao ◽

Musali Siddartha Reddy ◽

Srikrishnaaditya Manne

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Intracranial Pressure ◽

Cerebellar Ataxia ◽

Cerebral Hemorrhage ◽

Incidental Finding ◽

Cowden Syndrome ◽

Young Female ◽

Resonance Imaging ◽

Increased Intracranial Pressure

AbstractLhermitte–Duclos disease, also known as dysplastic cerebellar gangliocytoma, is a rare hamartomatous tumor localized in cerebellum. An association with Cowden syndrome is observed in 50% of cases who present with symptoms of increased intracranial pressure and cerebellar ataxia. These patients have specific magnetic resonance imaging and histopathological findings. Surgical resection is the treatment of choice. Here, we report a case of a young female with traumatic frontal hemorrhage associated with Lhermitte–Duclos disease.

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Cowden syndrome

BDJ ◽

10.1038/s41415-021-2852-z ◽

2021 ◽

Vol 230 (6) ◽

pp. 362-362

Author(s):

Reena Wadia

Keyword(s):

Cowden Syndrome

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PTEN Hamartoma Tumor Syndrome/Cowden Syndrome: Genomics, Oncogenesis, and Imaging Review for Associated Lesions and Malignancy

Cancers ◽

10.3390/cancers13133120 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3120

Author(s):

David D. Dragoo ◽

Ahmed Taher ◽

Vincenzo K. Wong ◽

Ahmed Elsaiey ◽

Nikita Consul ◽

...

Keyword(s):

Autosomal Dominant ◽

Malignant Tumors ◽

Cowden Syndrome ◽

Benign Tumors ◽

Imaging Findings ◽

Pten Hamartoma Tumor Syndrome ◽

Associated Lesions ◽

Tumor Recognition ◽

Integral Role ◽

Early Tumor

PTEN hamartoma tumor syndrome/Cowden syndrome (CS) is a rare autosomal dominant syndrome containing a germline PTEN mutation that leads to the development of multisystem hamartomas and oncogenesis. Benign tumors such as Lhermitte–Duclos disease and malignant tumors involving the breast, thyroid, kidneys, and uterus are seen in CS. Radiologists have an integral role in the comanagement of CS patients. We present the associated imaging findings and imaging screening recommendations. Knowledge of the types of cancers commonly seen in CS and their imaging findings can aid in early tumor recognition during cancer screening to help ensure near-normal life spans in CS patients.

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