Postnatal placental confirmation of trisomy 2 and trisomy 16 detected at chorionic villus sampling: A possible association with intrauterine growth retardation and elevated maternal serum alpha-fetoprotein

1992 ◽  
Vol 12 (3) ◽  
pp. 157-162 ◽  
Author(s):  
J. S. Fryburg ◽  
M. S. Dimaio ◽  
M. J. Mahoney
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Chorionic Villus ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Chorionic Villus Sampling ◽  
Trisomy 16 ◽  
Intrauterine Growth ◽  
Serum Alpha Fetoprotein

Studies on the prenatal chromosomal analysis and the changes of maternal serum alpha-fetoprotein following chorionic villus sampling

1991 ◽  
Vol 32 (4) ◽  
pp. 292 ◽  
Author(s):  
Young Ho Yang ◽  
Meong Sun Lee ◽  
Yong Won Park ◽  
Sei Kwang Kim ◽  
Hae Ree Sung ◽  
...  
Keyword(s):  
Chorionic Villus ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Chromosomal Analysis ◽  
Chorionic Villus Sampling ◽  
Serum Alpha Fetoprotein

The effect of chorionic villus sampling on the number of fetal cells isolated from maternal blood and on maternal serum alpha-fetoprotein levels

1997 ◽  
Vol 17 (10) ◽  
pp. 953-959 ◽  
Author(s):  
Mieke W. J. C. Jansen ◽  
Helen Brandenburg ◽  
Hajo I. J. Wildschut ◽  
Anton C. M. Martens ◽  
Adriana M. Hagenaars ◽  
...  
Keyword(s):  
Chorionic Villus ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Chorionic Villus Sampling ◽  
Fetal Cells ◽  
Serum Alpha Fetoprotein

Mid-trimester maternal serum and amniotic fluid biomarkers for the prediction of preterm delivery and intrauterine growth retardation

2014 ◽  
Vol 40 (6) ◽  
pp. 1540-1546 ◽  
Author(s):  
A. Seval Ozgu-Erdinc ◽  
Sabri Cavkaytar ◽  
Ayla Aktulay ◽  
Umran Buyukkagnici ◽  
Salim Erkaya ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Preterm Delivery ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Maternal Serum ◽  
Intrauterine Growth

scholarly journals Intrauterine Growth Retardation Fetus with Trisomy 16 Mosaicism

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Takol Chareonsirisuthigul ◽  
Suchin Worawichawong ◽  
Rachanee Parinayok ◽  
Patama Promsonthi ◽  
Budsaba Rerkamnuaychoke
Keyword(s):  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Fetal Heart ◽  
Cytogenetic Study ◽  
Normal Karyotype ◽  
Internal Organs ◽  
Normal Morphology ◽  
Trisomy 16 ◽  
Intrauterine Growth ◽  
Mosaic Trisomy

Fetal trisomy 16 is considered uniformly lethal early in gestation. It has been reported to be associated with the variability of clinical features and outcomes. Mosaic trisomy 16 leads to a high risk of abnormality in prenatal cases. Intrauterine growth retardation (IUGR) is a common outcome of mosaic trisomy 16. Herein, we report on the case of Thai male IUGR fetus with trisomy 16 mosaicism. The fetal body was too small. Postmortem investigation of placenta revealed the abnormality including small placenta with furcated cord insertion and single umbilical cord artery. Cytogenetic study demonstrated trisomy 16 that was found 100% in placenta and only 16% in the fetal heart while other organs had normal karyotype. In addition, cardiac and other internal organs examination revealed normal morphology.

Outcome in Infants Born to Mothers With Unexplained Elevations of Maternal Serum α-Fetoprotein

PEDIATRICS ◽  
1986 ◽  
Vol 77 (4) ◽  
pp. 582-586
Author(s):  
Barbara K. Burton ◽  
Robert G. Dillard
Keyword(s):  
Adverse Events ◽  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Growth Retardation ◽  
Congenital Anomalies ◽  
Intrauterine Growth Retardation ◽  
Maternal Serum ◽  
Placental Barrier ◽  
Intrauterine Growth

The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum α-fetoprotein was studied. Elevated maternal serum α-fetoprotein with normal amniotic fluid α-fetoprotein was found to be associated with an increased incidence of intrauterine growth retardation and nonneural tube congenital anomalies. There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum α-fetoprotein. It is speculated that adverse events occurring early in gestation may simultaneously result in congenital anomalies and subsequently elevated maternal serum α-fetoprotein, perhaps through disruption of the normal placental barrier between the fetal and maternal circulations.

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