scholarly journals Role of the second-trimester ‘genetic sonogram’ for Down syndrome screen in the era of first-trimester screening and noninvasive prenatal testing

2014 ◽  
Vol 34 (6) ◽  
pp. 511-517 ◽  
Author(s):  
Anthony O. Odibo ◽  
Alessandro Ghidini
Keyword(s):  
Down Syndrome ◽  
Prenatal Testing ◽  
First Trimester ◽  
Second Trimester ◽  
First Trimester Screening ◽  
Noninvasive Prenatal Testing ◽  
Trimester Screening

First-trimester screening for Down syndrome; the role of nasal bone assessment in the Korean population

2007 ◽  
Vol 27 (9) ◽  
pp. 830-834 ◽  
Author(s):  
Min Hoan Moon ◽  
Jeong Yeon Cho ◽  
Yu Mi Lee ◽  
Sung Il Jung ◽  
Jae Hyug Yang ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Korean Population ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Bone Assessment

Noninvasive Prenatal Testing Decreased Diagnostic Testing but Not First-Trimester Screening

2014 ◽  
Vol 123 ◽  
pp. 88S
Author(s):  
Sebastian Larion ◽  
Malgorzata Mlynarczyk ◽  
Letty Romary ◽  
Alfred Z. Abuhamad ◽  
Steven L. Warsof
Keyword(s):  
Diagnostic Testing ◽  
Prenatal Testing ◽  
First Trimester ◽  
First Trimester Screening ◽  
Noninvasive Prenatal Testing ◽  
Trimester Screening

scholarly journals Fetal Down syndrome screening models for developing countries; Part I: Performance of Maternal Serum Screening

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chanane Wanapirak ◽  
Wirawit Piyamongkol ◽  
Supatra Sirichotiyakul ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupundit ◽  
...  
Keyword(s):  
Developing Countries ◽  
Down Syndrome ◽  
Reference Range ◽  
First Trimester ◽  
Maternal Serum ◽  
Second Trimester ◽  
First Trimester Screening ◽  
Maternal Serum Screening ◽  
Serum Screening ◽  
Trimester Screening

Abstract Background To identify the performance of fetal Down syndrome (DS) screening for developing countries. Methods A prospective study on MSS (maternal serum screening) with complete follow-ups (n = 41,924) was conducted in 32 network hospitals in the northern part of Thailand. Various models of MSS were tested for performance. Results MSS based on Caucasian reference range resulted in very high false positive rate (FPR; 13%) in our country, compared to the rate of 7.8% with our own (Thai) reference range, whereas the detection rate was comparable. As individual screening, C-S (contingent first trimester screening including PAPP-A, and free beta-hCG, classified as a) high risk [> 1:30], indicated for invasive diagnosis; b) intermediate risk [1:30–1500], indicated for STS; and c) low risk [< 1:1500], need no further tests.) was the most effective model (sensitivity 84.9%, FPR 7.7%) but nearly one-third needed the second trimester test (STS) because of intermediate results. Additionally, about one-third had their first visits in the second trimester and had no chance of FTS (first trimester screening). C-S plus STS had a sensitivity of 82.4% and FPR 8.1% whereas independent first and second trimester screening model (I-S) gave the sensitivity of 78.4% and FPR of 7.5% but was much more convenient and practical. Conclusion C-S plus STS was the most effective models while I-S model was also effective and may be better for developing countries because of its simplicity and feasibility.

The Role of Second-Trimester Serum Screening in the Post–First-Trimester Screening Era

2010 ◽  
Vol 30 (3) ◽  
pp. 667-676 ◽  
Author(s):  
Alireza A. Shamshirsaz ◽  
Peter Benn ◽  
James F.X. Egan
Keyword(s):  
First Trimester ◽  
Second Trimester ◽  
First Trimester Screening ◽  
Serum Screening ◽  
Trimester Screening
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