Impact of a shift in nuchal translucency measurements on the detection rate of first-trimester Down syndrome screening: A population-based study

2018 ◽  
Vol 38 (2) ◽  
pp. 106-109 ◽  
Author(s):  
Nicolas Fries ◽  
Laurent J. Salomon ◽  
Françoise Muller ◽  
Sophie Dreux ◽  
Véronique Houfflin-Debarge ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Detection Rate ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Population Based ◽  
Population Based Study ◽  
Down Syndrome Screening

scholarly journals Second-trimester Maternal Serum Quadruple Test for Down Syndrome Screening: A Taiwanese Population-based Study

2010 ◽  
Vol 49 (1) ◽  
pp. 30-34 ◽  
Author(s):  
S.W. Steven Shaw ◽  
Shin-Yu Lin ◽  
Chia-Hui Lin ◽  
Yi-Ning Su ◽  
Po-Jen Cheng ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Population Based ◽  
Maternal Serum ◽  
Second Trimester ◽  
Taiwanese Population ◽  
Population Based Study ◽  
Down Syndrome Screening

scholarly journals OP01.31: Incorporation of nasal bone assessment into first-trimester Down syndrome screening with free beta hCG, PAPP-A and nuchal translucency

2006 ◽  
Vol 28 (4) ◽  
pp. 420-421
Author(s):  
F. Orlandi ◽  
C. Rossi ◽  
E. Orlandi ◽  
T. W. Hallahan ◽  
V. J. Macri ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Beta Hcg ◽  
Bone Assessment ◽  
Down Syndrome Screening

First-Trimester Down Syndrome Screening Using Dried Blood Biochemistry and Nuchal Translucency

2000 ◽  
Vol 96 (2) ◽  
pp. 207-213 ◽  
Author(s):  
DAVID A. KRANTZ ◽  
TERRENCE W. HALLAHAN ◽  
FRANCESCO ORLANDI ◽  
PHILIP BUCHANAN ◽  
JOHN W. LARSEN ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Blood Biochemistry ◽  
Down Syndrome Screening

scholarly journals First trimester Down syndrome screening by nuchal translucency in Thai population

2001 ◽  
Vol 18 ◽  
pp. P19-P19
Author(s):  
Panyu Panburana ◽  
S. Ajjimakorn ◽  
P. Tungkajiwangoon ◽  
A. Jaowisidha
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Thai Population ◽  
Down Syndrome Screening

scholarly journals P10.04: Down syndrome screening in the first trimester using maternal serum markers and nuchal translucency-five years' experience

2004 ◽  
Vol 24 (3) ◽  
pp. 321-321
Author(s):  
V. Frisová ◽  
L. Krofta ◽  
I. Kuèerová ◽  
O. Benešová ◽  
A. Hujová ◽  
...  
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Serum Markers ◽  
Maternal Serum ◽  
Down Syndrome Screening

scholarly journals First Trimester Genetic Sonogram for Screening Fetal Down Syndrome: a Population-based Study

2020 ◽  
Author(s):  
Kuntharee Traisrisilp ◽  
Supatra Sirichotiyakul ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupun ◽  
Suchaya Luewan ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
False Positive ◽  
Detection Rate ◽  
False Positive Rate ◽  
Nasal Bone ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ductus Venosus ◽  
Positive Rate

Abstract Background: To evaluate the performance of first trimester sonomarkers in the detection of fetal Down syndrome among Thai pregnant womenMethods: Pregnant women at 11-13+6 weeks’ gestation underwent ultrasound examination for assessment of nuchal translucency (NT), nasal bone (NB), tricuspid regurgitation (TR), and abnormal ductus venosus (aDV) Doppler waveforms. The women were followed up for final outcomes. Fetal abnormalities other than trisomy 21 were excluded. The performances of each sonomarker and their combinations in predicting fetal Down syndrome were calculated.Results: A total of 7,820 pregnant women meeting the inclusion criteria were available for analysis, including 20 cases with fetal Down syndrome and 7,800 unaffected cases. Of the four sonomarkers, NT, as a single sonomarker, had the highest detection rate (55.0% at a false positive rate of about 5%), whereas the remaining single sonomarkers had low detection rate (15-20%). The combination of all sonomarkers had the highest detection rate of 70% but the false positive rate was as high as 10.8%. The combination of NT and NB had a detection rate of 60% with an acceptable false positive rate of 6.9%, whereas the other combinations yielded relatively high false positive rates. Conclusion: The first trimester genetic sonogram in screening for Down syndrome among Asian women is acceptably effective and may be offered to some selected groups of the population. NT is the best sonomarker with a detection rate of 55% at 5% false positive rate and its combination with NB can improve performance with minimal increase in false positive rate.

First-trimester serum biomarker screening for fetal Down syndrome as a predictor of preterm delivery: a population-based study

2018 ◽  
Vol 33 (10) ◽  
pp. 1717-1724
Author(s):  
Weerawich Pornwattanakrilert ◽  
Ratanaporn Sekararithi ◽  
Chanane Wanapirak ◽  
Supatra Sirichotiyakul ◽  
Fuanglada Tongprasert ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Preterm Delivery ◽  
First Trimester ◽  
Population Based ◽  
Serum Biomarker ◽  
Population Based Study
Sign in / Sign up

Export Citation Format

Share Document