Novel poly(sulfobetaine methacrylate) based carriers as potential ocular drug delivery systems for timolol maleate

2022 ◽  
Author(s):  
Denitsa Nikolova ◽  
Konstans Ruseva ◽  
Christo Tzachev ◽  
Lachezar Christov ◽  
Elena Vassileva
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Timolol Maleate

Nanoscale Drug Delivery Systems for Glaucoma: Experimental and In Silico Advances

2020 ◽  
Vol 20 ◽  
Author(s):  
Smriti Sharma ◽  
Vinayak Bhatia
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
The Body ◽  
Single Wall Carbon Nanotubes ◽  
Blood Retinal Barrier ◽  
Novel Drugs ◽  
Blood Aqueous Barrier

: In this review nanoscale based drug delivery systems particularly in relevance to the antiglaucoma drugs have been discussed. In addition to that, the latest computational/in silico advances in this field are examined in brief. Using nanoscale materials for drug delivery, is an ideal option to target tumours and drug can be released at areas of the body where traditional drugs may fail to act. Nanoparticles, polymeric nanomaterials, single-wall carbon nanotubes (SWCNTs), quantum dots (QDs), liposomes and graphene are the most important nanomaterials used for drug delivery. Ocular drug delivery is one of the most common and difficult tasks faced by pharmaceutical scientists because of many challenges like circumventing the blood–retinal barrier, corneal epithelium and the blood–aqueous barrier. Authors found compelling empirical evidence of scientists relying on in-silico approaches to develop novel drugs and drug delivery systems for treating glaucoma. This review in nanoscale drug delivery systems will help us in understand the existing queries and evidence gaps and will pave way for effective design of novel ocular drug delivery systems

Unique Ocular Drug Delivery Systems

2013 ◽  
pp. 73-73
Author(s):  
Xiadong Zheng ◽  
Ashim Mitra ◽  
James Hill ◽  
Marg Marquart
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery

scholarly journals Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

2015 ◽  
Vol 18 (5) ◽  
pp. 683 ◽  
Author(s):  
Andreza Maria Ribeiro ◽  
Ana Figueiras ◽  
Francisco Veiga
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Ocular Tissue ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
New Therapeutic Approaches ◽  
Ophthalmic Drug

Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Advances in ocular drug delivery systems

Eye ◽  
2020 ◽  
Vol 34 (8) ◽  
pp. 1371-1379 ◽  
Author(s):  
Jennifer J. Kang-Mieler ◽  
Kayla M. Rudeen ◽  
Wenqiang Liu ◽  
William F. Mieler
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery

Injectable,in situ forming poly(propylene fumarate)-based ocular drug delivery systems

2007 ◽  
Vol 83A (3) ◽  
pp. 656-666 ◽  
Author(s):  
H. Ueda ◽  
M.C. Hacker ◽  
A. Haesslein ◽  
S. Jo ◽  
D.M. Ammon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
In Situ Forming ◽  
Poly Propylene

scholarly journals Recent Advances in Ocular Drug Delivery Systems

Polymers ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 193-221 ◽  
Author(s):  
Noriyuki Kuno ◽  
Shinobu Fujii
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Recent Advances
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