Top-down mass spectrometry and hydrogen/deuterium exchange for comprehensive structural characterization of interferons: Implications for biosimilars

Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

Approach to Characterization of the Higher Order Structure of Disulfide-Containing Proteins Using Hydrogen/Deuterium Exchange and Top-Down Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac501789e ◽

2014 ◽

Vol 86 (15) ◽

pp. 7293-7298 ◽

Cited By ~ 16

Author(s):

Guanbo Wang ◽

Igor A. Kaltashov

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry

Journal of Visualized Experiments ◽

10.3791/62672 ◽

2021 ◽

Author(s):

Lingxiao Chaihu ◽

Xiaopeng Yao ◽

Xiang Xu ◽

Zhongqin Zhu ◽

David D. Y. Chen ◽

...

Keyword(s):

Mass Spectrometry ◽

Capillary Electrophoresis ◽

Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

Structural Characterization of Histone Octamers at Varied Salt Concentrations Using Hydrogen‐Deuterium Exchange Mass Spectrometry

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.06177 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

Adam Timmerman

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Histone Octamers

Protein Structural Characterization by Hydrogen/Deuterium Exchange Mass Spectrometry with Top-down Electron Capture Dissociation

Bulletin of the Korean Chemical Society ◽

10.5012/bkcs.2013.34.5.1401 ◽

2013 ◽

Vol 34 (5) ◽

pp. 1401-1406 ◽

Cited By ~ 3

Author(s):

Hai Dong Yu ◽

Seonghee Ahn ◽

Byungjoo Kim

Keyword(s):

Mass Spectrometry ◽

Electron Capture ◽

Electron Capture Dissociation ◽

Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Structural characterization of methionine and leucine enkephalins by hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.1739 ◽

2004 ◽

Vol 19 (1) ◽

pp. 1-8 ◽

Cited By ~ 25

Author(s):

Xianmei Cai ◽

Chhabil Dass

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Electrospray Ionization ◽

Deuterium Exchange ◽

Tandem Mass ◽

Ionization Tandem Mass Spectrometry

Hydrogen Deuterium ◽

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

ACS Chemical Biology ◽

10.1021/acschembio.1c00376 ◽

2021 ◽

Author(s):

Scott J. Eron ◽

Hongwei Huang ◽

Roman V. Agafonov ◽

Mark E. Fitzgerald ◽

Joe Patel ◽

...

Keyword(s):

Mass Spectrometry ◽

Computational Modeling ◽

Ternary Complexes ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Structural Characterization of Impurities and Degradation Products in Pharmaceuticals Using High-Resolution LC-MS and Online Hydrogen/Deuterium Exchange Mass Spectrometry

Characterization of Impurities and Degradants Using Mass Spectrometry ◽

10.1002/9780470921371.ch5 ◽

2011 ◽

pp. 135-181

Author(s):

Guodong Chen ◽

Birendra N. Pramanik

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

Degradation Products ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)

ChemBioChem ◽

10.1002/cbic.200890061 ◽

2008 ◽

Vol 9 (16) ◽

pp. 2549-2549

Author(s):

Michael B. Tropak ◽

Gregory J. Kornhaber ◽

Brigitte A. Rigat ◽

Gustavo H. Maegawa ◽

Justin D. Buttner ◽

...

Keyword(s):

Mass Spectrometry ◽

Gaucher Disease ◽

Deuterium Exchange ◽

Pharmacological Chaperones ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Picture Identification

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac802575y ◽

2009 ◽

Vol 81 (7) ◽

pp. 2644-2651 ◽

Cited By ~ 137

Author(s):

Damian Houde ◽

Joseph Arndt ◽

Wayne Domeier ◽

Steven Berkowitz ◽

John R. Engen

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Comparative higher-order structure analysis of antibody biosimilars using combined bottom-up and top-down hydrogen-deuterium exchange mass spectrometry

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2016.08.013 ◽

2016 ◽

Vol 1864 (12) ◽

pp. 1801-1808 ◽

Cited By ~ 19

Author(s):

Jingxi Pan ◽

Suping Zhang ◽

Christoph H. Borchers

Keyword(s):

Mass Spectrometry ◽

Structure Analysis ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Top Down ◽

Hydrogen Deuterium ◽