Bone turnover in asthmatic children treated with oral prednisolone or inhaled budesonide

1993 ◽  
Vol 16 (6) ◽  
pp. 341-346 ◽  
Author(s):  
Ole D. Wolthers ◽  
Bente Juel Riis ◽  
Søsren Pedersen
Keyword(s):  
Bone Turnover ◽  
Oral Prednisolone ◽  
Asthmatic Children ◽  
Inhaled Budesonide

Endocrine effects of inhaled budesonide compared with inhaled fluticasone propionate and oral prednisolone in healthy Beagle dogs

2012 ◽  
Vol 194 (3) ◽  
pp. 349-353 ◽  
Author(s):  
Marika Melamies ◽  
Outi Vainio ◽  
Thomas Spillmann ◽  
Jouni Junnila ◽  
Minna M. Rajamäki
Keyword(s):  
Fluticasone Propionate ◽  
Oral Prednisolone ◽  
Beagle Dogs ◽  
Endocrine Effects ◽  
Inhaled Budesonide

scholarly journals Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation

2017 ◽  
Vol 120 (3) ◽  
pp. 303-311 ◽  
Author(s):  
Yang Quan‐Jun ◽  
Zhang Jian‐Ping ◽  
Zhang Jian‐Hua ◽  
Han Yong‐Long ◽  
Xin Bo ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Metabolic Profile ◽  
Asthmatic Children ◽  
Inhaled Budesonide

scholarly journals Inhaled budesonide versus oral prednisolone in the treatment of acute exacerbation of moderate bronchial asthma: an open label randomized clinical trial

2021 ◽  
Vol 9 (4) ◽  
pp. 1138
Author(s):  
Reashma Roshan ◽  
Mubashir H. Shah ◽  
Aejaz A. Bhat
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Acute Exacerbation ◽  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Oral Prednisolone ◽  
Open Label ◽  
Oxygen Inhalation ◽  
Group B ◽  
Inhaled Budesonide

Background: Recently published studies have suggested that inhaled corticosteroids may offer benefit over systemic steroids in bronchial asthma. This research was carried out to study the efficacy of inhaled budesonide and to compare the efficacy of inhaled budesonide with oral prednisolone in the treatment of acute moderate asthma in children.Methods: This was an open label randomized clinical trial. Children in the age group of 1-12 years with acute exacerbation of asthma presenting to pediatric emergency from November 1, 2015 to October 31, 2016 who fail to show prompt improvement after initial treatment with oxygenand three doses of inhaled salbutamol, were enrolled. Children in group B (n=35) and group P (n=35) received inhaled budesonide and oral prednisolone, respectively, in addition to oxygen inhalation and salbutamol as per the study protocol. Outcome was measured in terms of pulmonary score at the beginning, at 6 hours, and at 24 hours of starting the treatment. The analysis was undertaken according to intent to treat principle.Results: Baseline characteristics (sex, age, weight, height, body mass index) were comparable in the 2 groups. Mean heart rate, respiratory rate, pulmonary score at 6 and 24 hours, mean SpO2 at 24 hours were significantly showing normalizing trend (p<0.05) and mean hospital stay was significantly reduced [2.60 (±0.60) vs 3.11 (±0.80); p<0.05] in group B as compared to group P.Conclusions: Outcome measures of clinical improvement were better in inhaled budesonide group than oral prednisolone group in acute moderate exacerbation of bronchial asthma. 

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