Descriptive proteomics of paired human vocal fold and buccal mucosa tissue

Pemphigus vulgaris is an autoimmune blistering disorder that involves the skin and mucous membranes. Few reports have described nasal and oropharyngolaryngeal lesions in pemphigus vulgaris using an endoscopic ororhinolaryngologic examination. We retrospectively reviewed the clinical records of 11 patients with pemphigus vulgaris between 2001 and 2013 with respect to their symptoms, lesion sites, lesion features, and treatments received. All patients had undergone an endoscopic ororhinolaryngologic examination. Their mucosa-related symptoms were sore throat, oral pain, odynophagia, gingival bleeding, hoarseness, and epistaxis. The most frequent sites were the oral cavity (gingiva and buccal mucosa), larynx (epiglottis and vocal fold), oropharynx (soft palate), and nasal cavity (nasal septum). Lesions were typically characterized by erosion, erosion with a whitish exudate, and erythematous patches. Thus, our study findings reveal that pemphigus vulgaris involves both the nasal and oropharyngolaryngeal regions. Patients with pemphigus vulgaris should undergo an endoscopic ororhinolaryngologic examination to determine the range of their lesions.

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Use of a Buccal Mucosa Graft for Bilateral Ejinell’s Laterofixation of the Vocal Fold to Successfully Treat Posterior Glottic Stenosis

Koutou (THE LARYNX JAPAN) ◽

10.5426/larynx.32.184 ◽

2020 ◽

Vol 32 (02) ◽

pp. 184-188

Author(s):

Yosuke Nakanishi ◽

Tomokazu Yoshizaki

Keyword(s):

Buccal Mucosa ◽

Vocal Fold ◽

Buccal Mucosa Graft

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Vocal Function following Vertical Hemilaryngectomy: Comparison of Four Reconstruction Techniques in the Canine

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949710600401 ◽

1997 ◽

Vol 106 (4) ◽

pp. 261-270 ◽

Cited By ~ 13

Author(s):

Robert J. Andrews ◽

Thomas C. Calcaterra ◽

Joel A. Sercarz ◽

Jody Kreiman ◽

Ming Ye ◽

...

Keyword(s):

Layered Structure ◽

Buccal Mucosa ◽

Vocal Fold ◽

Muscle Flap ◽

Canine Model ◽

Autologous Tissue ◽

Vocal Function ◽

Mucosal Flap ◽

Endoscopic Findings

The goals of laryngeal reconstruction have been prevention of aspiration, production of a functional voice, and maintenance of an adequate airway for decannulation. A number of procedures for partial laryngeal reconstruction have accomplished these objectives. However, few studies have attempted to compare patients' vocal characteristics following different reconstruction procedures. In this study, an in vivo canine model was used to compare acoustic and aerodynamic measures of vocal function for the following vertical hemilaryngectomy reconstruction techniques: 1) a superiorly based sternohyoid muscle flap, 2) a modified epiglottic laryngoplasty, 3) a new procedure using a layered vascularized buccal mucosal flap and a transversely oriented sternohyoid muscle flap, and 4) hemilaryngeal transplantation combined with arytenoid adduction. Hemitransplantation provided the most efficient phonation of the four techniques. The vascularized buccal mucosa flap produced the best phonation of the autologous tissue techniques examined. Both vascularized buccal mucosa flap and hemilaryngeal transplantation subjects demonstrated a mucosal wave on stroboscopy. The results indicate that vocal function will improve as the layered structure of the vocal fold is more accurately replicated in a reconstructed hemilarynx. Endoscopic findings and whole organ sections are presented.

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Assessment of Tongue Position and Laryngeal Height in Two Professional Voice Populations

Journal of Speech Language and Hearing Research ◽

10.1044/2019_jslhr-19-00164 ◽

2020 ◽

Vol 63 (1) ◽

pp. 109-124

Author(s):

Carly Jo Hosbach-Cannon ◽

Soren Y. Lowell ◽

Raymond H. Colton ◽

Richard T. Kelley ◽

Xue Bao

Keyword(s):

Vocal Fold ◽

Vocal Tract ◽

Current Knowledge ◽

Acoustic Resonance ◽

Contact Dynamics ◽

Voice Disorder ◽

Music Program ◽

Tongue Position ◽

Singer Groups ◽

Professional Voice

Purpose To advance our current knowledge of singer physiology by using ultrasonography in combination with acoustic measures to compare physiological differences between musical theater (MT) and opera (OP) singers under controlled phonation conditions. Primary objectives addressed in this study were (a) to determine if differences in hyolaryngeal and vocal fold contact dynamics occur between two professional voice populations (MT and OP) during singing tasks and (b) to determine if differences occur between MT and OP singers in oral configuration and associated acoustic resonance during singing tasks. Method Twenty-one singers (10 MT and 11 OP) were included. All participants were currently enrolled in a music program. Experimental procedures consisted of sustained phonation on the vowels /i/ and /ɑ/ during both a low-pitch task and a high-pitch task. Measures of hyolaryngeal elevation, tongue height, and tongue advancement were assessed using ultrasonography. Vocal fold contact dynamics were measured using electroglottography. Simultaneous acoustic recordings were obtained during all ultrasonography procedures for analysis of the first two formant frequencies. Results Significant oral configuration differences, reflected by measures of tongue height and tongue advancement, were seen between groups. Measures of acoustic resonance also showed significant differences between groups during specific tasks. Both singer groups significantly raised their hyoid position when singing high-pitched vowels, but hyoid elevation was not statistically different between groups. Likewise, vocal fold contact dynamics did not significantly differentiate the two singer groups. Conclusions These findings suggest that, under controlled phonation conditions, MT singers alter their oral configuration and achieve differing resultant formants as compared with OP singers. Because singers are at a high risk of developing a voice disorder, understanding how these two groups of singers adjust their vocal tract configuration during their specific singing genre may help to identify risky vocal behavior and provide a basis for prevention of voice disorders.

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Update: Behavioral Management of Unilateral Vocal Fold Paralysis and Paresis

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2019_pers-sig3-2018-0018 ◽

2019 ◽

Vol 4 (3) ◽

pp. 474-482

Author(s):

Sarah L. Schneider

Keyword(s):

Vocal Fold ◽

Treatment Plan ◽

Traumatic Injury ◽

Voice Therapy ◽

Valuable Insight ◽

Behavioral Management ◽

Use Patterns ◽

Vocal Quality ◽

And Function ◽

Voice Use

PurposeVocal fold motion impairment (VFMI) can be the result of iatrogenic or traumatic injury or may be idiopathic in nature. It can result in glottic incompetence leading to changes in vocal quality and ease. Associated voice complaints may include breathiness, roughness, diplophonia, reduced vocal intensity, feeling out of breath with talking, and vocal fatigue with voice use. A comprehensive interprofessional voice evaluation includes auditory-perceptual voice evaluation, laryngeal examination including videostroboscopy, acoustic and aerodynamic voice measures. These components provide valuable insight into laryngeal structure and function and individual voice use patterns and, in conjunction with stimulability testing, help identify candidacy for voice therapy and choice of therapeutic techniques.ConclusionA comprehensive, interprofessional evaluation of patients with VFMI is necessary to assess the role of voice therapy and develop a treatment plan. Although there is no efficacy data to support specific voice therapy techniques for treating VFMI, considerations for various techniques are provided.

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Acoustic Changes in Chinese Patients With Cancer-Related Unilateral Vocal Fold Paralysis After Medialization Thyroplasty

Contemporary Issues in Communication Science and Disorders ◽

10.1044/cicsd_35_s_17 ◽

2008 ◽

Vol 35 (Spring) ◽

pp. 17-24 ◽

Cited By ~ 4

Author(s):

Manwa L. Ng ◽

Ripley K. Wong ◽

William I. Wei ◽

Y. H. Wong ◽

Paul K. Y. Lam

Keyword(s):

Vocal Fold ◽

Vocal Fold Paralysis ◽

Chinese Patients ◽

Unilateral Vocal Fold Paralysis ◽

Patients With Cancer ◽

Medialization Thyroplasty

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Pediatric Benign Vocal Fold Lesions: A Team Approach

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd19.3.105 ◽

2009 ◽

Vol 19 (3) ◽

pp. 105-112 ◽

Cited By ~ 3

Author(s):

Geralyn Harvey Woodnorth ◽

Roger C. Nuss

Keyword(s):

Vocal Fold ◽

Evaluation Process ◽

Team Approach ◽

Speech Language Pathologist ◽

Benign Vocal Fold Lesions ◽

Different Types ◽

Team Evaluation ◽

Surgical Treatments ◽

Review Current ◽

Vocal Fold Nodules

Abstract Many children with dysphonia present with benign vocal fold lesions, including bilateral vocal fold nodules, cysts, vocal fold varices, and scarring. Evaluation and treatment of these children are best undertaken in a thoughtful and coordinated manner involving both the speech-language pathologist and the otolaryngologist. The goals of this article are (a) to describe the team evaluation process based on a “whole system” approach; (b) to discuss etiological factors and diagnosis; and (c) to review current medical, behavioral, and surgical treatments for children with different types of dysphonia.

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