Connecting the Dots: Multistage Fracturing in Horizontal Wells with Multilayered Reservoirs - Lessons Learned

Efficient multistage hydraulic fracturing in horizontal wells in tight-gas formations with multilayered and laminated reservoirs is a very challenging subject matter; due to formation structure, required well trajectory, and the ability to establish a conductive and permanent connection between all the layers. BP Oman had initiated the technical journey to deliver an effective horizontal well multistage frac design through learnings obtained during three key pilot horizontal wells. Since these initial wells, additional candidates have been drilled and stimulated, resulting in further advancement of the learning curve. Many aspects will be covered in this paper, that will describe how to facilitate the most effective hydraulic fracture placement and production performance, under these laminated conditions. These approaches will include the completion and perforation selection, fracture initiation zone selection, fracture height consideration, frac fluid type and design. The paper will go on to describe a range of different surveillance options, including clean-up and performance surveillance as well as number of other factors. The experiences that have been gained provide valuable insight and learning about how to approach a multistage fracturing horizontal well program in this kind of depositional environment. Additionally, how these lessons can potentially be subsequently adapted and applied to access resources in the more challenging and higher risk areas of the field. For example, this paper will present direct comparison of over and under-displaced stages; differences in execution and production for cased hole and open hole completions; and many other variables that always under discussion for hydraulic fracturing in horizontal wells. This paper describes in detail the results of many multistage fracturing trials by BP Oman in horizontal wells drilled in challenging multilayered and laminated tight-gas reservoirs. These findings may help to cut short learning curve in similar reservoirs in the Middle East Region and elsewhere.

Real-World Prescribing Pattern of Asthma Management in China: A Retrospective, Descriptive Analysis

Background Asthma is a chronic inflammatory disorder of the airway that requires long-term medication management. Objective To describe the real-world prescribing patterns for asthma management in the Chinese population. Methods A retrospective analysis of 8,732 patients from January 2011 to September 2019 in 10 hospitals was conducted. Prescribing patterns of short-acting beta-agonists (SABA), long-acting beta-agonists (LABA), inhaled corticosteroids (ICS), intravenous corticosteroids, antihistamines, leukotriene receptor antagonists (LTRA), theophylline, antibiotics, and Chinese patent medicines were included in the analysis. Chi-square and logistic regression were calculated. P value of <0.05 was considered as statistical significance. Results ICS/LABA were prescribed for 2,940 (33.67%) patients with stable asthma and 141 (31.4%) patients with asthma exacerbations. LTRA was prescribed in 2,006 (22.97%) patients with stable asthma, and 86 (19.15%) patients with asthma exacerbations. Systemic antibiotics (46.1Z%), systemic corticosteroids (57.91%), and theophylline (51.45%) were frequently prescribed during exacerbations. A total of 5,766 patients (64.95%) were managed with traditional Chinese medication (TCM); 3237 patients (36.47%) received western medicine. Patients using ICS/LABA (P=0.019) and SABA (P=0.008) had a significantly lower rate of asthma exacerbations. Conclusions This study provides valuable insight into clinical practices of asthma management in China. Poor adherence to clinical reports was identified. Efforts are required to improve the quality of asthma care.

Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles

The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs’ elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.

Healthcare professionals' experience of performing digital care visits - a scoping review

Background: The use of patient initiated digital care visits has been increasing and even more so in the era of the Coronavirus (COVID-19) pandemic. Learning more about healthcare professionals’ experience of using such technology would provide valuable insight and a basis for improvement of digital visits.Aim: This study sought to explore the existing literature on healthcare professionals’ experience of performing digital care visits.Methods: A scoping review was performed following Arksey & O’Malley’s proposed framework and utilizing the Preferred Reporting Items for Systematic reviews and Meta-Analyses – Extension for Scoping Reviews (PRISMA-ScR) checklist. Three large databases – PubMed, Web of Science and IEEE Xplore were searched, and 28 studies were included in the review. The collected data was analyzed using thematic content analysis.Results: Five main themes were identified in the literature: positive experiences/benefits, facilitators, negative experiences/challenges, barriers, and suggestions for improvement. Healthcare professionals mostly reported having overall positive experience with digital visits and saw benefits for themselves and the patients – efficiency, convenience, accessibility, and new perspectives in remote care to name a few. However, opinions were mixed or negative regarding the complexity of decision making, workload and workflow, suitability of this type of care and other challenges. The suggestions for improvement included training and education, improvements within system and tools and support for professionals.Conclusion: Despite overall positive experience and benefits for both professionals and patients, clinicians reported challenges and issues they faced when using digital care visits: physical barriers, technical issues, suitability concerns and others. Digital care visits could not fully replace face-to face visits.

Abnormal disclosure tone, earnings management and earnings quality

PurposeThe authors investigate whether abnormal tone in corporate narrative disclosures is associated with earnings management and earnings quality, in an emerging market context. Based on agency theory and opportunistic/impression management perspective, this study examines whether executives manage disclosure tone to support their opportunistic behavior, when using earnings management.Design/methodology/approachThis study uses a sample of earnings press releases of publicly traded firms in the MENA region during 2014–2019. It employs textual analysis to measure disclosure tone. The authors estimate abnormal disclosure tone after controlling for firm characteristics. Discretionary accruals proxy for earnings management and are estimated using Modified Jones model. Earnings quality is measured using accounting-based and market-based proxies: earnings smoothness, persistence, predictability and value relevance/informativeness.FindingsResults show a positive association between abnormal disclosure tone and earnings management. Additionally, results show that earnings persistence is higher for firms with lower levels of abnormal disclosure tone. Results are sustained for earnings smoothness, but not for predictability and value relevance/informativeness.Research limitations/implicationsResults provide initial evidence of management's use of tone management jointly with earnings management. This adds to prior studies adopting the opportunistic perspective of disclosure tone, through showing that discretionary tone in narrative disclosures can be strategically used by management to influence investors' perceptions.Practical implicationsThe results provide valuable insight to board of directors, auditors and market participants on the possible biases emerging from tone of narrative disclosures in corporate reports. For regulators and standard-setters, results shed light on the need for regulations and rules beyond financial statements, to guide disclosure of narrative information in different corporate reports.Originality/valueThis study contributes to the rare evidence that investigates textual disclosure characteristics to uncover management's opportunistic practices and assess earnings quality. Where majority of studies concentrate on developed markets, this study provides novel evidence of emerging markets by examining the association between abnormal disclosure tone and earnings management/earnings quality. Also, it validates the tone management model proposed by Huang et al. (2014) for capturing tone manipulation.

Mass Ratio and Spot Parameter Estimation from Eclipsing Binary Star Light Curves

Eclipsing binary stars have a rich history of contributing to the field of stellar astrophysics. Most of the available information on the fundamental properties of stars has come from the analysis of observations of binaries. The availability of powerful computers and sophisticated codes that apply physical models has resulted in determinations of masses and radii of sufficient accuracy to provide critical tests of theories of stellar structure and evolution. Despite their sophistication, these codes still require the guiding hand of trained scientists to extract reliable information. The computer code will produce results, but it is still imperative for the analyst to ensure that those results make astrophysical sense, and to ascertain their reliability. Care must be taken to ensure that we are asking the codes for parameters for which there is information in the data. The analysis of synthetic observations with simulated observational errors of typical size can provide valuable insight to the analysis process because the parameters used to generate the observations are known. Such observations are herein analyzed to guide the process of determining mass ratios and spot parameters from eclipsing binary light curves. The goal of this paper is to illustrate some of the subtleties that need to be recognized and treated properly when analyzing binary star data.

Establishing the Relative Importance of Specific Sustainability Themes That Influence Women’s Choice of Engineering as a Career Using the Analytical Hierarchy Process

Understanding the importance of salient factors associated with sustainability challenges that engineers are known to solve in influencing women’s choice of engineering is particularly important in this present world where a combination of these sustainability issues, the underrepresentation of women and the need for more engineers remain a challenge to the profession. However, little is known about the degree of importance of more detailed themes within the social, environmental and economic sustainability pillars in such career decisions. Consequently, the aim of this paper is to understand the relative importance of specific sustainability-themed factors influencing women’s choice of engineering, using the Analytical Hierarchy Process (AHP). An AHP structurally designed online survey was used to gather and analyze data from a sample of 414 UK and Nigeria respondents. The results showed that of all the ten sustainability-themed factors examined in this study, water quality/quantity, climate change, waste management, biodiversity, and material consumption/energy use, had a greater influence on the respondents’ choice of engineering relative to other factors. The data revealed specific rather than general sustainability themes that appeal to women’s choice of engineering. This could offer valuable insight from a recruitment strategy perspective to help engineering stakeholders to focus their attention and recruitment efforts on the most salient areas of influence.

Collaboration between clinical and academic laboratories for sequencing SARS-CoV-2 genomes

Genomic sequencing of SARS-CoV-2 continues to provide valuable insight into the ever-changing variant makeup of the COVID-19 pandemic. More than three million SARS-COV-2 genomes have been deposited in GISAID, but contributions from the United States, particularly through 2020, lagged behind the global effort. The primary goal of clinical microbiology laboratories is seldom rooted in epidemiologic or public health testing and many labs do not contain in-house sequencing technology. However, we recognized the need for clinical microbiologists to lend expertise, share specimen resources, and partner with academic laboratories and sequencing cores to assist in SARS-COV-2 epidemiologic sequencing efforts. Here we describe two clinical and academic laboratory collaborations for SARS-COV-2 genomic sequencing. We highlight roles of the clinical microbiologists and the academic labs, outline best practices, describe two divergent strategies in accomplishing a similar goal, and discuss the challenges with implementing and maintaining such programs.

CXCR4 Mediates Enhanced Cell Migration in CALM-AF10 Leukemia

Leukemia transformed by the CALM-AF10 chromosomal translocation is characterized by a high incidence of extramedullary disease, central nervous system (CNS) relapse, and a poor prognosis. Invasion of the extramedullary compartment and CNS requires leukemia cell migration out of the marrow and adherence to the cells of the local tissue. Cell adhesion and migration are increasingly recognized as contributors to leukemia development and therapeutic response. These processes are mediated by a variety of cytokines, chemokines, and their receptors, forming networks of both secreted and cell surface factors. The cytokines and cytokine receptors that play key roles in CALM-AF10 driven leukemia are unknown. We find high cell surface expression of the cytokine receptor CXCR4 on leukemia cells expressing the CALM-AF10 oncogenic protein, contributing to the migratory nature of this leukemia. Our discovery of altered cytokine receptor expression and function provides valuable insight into the propagation and persistence of CALM-AF10 driven leukemia.

Electromagnetic Form Factors of Σ Hyperons

Electromagnetic form factors (EMFFs) are fundamental observable of baryons that intimately related to their internal structure and dynamics, where the EMFFs of hyperons provide valuable insight into the behavior of the strangeness. The EMFFs of hyperons can also help to understand those of nucleons as they are connected with the flavor SU(3) symmetry. The EMFFs of nucleons can be measured in both spacelike and timelike regions. However, it is difficult to probe the EMFFs of hyperons in spacelike region due to the unstable nature of hyperons. By means of electron-positron annihilation, the EMFFs of hyperons in timelike region is accessible via the production of hyperon-antihyperon pair. The timelike EMFFs of the isospin triplet Σ hyperons measured at Babar, CLEO-c and BESIII experiments are reviewed in this paper. Besides, the relevant theoretical discussion based on the experimental results are also presented.