scholarly journals Correlation between methylation of the caveolin‐1 gene and of caveolin‐1 messenger ribonucleic acid, and protein levels and human epidermal growth factor receptor 2 protein expression in adenocarcinomas of the esophagogastric junction

2019 ◽  
Vol 3 (1) ◽  
pp. 8-14
Author(s):  
Ruizhen Liu ◽  
Yi Kong ◽  
Pengbo Sun ◽  
Faliang Li ◽  
Xiaopeng Shi
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Ribonucleic Acid ◽  
Esophagogastric Junction ◽  
Growth Factor Receptor ◽  
Messenger Ribonucleic Acid ◽  
Caveolin 1 ◽  
Protein Levels ◽  
Epidermal Growth

scholarly journals Estrogen Regulation of Epidermal Growth Factor Receptor Messenger Ribonucleic Acid

1988 ◽  
Vol 2 (3) ◽  
pp. 230-235 ◽  
Author(s):  
Russell B. Lingham ◽  
George M. Stancel ◽  
David S. Loose-Mitchell
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Ribonucleic Acid ◽  
Growth Factor Receptor ◽  
Estrogen Regulation ◽  
Messenger Ribonucleic Acid ◽  
Epidermal Growth

scholarly journals Integrin α1β1 Regulates Epidermal Growth Factor Receptor Activation by Controlling Peroxisome Proliferator-Activated Receptor γ-Dependent Caveolin-1 Expression

2010 ◽  
Vol 30 (12) ◽  
pp. 3048-3058 ◽  
Author(s):  
Xiwu Chen ◽  
Carrie Whiting ◽  
Corina Borza ◽  
Wen Hu ◽  
Stacey Mont ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Peroxisome Proliferator ◽  
Ros Production ◽  
Peroxisome Proliferator Activated Receptor ◽  
Caveolin 1 ◽  
Egfr Activation ◽  
Epidermal Growth

ABSTRACT Integrin α1β1 negatively regulates the generation of profibrotic reactive oxygen species (ROS) by inhibiting epidermal growth factor receptor (EGFR) activation; however, the mechanism by which it does this is unknown. In this study, we show that caveolin-1 (Cav-1), a scaffolding protein that binds integrins and controls growth factor receptor signaling, participates in integrin α1β1-mediated EGFR activation. Integrin α1-null mesangial cells (MCs) have reduced Cav-1 levels, and reexpression of the integrin α1 subunit increases Cav-1 levels, decreases EGFR activation, and reduces ROS production. Downregulation of Cav-1 in wild-type MCs increases EGFR phosphorylation and ROS synthesis, while overexpression of Cav-1 in the integrin α1-null MCs decreases EGFR-mediated ROS production. We further show that integrin α1-null MCs have increased levels of activated extracellular signal-regulated kinase (ERK), which leads to reduced activation of peroxisome proliferator-activated receptor γ (PPARγ), a transcription factor that positively regulates Cav-1 expression. Moreover, activation of PPARγ or inhibition of ERK increases Cav-1 levels in the integrin α1-null MCs. Finally, we show that glomeruli of integrin α1-null mice have reduced levels of Cav-1 and activated PPARγ but increased levels of phosphorylated EGFR both at baseline and following injury. Thus, integrin α1β1 negatively regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARγ axis plays a key role in regulating integrin α1β1-dependent Cav-1 expression and consequent EGFR-mediated ROS production.

scholarly journals Suppression of Epidermal Growth Factor Receptor Signaling by Protein Kinase C-α Activation Requires CD82, Caveolin-1, and Ganglioside

2007 ◽  
Vol 67 (20) ◽  
pp. 9986-9995 ◽  
Author(s):  
Xiao-qi Wang ◽  
Qiu Yan ◽  
Ping Sun ◽  
Ji-Wei Liu ◽  
Linda Go ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Protein Kinase C ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Caveolin 1 ◽  
Kinase C ◽  
Epidermal Growth ◽  
Growth Factor Receptor Signaling

Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer

Lung Cancer ◽  
2005 ◽  
Vol 48 (1) ◽  
pp. 47-57 ◽  
Author(s):  
C.M. Richardson ◽  
D. Richardson ◽  
D.E.B. Swinson ◽  
W.A. Swain ◽  
G. Cox ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Receptor Expression ◽  
Small Cell Lung ◽  
Protein Levels ◽  
Epidermal Growth

scholarly journals Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II

2011 ◽  
Vol 50 (3) ◽  
pp. 545-551 ◽  
Author(s):  
Akira Takaguri ◽  
Heigoro Shirai ◽  
Keita Kimura ◽  
Akinari Hinoki ◽  
Kunie Eguchi ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Angiotensin Ii ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Caveolin 1 ◽  
Epidermal Growth ◽  
Receptor Transactivation
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