scholarly journals A generalized knowledge-based discriminatory function for biomolecular interactions

2009 ◽  
Vol 76 (1) ◽  
pp. 115-128 ◽  
Author(s):  
Brady Bernard ◽  
Ram Samudrala
Author(s):  
CHAN-JIN CHUNG ◽  
ROBERT G. REYNOLDS

Self-adaptation has been frequently employed in evolutionary computation. Angeline1 defined three distinct adaptive levels which are: population, individual and component levels. Cultural Algorithms have been shown to provide a framework in which to model self-adaptation at each of these levels. Here, we examine the role that different forms of knowledge can play in the self-adaptation process at the population level for evolution-based function optimizers. In particular, we compare the relative performance of normative and situational knowledge in guiding the search process. An acceptance function using a fuzzy inference engine is employed to select acceptable individuals for forming the generalized knowledge in the belief space. Evolutionary programming is used to implement the population space. The results suggest that the use of a cultural framework can produce substantial performance improvements in execution time and accuracy for a given set of function minimization problems over population-only evolutionary systems.


Author(s):  
Mona Simion

This chapter is up to an ambitious task: it develops the first integrated account of the epistemic normativity of constatives. In order to do that, it argues for a generalized knowledge-based account of the epistemic normativity of constative speech, and it develops the corresponding accounts for, respectively, assertives, predictives, retrodictives, descriptives, ascriptives, informatives, confirmatives, concessives, retractives, assentives, dissentives, disputatives, responsives, suggestives, and suppositives. The chapter argues for a knowledge account from three different angles: (1) the nature of communicative speech acts, (2) the relation between assertion and other constatives, and (3) the normativity of belief together with constatives’ epistemic function.


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