Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II

1993 ◽  
Vol 17 (1) ◽  
pp. 93-106 ◽  
Author(s):  
Yafeng Xue ◽  
Anders Liljas ◽  
Bengt-Harald Jonsson ◽  
Sven Lindskog
Keyword(s):  
Hydrogen Bond ◽  
Structural Analysis ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Ii ◽  
Zinc Hydroxide ◽  
Hydrogen Bond Network ◽  
Bond Network ◽  
Human Carbonic Anhydrase

Effect of the hydrogen bond network in carbonic anhydrase II zinc binding site. A theoretical study

1998 ◽  
Vol 76 (7) ◽  
pp. 1027-1032 ◽  
Author(s):  
Silvia Álvarez-Santos ◽  
Àngels González-Lafont ◽  
José M Lluch
Keyword(s):  
Hydrogen Bond ◽  
Carbonic Anhydrase ◽  
Binding Site ◽  
Zinc Binding ◽  
Carbonic Anhydrase Ii ◽  
Am1 Method ◽  
Hydrogen Bond Network ◽  
Zinc Binding Site ◽  
Bond Network ◽  
Metal Ligand

The hydrogen bond network influence on the carbonic anhydrase II (CAII) zinc binding site has been studied theoretically by using the semiempirical AM1 method. To this aim, quantum mechanical reduced models of wild-type CAII and several CAII variants have been constructed. We have shown that, when a direct metal ligand donates a hydrogen bond to an indirect metal ligand, the first-shell residues enhance their electrostatic interaction with the zinc cation. Thus, the hydrogen-bond network is able to modulate the zinc binding affinity and the zinc-water pKa.Key words: hydrogen bond network, carbonic anhydrase II, Zn2+ metalloenzyme ligands.

scholarly journals Structural analysis of human carbonic anhydrase II and a thermophillic intein (768.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Daniel Haley ◽  
Nicolle Siegart ◽  
Julie Reitter ◽  
Kenneth Mills
Keyword(s):  
Structural Analysis ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Ii ◽  
Human Carbonic Anhydrase

scholarly journals Structural analysis of inhibitor binding to human carbonic anhydrase II

1998 ◽  
Vol 7 (12) ◽  
pp. 2483-2489 ◽  
Author(s):  
P. Ann Boriack-Sjodin ◽  
Samantha Zeitlin ◽  
David W. Christianson ◽  
Huang-Hsing Chen ◽  
Lori Crenshaw ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Ii ◽  
Inhibitor Binding ◽  
Human Carbonic Anhydrase

scholarly journals A Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II

Biochemistry ◽  
2010 ◽  
Vol 49 (2) ◽  
pp. 249-251 ◽  
Author(s):  
Balendu Sankara Avvaru ◽  
Chae Un Kim ◽  
Katherine H. Sippel ◽  
Sol M. Gruner ◽  
Mavis Agbandje-McKenna ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Carbonic Anhydrase ◽  
Active Site ◽  
Carbonic Anhydrase Ii ◽  
Strong Hydrogen Bond ◽  
Human Carbonic Anhydrase

NMR Studies of Active-Site Properties of Human Carbonic Anhydrase II by Using15N-Labeled 4-Methylimidazole as a Local Probe and Histidine Hydrogen-Bond Correlations

2014 ◽  
Vol 21 (7) ◽  
pp. 2915-2929 ◽  
Author(s):  
Ilya G. Shenderovich ◽  
Stepan B. Lesnichin ◽  
Chingkuang Tu ◽  
David N. Silverman ◽  
Peter M. Tolstoy ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Carbonic Anhydrase ◽  
Active Site ◽  
Carbonic Anhydrase Ii ◽  
Nmr Studies ◽  
Human Carbonic Anhydrase
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