Essential oil of Chinese medicinal herb,Blumea balsamiferaleaves, was found to possess fumigant toxicity against the maize weevils,Sitophilus zeamais. The main components of the essential oil ofB. balsamiferawere 1,8-cineole (20.98%), borneol (11.99%),β-caryophyllene (10.38%), camphor (8.06%), 4-terpineol (6.49%),α-terpineol (5.91%), and caryophyllene oxide (5.35%). Bioactivity-guided chromatographic separation of the essential oil on repeated silica gel columns led to isolate five constituent compounds, namely, 1,8-cineole, borneol, camphor,α-terpineol, and 4-terpineol. 1,8-Cineole, 4-terpineol, andα-terpineol showed pronounced fumigant toxicity againstS. zeamaisadults (LC50= 2.96 mg/L, 4.79 mg/L, and 7.45 mg/L air, resp.) and were more toxic than camphor (LC50= 21.64 mg/L air) and borneol (LC50= 21.67 mg/L air). The crude essential oil also possessed strong fumigant toxicity againstS. zeamaisadults (LC50= 10.71 mg/L air).