Mismatch repair deficiency increases the transfer of antibiosis and antixenosis properties against Colorado potato beetle in somatic hybrids ofSolanum tuberosum+S. chacoense

2016 ◽  
Vol 73 (7) ◽  
pp. 1428-1437 ◽  
Author(s):  
Imola Molnár ◽  
Enikő Besenyei ◽  
Ramona Thieme ◽  
Thomas Thieme ◽  
Adriana Aurori ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Colorado Potato Beetle ◽  
Somatic Hybrids ◽  
Mismatch Repair Deficiency ◽  
Potato Beetle ◽  
Repair Deficiency

scholarly journals Drought and Saline Stress Tolerance Induced in Somatic Hybrids of Solanum chacoense and Potato Cultivars by Using Mismatch Repair Deficiency

Agriculture ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 696
Author(s):  
Imola Molnár ◽  
Lavinia Cozma ◽  
Tünde-Éva Dénes ◽  
Imre Vass ◽  
István-Zoltán Vass ◽  
...  
Keyword(s):  
Climate Change ◽  
Mismatch Repair ◽  
Crop Production ◽  
Somatic Hybrids ◽  
Potato Cultivars ◽  
Solanum Chacoense ◽  
Saline Stress ◽  
Severe Drought ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

Global climate change, especially when involving drought and salinity, poses a major challenge to sustainable crop production, causing severe yield losses. The environmental conditions are expected to further aggravate crop production in the future as a result of continuous greenhouse gas emissions, causing further temperature rise and leading to increased evapotranspiration, severe drought, soil salinity, as well as insect and disease threats. These suboptimal growth conditions have negative impact on plant growth, survival, and crop yield. Potato is well known as a crop extremely susceptible to drought, which is primarily attributed to its shallow root system. With potato being the fourth major food crop, increasing potato productivity is thus important for food security and for feeding global population. To maintain a sustainable potato production, it is necessary to develop stress tolerant potato cultivars that cope with the already ongoing climate change. The aim of our study is to analyze the response of potato somatic hybrids to drought and salt stress under in vitro conditions; the somatic hybrids studied are the wild relative Solanum chacoense (+) Solanum tuberosum, with or without mismatch repair deficiency (MMR). Upon this selection of drought and salt tolerant genotypes, somatic hybrids and their parents were phenotyped on a semi-automated platform, and lines tolerant to medium water scarcity (20% compared to 60% soil water capacity) were identified. Although none of the parental species were tolerant to drought, some of the MMR-deficient somatic hybrids showed tolerance to drought and salt as a new trait.

Low Frequency of Mismatch Repair Deficiency in a Large Cohort of Non-liver fluke associated Cholangiocarcinomas

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
B Goeppert ◽  
S Roessler ◽  
M Renner ◽  
S Singer ◽  
A Mehrabi ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Liver Fluke ◽  
Low Frequency ◽  
Large Cohort ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse

Nature Cancer ◽  
2021 ◽  
Author(s):  
Fan Yang ◽  
Samuel W. Brady ◽  
Chao Tang ◽  
Huiying Sun ◽  
Lijuan Du ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

scholarly journals RARE-55. CHALLENGES AND SPECIFIC STRATEGIES FOR CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY SYNDROME IN LOW RESOURCE SETTINGS. ON BEHALF OF THE INTERNATIONAL RRD CONSORTIUM IN LOW RESOURCE SETTINGS PANEL

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii454-iii454
Author(s):  
Rejin Kebudi ◽  
Nisreen Amayiri N ◽  
Malak Abedalthagafi ◽  
Asim Noor Rana ◽  
Slman Kirmani ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Checkpoint Inhibitors ◽  
Immune Therapy ◽  
Malignant Gliomas ◽  
Mismatch Repair Deficiency ◽  
Term Survival ◽  
Low Resource Settings ◽  
Low Resource ◽  
Repair Deficiency ◽  
Constitutional Mismatch Repair Deficiency

Abstract Germline biallelic mutations in one of the mismatch repair genes (MSH2/MSH6/MLH1/PMS2 results in constitutional mismatch repair deficiency (CMMRD), a condition associated with multiple tumors arising from multiple organs during childhood, and these individuals rarely reach adulthood. The paucity of information with respect to these conditions leads to mismanagement and may be a factor in the high mortality of patients with CMMRD. Two international consortia, the European CARE4CMMRD, and the international replication repair deficiency (RRD) consortium, are addressing the many challenges associated with this condition. To address specific issues surrounding the management of CMMRD in low and middle income countries (LMIC), a multidisciplinary taskforce of 11 specialists from nine countries was formed. Preliminary conclusions are: 1) Immunohistochemistry for CMMRD should be considered for all patients with suggestive clinical features. In countries where CMMRD is common, malignant gliomas, colon cancers and T cell lymphomas should be stained routinely as the prevalence of CMMRD in these tumors can exceed 40%. 2) Temozolomide should not be used in the management of malignant glioma. By contrast, preclinical studies have suggested increased sensitivity to nitrosoureas. For the management of CMMRD related lymphoma and leukemia, mercaptopurines should not be avoided or discontinued as a part of the standard of care before more data are collected. 3) Management with checkpoint inhibitors should be limited to centers with intensive care units and expertise in complex supportive care to manage side effects of immune therapy. 4) Surveillance protocols have demonstrated long term survival benefits and should be implemented in LMIC.

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