A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12461 ◽

2019 ◽

Vol 8 (10) ◽

pp. 738-747 ◽

Author(s):

Hannah M. Jones ◽

Zhiwei Zhang ◽

Paul Jasper ◽

Haobin Luo ◽

Lindsay B. Avery ◽

...

Keyword(s):

Monoclonal Antibody ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Antibody Pharmacokinetics ◽

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Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

Pharmaceutical Research ◽

10.1007/s11095-014-1333-3 ◽

2014 ◽

Vol 31 (9) ◽

pp. 2367-2382 ◽

Author(s):

Michael Gertz ◽

Nikolaos Tsamandouras ◽

Carolina Säll ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction ◽

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Use of In Vitro Data for Construction of a Physiologically Based Pharmacokinetic Model for Naphthalene in Rats and Mice To Probe Species Differences

Biotechnology Progress ◽

10.1021/bp990057t ◽

1999 ◽

Vol 15 (3) ◽

pp. 540-555 ◽

Author(s):

D.J. Quick ◽

M.L. Shuler

Keyword(s):

Pharmacokinetic Model ◽

Species Differences ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Rats And Mice ◽

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Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study

10.1016/j.tox.2014.05.006 ◽

2015 ◽

Vol 332 ◽

pp. 52-66 ◽

Author(s):

Miyoung Yoon ◽

Gregory L. Kedderis ◽

Grace Zhixia Yan ◽

Harvey J. Clewell

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

Toxicological Sciences ◽

10.1093/toxsci/kfz042 ◽

2019 ◽

Vol 169 (2) ◽

pp. 365-379 ◽

Author(s):

Gina Song ◽

Marjory Moreau ◽

Alina Efremenko ◽

Brian G Lake ◽

Huali Wu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic ◽

Age Related ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12547 ◽

2020 ◽

Vol 9 (9) ◽

pp. 534-541

Author(s):

Hannah M. Jones ◽

John Tolsma ◽

Zhiwei Zhang ◽

Paul Jasper ◽

Haobin Luo ◽

...

Keyword(s):

Monoclonal Antibody ◽

Half Life ◽

Pharmacokinetic Model ◽

Life Extension ◽

Physiologically Based Pharmacokinetic Model ◽

Catch And Release ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Antibody Pharmacokinetics

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A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model

mAbs ◽

10.1080/19420862.2020.1813962 ◽

2020 ◽

Vol 12 (1) ◽

pp. 1813962

Author(s):

Songmao Zheng ◽

Jin Niu ◽

Brian Geist ◽

Damien Fink ◽

Zhenhua Xu ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Monoclonal Antibody ◽

Bowel Disease ◽

Treatment Effects ◽

Pharmacokinetic Model ◽

Disease Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Inflammatory Bowel

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The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.04.002 ◽

2020 ◽

Vol 109 (7) ◽

pp. 2345-2355

Author(s):

Kei Mayumi ◽

Miho Tachibana ◽

Mei Yoshida ◽

Shuichi Ohnishi ◽

Takushi Kanazu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

The Novel ◽

Physiologically Based Pharmacokinetic Model ◽

In Vitro Method ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based ◽

High Predictability ◽

Plasma Partition Coefficient

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Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050294 ◽

2013 ◽

Vol 41 (4) ◽

pp. 744-753 ◽

Author(s):

Katherine L. Gill ◽

Michael Gertz ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Evaluation of an integrated in vitro–in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2005.11.002 ◽

2006 ◽

Vol 308 (1-2) ◽

pp. 133-139 ◽

Author(s):

Hongliang Cai ◽

Chad Stoner ◽

Anita Reddy ◽

Sascha Freiwald ◽

Danielle Smith ◽

...

Keyword(s):

In Silico ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independently in Vitro and in Vivo

Toxicological Sciences ◽

10.1093/toxsci/32.2.260 ◽

1996 ◽

Vol 32 (2) ◽

pp. 260-268

Author(s):

JOOST DEJONGH ◽

BAS J. BLAAUBOER

Keyword(s):

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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