A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12547 ◽

2020 ◽

Vol 9 (9) ◽

pp. 534-541

Author(s):

Hannah M. Jones ◽

John Tolsma ◽

Zhiwei Zhang ◽

Paul Jasper ◽

Haobin Luo ◽

...

Keyword(s):

Monoclonal Antibody ◽

Half Life ◽

Pharmacokinetic Model ◽

Life Extension ◽

Physiologically Based Pharmacokinetic Model ◽

Catch And Release ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Antibody Pharmacokinetics

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12461 ◽

2019 ◽

Vol 8 (10) ◽

pp. 738-747 ◽

Author(s):

Hannah M. Jones ◽

Zhiwei Zhang ◽

Paul Jasper ◽

Haobin Luo ◽

Lindsay B. Avery ◽

...

Keyword(s):

Monoclonal Antibody ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Antibody Pharmacokinetics ◽

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A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model

mAbs ◽

10.1080/19420862.2020.1813962 ◽

2020 ◽

Vol 12 (1) ◽

pp. 1813962

Author(s):

Songmao Zheng ◽

Jin Niu ◽

Brian Geist ◽

Damien Fink ◽

Zhenhua Xu ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Monoclonal Antibody ◽

Bowel Disease ◽

Treatment Effects ◽

Pharmacokinetic Model ◽

Disease Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Inflammatory Bowel

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Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-014-9374-0 ◽

2014 ◽

Vol 41 (6) ◽

pp. 571-580 ◽

Author(s):

Yanguang Cao ◽

William J. Jusko

Keyword(s):

Monoclonal Antibody ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.117.244855 ◽

2018 ◽

Vol 365 (1) ◽

pp. 140-155 ◽

Author(s):

Xi Chen ◽

Xiling Jiang ◽

Rajitha Doddareddy ◽

Brian Geist ◽

Thomas McIntosh ◽

...

Keyword(s):

Monoclonal Antibody ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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A minimal physiologically based pharmacokinetic model to investigate FcRn-mediated monoclonal antibody salvage: Effects of Kon, Koff, endosome trafficking, and animal species

mAbs ◽

10.1080/19420862.2018.1506648 ◽

2018 ◽

Vol 10 (8) ◽

pp. 1322-1331 ◽

Author(s):

Brian M. Maas ◽

Yanguang Cao

Keyword(s):

Monoclonal Antibody ◽

Animal Species ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Endosome Trafficking ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

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Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime

Environmental Research ◽

10.1016/j.envres.2021.111287 ◽

2021 ◽

pp. 111287

Author(s):

Deepika Deepika ◽

Raju Prasad Sharma ◽

Marta Schuhmacher ◽

Vikas Kumar

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Perfluorooctane Sulfonate ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate

Archives of Toxicology ◽

10.1007/s00204-021-03057-5 ◽

2021 ◽

Author(s):

Seung-Hyun Jeong ◽

Ji-Hun Jang ◽

Hea-Young Cho ◽

Yong-Bok Lee

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Major Metabolite ◽

Physiologically Based Pharmacokinetic Model ◽

Human Risk Assessment ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically‐Based Pharmacokinetic Model for Alectinib, Ruxolitinib, and Panobinostat in The Presence of Cancer, Renal Impairment, and Hepatic Impairment

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2282 ◽

2021 ◽

Author(s):

Mo'tasem M. Alsmadi

Keyword(s):

Renal Impairment ◽

Hepatic Impairment ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a Physiologically-Based Pharmacokinetic Model for Perchloroethylene Using Tissue Concentration-Time Data

Toxicology and Applied Pharmacology ◽

10.1006/taap.1994.1179 ◽

1994 ◽

Vol 128 (1) ◽

pp. 50-59 ◽

Author(s):

C.E. Dallas ◽

X.M. Chen ◽

K. Obarr ◽

S. Muralidhara ◽

P. Varkonyi ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Tissue Concentration ◽

Physiologically Based Pharmacokinetic Model ◽

Time Data ◽

Physiologically Based Pharmacokinetic ◽

Concentration Time ◽

Physiologically Based

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