Apigenin enhances viability of random skin flaps by activating autophagy

Introduction: Perianal hidradenitis suppurativa is a chronic recurrent inflammatory, suppurative, and fistulising disease of apocrine glands, adjacent anal canal and soft tissues. Perianal area is the second most common affected area after axilla. There are three grades of the disease. Hidradenitis suppurativa represents a chronic, recurrent, deep-seated folliculitis resulting in abscesses, followed by the formation of sinus tracts and subsequent scarring. Perianal hidradenitis suppurativa is the last and the most serious grade of the disease and a specific access is needed for patient preparation and surgical treatment alone. The currently preferred method of treatment for patients with extensive perianal hidradentitis is excision and closure with combination of skin flaps, primary suture and skin graft in one or two stages. Case reports: There are three case reports of perianal hidradenitis suppurativa in this article. The local and overall initial treatment of patients followed by a radical excision and closure with a rotation skin flaps and skin grafts is described. The final results were satisfactory, with no recurrence or serious complication.

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Preclinical efficacy of stem cell therapy for skin flap: a systematic review and meta-analysis

Stem Cell Research & Therapy ◽

10.1186/s13287-020-02103-w ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Yuan Li ◽

Qi-lin Jiang ◽

Leanne Van der Merwe ◽

Dong-hao Lou ◽

Cai Lin

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Stem Cell ◽

Survival Rate ◽

Meta Analysis ◽

Skin Flap ◽

Cochrane Library ◽

Skin Flaps ◽

Cell Based Therapy ◽

Stem Cell Treatment

Abstract Background A skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the skin flap severely restricts the clinical application of flap surgery. As there is no consensus on the treatment methods to prevent distal necrosis of skin flaps, more effective and feasible interventions to prevent skin flaps from necrosis are urgently needed. Stem therapy as a potential method to improve the survival rate of skin flaps is receiving increasing attention. Methods This review followed the recommendations from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statements. Twenty studies with 500 animals were included by searching Web of Science, EMBASE, PubMed, and Cochrane Library databases, up until October 8, 2020. Moreover, the references of the included articles were searched manually to obtain other studies. All analyses were conducted using Review Manager V.5.3 software. Results Meta-analysis of all 20 studies demonstrated stem cell treatment has significant effects on reducing necrosis of skin flap compared with the control group (SMD: 3.20, 95% CI 2.47 to 3.93). Besides, subgroup analysis showed differences in the efficacy of stem cells in improving the survival rate of skin flaps in areas of skin flap, cell type, transplant types, and method of administration of stem cells. The meta-analysis also showed that stem cell treatment had a significant effect on increasing blood vessel density (SMD: 2.96, 95% CI 2.21 to 3.72) and increasing the expression of vascular endothelial growth factor (VEGF, SMD: 4.34, 95% CI 2.48 to 6.1). Conclusions The preclinical evidence of our systematic review indicate that stem cell-based therapy is effective for promoting early angiogenesis by up regulating VEGF and ultimately improving the survival rate of skin flap. In summary, small area skin flap, the administration method of intra-arterial injection, ASCs and MSCs, and xenogenic stem cells from humans showed more effective for the survival of animal skin flaps. In general, stem cell-based therapy may be a promising method to prevent skin flap necrosis.

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Local Skin Flaps on the Cheeks

The Journal of Dermatologic Surgery and Oncology ◽

10.1111/j.1524-4725.1991.tb01609.x ◽

1991 ◽

Vol 17 (2) ◽

pp. 161-165 ◽

Cited By ~ 18

Author(s):

RICHARD G. BENNETT

Keyword(s):

Skin Flaps ◽

Local Skin

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Histological changes in intra-oral skin flaps

Head & Neck Oncology ◽

10.1186/1758-3284-1-2 ◽

2009 ◽

Vol 1 (1) ◽

Cited By ~ 14

Author(s):

Julia Anne Woolgar ◽

Asterios Triantafyllou

Keyword(s):

Skin Flaps ◽

Histological Changes

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How we do it: A novel approach to the skin?abutment interface of the bone-anchored hearing aid: use of local skin flaps

Clinical Otolaryngology ◽

10.1111/j.1365-2273.2006.01264.x ◽

2006 ◽

Vol 31 (6) ◽

pp. 540-542 ◽

Cited By ~ 8

Author(s):

R.A.P. Persaud ◽

N. Papadimitriou ◽

T. Siva ◽

P. Kothari ◽

J.S. Quinn

Keyword(s):

Hearing Aid ◽

Skin Flaps ◽

Local Skin ◽

Hearing Aid Use ◽

Novel Approach ◽

Bone Anchored Hearing Aid

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Comparative analysis of tissue fluorescence as related to capillary perfusion in random pattern skin flaps

British Journal of Plastic Surgery ◽

10.1016/0007-1226(92)90023-q ◽

1992 ◽

Vol 45 (8) ◽

pp. 578-585 ◽

Cited By ~ 10

Author(s):

Thomas J. Galla ◽

Ingrun Anton-Lamprecht ◽

Meinhard Kieser ◽

Rainer K. Saetzler ◽

Konrad Messmer

Keyword(s):

Comparative Analysis ◽

Random Pattern ◽

Skin Flaps ◽

Capillary Perfusion ◽

Tissue Fluorescence

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TOWARD AN ANATOMICAL AND HEMODYNAMIC CLASSIFICATION OF SKIN FLAPS

Plastic & Reconstructive Surgery ◽

10.1097/00006534-197509000-00014 ◽

1975 ◽

Vol 56 (3) ◽

pp. 330-331 ◽

Cited By ~ 3

Author(s):

Rollin K. Daniel

Keyword(s):

Skin Flaps

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