Improved detection of host cell proteins (HCPs) in a mammalian cell-derived antibody drug using liquid chromatography/mass spectrometry in conjunction with an HCP-enrichment strategy

Host Cell Proteins ◽

Enrichment Strategy ◽

Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry

mAbs ◽

10.4161/mabs.4.1.18748 ◽

2012 ◽

Vol 4 (1) ◽

pp. 24-44 ◽

Cited By ~ 108

Author(s):

Catalin Doneanu ◽

Alex Xenopoulos ◽

Keith Fadgen ◽

Jim Murphy ◽

St. John Skilton ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Host Cell ◽

Two Dimensional ◽

Host Cell Proteins ◽

ACS Symposium Series - State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 3. Defining the Next Generation of Analytical and Biophysical Techniques ◽

Improved Identification and Quantification of Host Cell Proteins (HCPs) in Biotherapeutics Using Liquid Chromatography-Mass Spectrometry

10.1021/bk-2015-1202.ch013 ◽

2015 ◽

pp. 357-393 ◽

Cited By ~ 1

Author(s):

Weibin Chen ◽

Catalin E. Doneanu ◽

Matthew Lauber ◽

Stephan Koza ◽

Kesh Prakash ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Host Cell ◽

Host Cell Proteins ◽

Identification And Quantification

A rapid approach for characterization of thiol-conjugated antibody–drug conjugates and calculation of drug–antibody ratio by liquid chromatography mass spectrometry

Analytical Biochemistry ◽

10.1016/j.ab.2015.06.001 ◽

2015 ◽

Vol 485 ◽

pp. 34-42 ◽

Cited By ~ 30

Author(s):

David Firth ◽

Leonard Bell ◽

Martin Squires ◽

Sian Estdale ◽

Colin McKee

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Drug Antibody Ratio ◽

Antibody Ratio ◽

Streamlined Characterization of an Antibody–Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.9b02454 ◽

2019 ◽

Vol 91 (23) ◽

pp. 14896-14903 ◽

Cited By ~ 11

Author(s):

Alexandre Goyon ◽

Michael Kim ◽

Lu Dai ◽

Christopher Cornell ◽

Fred Jacobson ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Two Dimensional ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Measurement of in Vivo Drug Load Distribution of Cysteine-Linked Antibody–Drug Conjugates Using Microscale Liquid Chromatography Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac403860c ◽

2014 ◽

Vol 86 (7) ◽

pp. 3420-3425 ◽

Cited By ~ 55

Author(s):

Shawna Mae Hengel ◽

Russell Sanderson ◽

John Valliere-Douglass ◽

Nicole Nicholas ◽

Chris Leiske ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Load Distribution ◽

Drug Load ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Fast sampling method for mammalian cell metabolic analyses using liquid chromatography–mass spectrometry

Nature Protocols ◽

10.1038/nprot.2014.198 ◽

2014 ◽

Vol 10 (1) ◽

pp. 1-11 ◽

Cited By ~ 41

Author(s):

Giuseppe Martano ◽

Nathanaël Delmotte ◽

Patrick Kiefer ◽

Philipp Christen ◽

David Kentner ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Mammalian Cell ◽

Sampling Method ◽

Quantitation of Sphingolipids in Mammalian Cell Lines by Liquid Chromatography–Mass Spectrometry

Springer Protocols Handbooks - Analysis of Membrane Lipids ◽

10.1007/978-1-0716-0631-5_7 ◽

2020 ◽

pp. 103-117

Author(s):

Nihal Medatwal ◽

Ujjaini Dasgupta

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Cell Lines ◽

Mammalian Cell ◽

Mammalian Cell Lines ◽

Liquid Chromatography/Mass Spectrometry, MS/MS and Time of Flight MS

10.1021/bk-2003-0850 ◽

2003 ◽

Cited By ~ 14

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Time Of Flight ◽

Advances in the Use of Liquid Chromatography Mass Spectrometry (LC-MS) - Instrumentation Developments and Applications

10.1016/s0166-526x(17)x0006-8 ◽

2018 ◽

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Separation and identification of peptides by integrated multidimensional liquid chromatography-mass spectrometry (IMDLC-MS)

10.32469/10355/6028 ◽

2007 ◽

Author(s):

Harika Adusumilli

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽