Measurement of in Vivo Drug Load Distribution of Cysteine-Linked Antibody–Drug Conjugates Using Microscale Liquid Chromatography Mass Spectrometry

Drug Load ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

A rapid approach for characterization of thiol-conjugated antibody–drug conjugates and calculation of drug–antibody ratio by liquid chromatography mass spectrometry

Analytical Biochemistry ◽

10.1016/j.ab.2015.06.001 ◽

2015 ◽

Vol 485 ◽

pp. 34-42 ◽

Cited By ~ 30

Author(s):

David Firth ◽

Leonard Bell ◽

Martin Squires ◽

Sian Estdale ◽

Colin McKee

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Drug Antibody Ratio ◽

Antibody Ratio ◽

Structural elucidation of in vivo metabolites of penehyclidine in rats by the method of liquid chromatography–mass spectrometry, gas chromatography–mass spectrometry and isotope ion cluster

Journal of Chromatography B ◽

10.1016/j.jchromb.2008.07.049 ◽

2008 ◽

Vol 873 (1) ◽

pp. 41-50 ◽

Cited By ~ 7

Author(s):

Ying Liu ◽

Mingming Wang ◽

Ming Xue ◽

Yuhang Li ◽

Xiaorong Li ◽

...

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Liquid Chromatography ◽

Structural Elucidation ◽

Gas Chromatography Mass Spectrometry ◽

Ion Cluster

In Vivo Neurochemical Monitoring Using Benzoyl Chloride Derivatization and Liquid Chromatography–Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac202794q ◽

2011 ◽

Vol 84 (1) ◽

pp. 412-419 ◽

Cited By ~ 153

Author(s):

Peng Song ◽

Omar S. Mabrouk ◽

Neil D. Hershey ◽

Robert T. Kennedy

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Benzoyl Chloride ◽

Carboxylesterase and UDP-glucuronosyltransferases mediated metabolism of irinotecan: In vitro and in vivo insights from quantitative ultra-performance liquid chromatography-mass spectrometry analysis

Biomedical Chromatography ◽

10.1002/bmc.4320 ◽

2018 ◽

Vol 32 (10) ◽

pp. e4320 ◽

Cited By ~ 1

Author(s):

Yifeng Qin ◽

An Kang ◽

Guisheng Zhou ◽

Huan Wang ◽

Wei Wei ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Ultra Performance Liquid Chromatography ◽

Mass Spectrometry Analysis ◽

Spectrometry Analysis ◽

Determination of methylphenidate in Calliphorid larvae by liquid–liquid extraction and liquid chromatography mass spectrometry – Forensic entomotoxicology using an in vivo rat brain model

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2012.06.024 ◽

2012 ◽

Vol 70 ◽

pp. 456-461 ◽

Cited By ~ 8

Author(s):

Sarah K. Bushby ◽

Nicky Thomas ◽

Petra A. Priemel ◽

Carolyn V. Coulter ◽

Thomas Rades ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Rat Brain ◽

Liquid Extraction ◽

Liquid Liquid Extraction ◽

Metabolites characterization of timosaponin AIII in vivo and in vitro by using liquid chromatography-mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2015.06.015 ◽

2015 ◽

Vol 997 ◽

pp. 236-243 ◽

Cited By ~ 10

Author(s):

Yu Sun ◽

Liyin Liu ◽

Ying Peng ◽

Bingjie Liu ◽

Dongju Lin ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Timosaponin Aiii

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Analytical Biochemistry ◽

10.1016/j.ab.2011.01.004 ◽

2011 ◽

Vol 412 (1) ◽

pp. 56-66 ◽

Cited By ~ 143

Author(s):

Keyang Xu ◽

Luna Liu ◽

Ola M. Saad ◽

Jakub Baudys ◽

Lara Williams ◽

...

Keyword(s):

Mass Spectrometry ◽

Capillary Liquid Chromatography ◽

Affinity Capture ◽

Drug Conjugates ◽

Intact Antibody ◽

Capillary Liquid ◽

Exploring in vivo violacein biosynthesis by application of multivariate curve resolution on fused UV–VIS absorption, fluorescence, and liquid chromatography–mass spectrometry data

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-012-6507-4 ◽

2012 ◽

Vol 405 (4) ◽

pp. 1293-1302 ◽

Cited By ~ 8

Author(s):

Clecio Dantas ◽

Romà Tauler ◽

Márcia Miguel Castro Ferreira

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Mass Spectrometry Data ◽

Multivariate Curve Resolution ◽

Curve Resolution ◽

Streamlined Characterization of an Antibody–Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.9b02454 ◽

2019 ◽

Vol 91 (23) ◽

pp. 14896-14903 ◽

Cited By ~ 11

Author(s):

Alexandre Goyon ◽

Michael Kim ◽

Lu Dai ◽

Christopher Cornell ◽

Fred Jacobson ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Two Dimensional ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2010.02.008 ◽

2010 ◽

Vol 52 (5) ◽

pp. 687-693 ◽

Cited By ~ 14

Author(s):

Jian-Zhong Chen ◽

Gui-Xin Chou ◽

Chang-Hong Wang ◽

Li Yang ◽

S.W. Annie Bligh ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Nmr Spectroscopy ◽

New Metabolites