Stable isotope dilution method for the determination of guanidinoacetic acid by gas chromatography/mass spectrometry

2003 ◽  
Vol 17 (7) ◽  
pp. 717-722 ◽  
Author(s):  
Ralph Fingerhut
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Stable Isotope ◽  
Isotope Dilution ◽  
Gas Chromatography Mass Spectrometry ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Stable Isotope Dilution ◽  
Chromatography Mass Spectrometry

Measurement of blood volume with an enriched stable isotope of chromium (53Cr) and isotope dilution by combined gas chromatography-mass spectrometry

1994 ◽  
Vol 40 (1) ◽  
pp. 71-73 ◽  
Author(s):  
C Veillon ◽  
K Y Patterson ◽  
D A Nagey ◽  
A M Tehan
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Stable Isotope ◽  
Blood Volume ◽  
Isotope Dilution ◽  
Gas Chromatography Mass Spectrometry ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Chromatography Mass Spectrometry ◽  
Survival Studies

Abstract We used an established isotope dilution gas chromatography-mass spectrometry method to measure blood volumes with an enriched stable isotope of chromium. The results were compared with those of the conventional method, which involves radioactive 51Cr. The two methods were compared simultaneously in two male subjects of different sizes, and essentially identical volumes were obtained. The isotope dilution method is insensitive to contamination with natural (unenriched) chromium and can be used to measure all of the stable isotopes of chromium. The method has potential applications in simultaneous erythrocyte survival studies. The absence of radioactivity makes possible an accurate means of studying blood volume changes in children and during pregnancy.

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