scholarly journals Predicting pregnancy outcomes using longitudinal information: a penalized splines mixed-effects model approach

2017 ◽  
Vol 36 (13) ◽  
pp. 2120-2134 ◽  
Author(s):  
Rolando De la Cruz ◽  
Claudio Fuentes ◽  
Cristian Meza ◽  
Dae-Jin Lee ◽  
Ana Arribas-Gil
2020 ◽  
Vol 15 ◽  
Author(s):  
Shangyuan Ye ◽  
Ye Liang ◽  
Bo Zhang

Objective: As a result of the development of microarray technologies, gene expression levels of thousands of genes involved in a given biological process can be measured simultaneously, and it is important to study their temporal behavior to understand their mechanisms. Since the dependence between gene expression levels over time for a given gene is often too complicated to model parametrically, sparse functional data analysis has received an increasing amount of attention for analyzing such data. Methods: We propose a new functional mixed-effects model for analyzing time-course gene expression data. Specifically, the model groups individual functions with heterogeneous smoothness. The proposed method utilizes the mixed-effects model representation of penalized splines for both the mean function and the individual functions. Given noninformative or weakly informative priors, Bayesian inference on the proposed models was developed, and Bayesian computation was implemented by using Markov chain Monte Carlo methods. Results: The performance of our new model was studied by two simulation studies and illustrated using a yeast cell cycle gene expression dataset. Simulation results suggest that our proposed methods can outperform the previously used methods in terms of the mean integrated squared error. The yeast gene expression data application suggests that the proposed model with two latent groups should be used on this dataset.


2011 ◽  
Vol 31 (11-12) ◽  
pp. 1190-1202 ◽  
Author(s):  
Roula Tsonaka ◽  
Annette H. M. van der Helm-van Mil ◽  
Jeanine J. Houwing-Duistermaat

2010 ◽  
Vol 29 (27) ◽  
pp. 2857-2868 ◽  
Author(s):  
Janet A. Tooze ◽  
Victor Kipnis ◽  
Dennis W. Buckman ◽  
Raymond J. Carroll ◽  
Laurence S. Freedman ◽  
...  

2018 ◽  
Vol 61 (3) ◽  
pp. 600-615 ◽  
Author(s):  
Josu Najera‐Zuloaga ◽  
Dae‐Jin Lee ◽  
Inmaculada Arostegui

Forests ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 975 ◽  
Author(s):  
Karol Bronisz ◽  
Michał Zasada

Diameter measurements along the stem, which are the basis for taper models, usually have a hierarchical structure. Mixed-effects models, where fixed and random effects are distinguished, are a possible solution for this type of data. However, in order to fully absorb the potential of this method, random effects prediction, which requires additional measurements (diameter along stem), is recommended. This article presents a comparison of various fitting methods (mixed- and fixed-effects model approaches) of the variable-exponent taper model created by Kozak for determining the outside bark diameter along the stem and predicting the tree volume of Scots pine trees in west Poland. During the analysis, it was assumed that no additional measured data were available for practical use; therefore, for the mixed-effects model approach, fixed effects prediction without random effects was applied. Both fitting strategies were compared based on modeling and an independent validation data set. The comparison of mixed- and fixed-effects fitting strategies for the diameter along the stem indicated that the taper model fitted using the mixed-effects model approach better fit the data. Moreover, the error rate for the total tree volume prediction for the independent data set was lower for the mixed-effects model solution than for the fixed-effects one.


2017 ◽  
Vol 20 (9) ◽  
pp. A739
Author(s):  
JW Geenen ◽  
SV Belitser ◽  
RA Vreman ◽  
O Klungel ◽  
JA Raaijmakers ◽  
...  

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