scholarly journals Preclinical assessment of dual CYP26[A1/B1] inhibitor, DX308, as an improved treatment for keratinization disorders

2021 ◽  
Author(s):  
J.G.S. Veit ◽  
Y. Poumay ◽  
D. Mendes ◽  
J. Kreitinger ◽  
L. Walker ◽  
...  
Keyword(s):  
Keratinization Disorders

scholarly journals Ichthyoses—A Clinical and Pathological Spectrum from Heterogeneous Cornification Disorders to Inflammation

2021 ◽  
Vol 8 (2) ◽  
pp. 107-123
Author(s):  
Dieter Metze ◽  
Heiko Traupe ◽  
Kira Süßmuth
Keyword(s):  
Stratum Granulosum ◽  
Internal Organs ◽  
Histopathologic Diagnosis ◽  
Epidermolytic Ichthyosis ◽  
Life Threatening ◽  
Keratinization Disorders ◽  
Gene Defects ◽  
Immunohistochemical Methods

Ichthyoses are inborn keratinization disorders affecting the skin only (non-syndromic) or are associated with diseases of internal organs (syndromic). In newborns, they can be life-threatening. The identification of the gene defects resulted in reclassification and a better understanding of the pathophysiology. Histopathologic patterns include orthohyperkeratosis with a reduced or well-developed stratum granulosum, hyperkeratosis with ortho- and parakeratosis with preserved or prominent stratum granulosum, and epidermolytic ichthyosis. Another pattern features “perinuclear vacuoles and binucleated keratinocytes”, which is associated with keratin mutations. Some ichthyoses are histologically defined by psoriasis-like features, and distinct subtypes show follicular hyperkeratosis. In addition to histological and immunohistochemical methods, these patterns allow a better histopathologic diagnosis.

Dermatology

2020 ◽  
pp. 559-616
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Nazia Hussain ◽  
Emma Nash ◽  
...  
Keyword(s):  
General Practice ◽  
Skin Cancer ◽  
Fungal Infection ◽  
Sweat Gland ◽  
Skin Infection ◽  
Skin Tumours ◽  
Nail Changes ◽  
Skin Erythema ◽  
Keratinization Disorders ◽  
Skin Conditions

This chapter in the Oxford Handbook of General Practice explores dermatology in general practice. It covers skin assessment, treatment of skin conditions, changes in skin colour and eruptions, itching and blistering of the skin, erythema, pigmentation disorder, hair and sweat gland problems, nail changes, and atopic and other eczemas. It discusses ulcers, urticaria, angio-oedema, acne, psoriasis, lichen planus, keratinization disorders, pityriasis, and seborrhoeic warts. It examines sunlight and the skin, benign skin tumours, and skin cancer. It also explores bacterial skin infection, viral skin infection, fungal infection, and infestation.

scholarly journals Inherited Keratinization Disorders

TURKDERM ◽  
2011 ◽  
Vol 45 (2) ◽  
pp. 73-80
Author(s):  
Ayşen Karaduman
Keyword(s):  
Keratinization Disorders

scholarly journals Molecular Genetics of Keratinization Disorders – What’s New About Ichthyosis

2020 ◽  
Vol 100 (7) ◽  
pp. adv00095-185 ◽  
Author(s):  
J Uitto ◽  
L Youssefian ◽  
A Saeidian ◽  
H Vahidnezhad
Keyword(s):  
Molecular Genetics ◽  
Keratinization Disorders

scholarly journals Characterization of CYP26B1-Selective Inhibitor, DX314, as a Potential Therapeutic for Keratinization Disorders

2021 ◽  
Vol 141 (1) ◽  
pp. 72-83.e6 ◽  
Author(s):  
Joachim G.S. Veit ◽  
Valérie De Glas ◽  
Benoît Balau ◽  
Haoming Liu ◽  
Florence Bourlond ◽  
...  
Keyword(s):  
Selective Inhibitor ◽  
Keratinization Disorders
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