Fetal Medicine Foundation fetal and neonatal population weight charts

Abstract Purpose Despite the rise of non-invasive screening tests for fetal aneuploidy, invasive testing during pregnancy remains the definitive diagnostic tool for fetal genetic anomalies. Results are rapidly available with polymerase chain reaction (PCR) tests, but cases have been reported whereby initial results were not confirmed after pregnancy termination and the fetal karyotype was ultimately normal. We sought to examine the potential discordance between PCR and karyotype for fetal aneuploidy. Methods The results from all amniocentesis and CVS tests performed over a 6-year period in a large tertiary level fetal medicine unit were reviewed. The results of PCR and karyotype were recorded and discrepancies examined. Pregnancy outcomes were also recorded. Results A total of 1222 invasive tests were performed (716 amniocentesis and 506 CVS). Within the cohort having amniocentesis, 11 had discrepant results (normal QF-PCR result but with a subsequent abnormal karyotype). There was 1 case among this group which QF-PCR should have identified. Within the CVS group, 7 patients had discrepant results. All had a diploid QF-PCR and would not have been identified as abnormal by it. Conclusion PCR can be reliably used to determine aneuploidy of chromosomes 13, 18, and 21. However, in cases of sex chromosome aneuploidy, its performance is less reliable and warrants waiting for a complete karyotype. Given such discordance, we advise waiting for karyotype for all invasive tests performed in the presence of a normal ultrasound before advising a patient of a diploid QF-PCR result or potentially terminating a normal pregnancy.

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Safety and efficacy evaluation of the automatic stepwise recruitment manoeuvre in the neonatal population: An in‐vivo interventional study

Pediatric Anesthesia ◽

10.1111/pan.14243 ◽

2021 ◽

Author(s):

Clara Serrano Zueras ◽

Verónica Guilló Moreno ◽

Martín Santos González ◽

Francisco Javier Gómez Nieto ◽

Göran Hedenstierna ◽

...

Keyword(s):

Recruitment Manoeuvre ◽

Interventional Study ◽

Efficacy Evaluation ◽

Safety And Efficacy ◽

Neonatal Population

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855. Significance of Invasive Infections due to Methicillin Sensitive Staphylococcus aureus in the neonatal population

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.1044 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S468-S468

Author(s):

Mariawy Riollano ◽

Deena Altman ◽

shanna kowalsky ◽

Stephanie Pan

Keyword(s):

Staphylococcus Aureus ◽

Clinical Characteristics ◽

Invasive Disease ◽

Control Measures ◽

Invasive Infection ◽

Single Center ◽

Infection Control Measures ◽

Invasive Infections ◽

Mrsa Colonization ◽

Neonatal Population

Abstract Background Staphylococcus aureus is a well-known cause of hospital acquired infections. Methicillin resistant staphylococcus aureus (MRSA) colonization is a recognized risk factor for invasive infections. The neonatal population in the intensive care unit (NICU) is particularly vulnerable to these types of infections, resulting in high mortality and morbidity. However, only scant data is available to establish the risk for invasive disease in patients with Methicillin sensitive staphylococcus aureus (MSSA). As a result, surveillance and prevention strategies are only address for MRSA colonization. Here, we describe the clinical characteristics of S. aureus colonized patients identified in late 2018 during transmission events in a single center NICU. As a result of the targeted surveillance investigation for MRSA infection control measures, S. aureus colonization was stratified, and we were able to compare the differences in invasive disease between MRSA and MSSA. Methods This is a retrospective chart review of the 47 colonized patients identified during October 2018- January 2019 SA transmission events in single center NICU. Risk factors, clinical characteristics, and the hospital course of these cases, including the proportion of invasive illness were reviewed. Results We found that most clinical characteristic, risk factors, and hospital course were the same between MRSA and MSSA colonized infants (p values > 0.05). Additionally, there was no difference in the proportion of invasive infection between MRSA and MSSA colonized patients (p value > 0.05). The type of invasive infections identified were SSTI, bacteremia, and osteomyelitis. Conclusion The proportion of invasive infection was the same in MSSA and MRSA colonized patients. This data provides us with supportive material for future recommendations of infection control measures for MSSA colonized patients. Disclosures All Authors: No reported disclosures

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