scholarly journals Neurodevelopmental outcome of children with spina bifida aperta repaired prenatally vs postnatally: systematic review and meta-analysis

2019 ◽  
Vol 53 (3) ◽  
pp. 293-301 ◽  
Author(s):  
A. Inversetti ◽  
L. Van der Veeken ◽  
D. Thompson ◽  
K. Jansen ◽  
F. Van Calenbergh ◽  
...  
Author(s):  
Zehra S Hepp ◽  
Verena M Haas ◽  
Beatrice Latal ◽  
Martin Meuli ◽  
Ueli Möhrlen ◽  
...  

2020 ◽  
Vol 55 (6) ◽  
pp. 730-739 ◽  
Author(s):  
L. Joyeux ◽  
F. De Bie ◽  
E. Danzer ◽  
F. M. Russo ◽  
A. Javaux ◽  
...  

2019 ◽  
Vol 74 (8) ◽  
pp. 449-451 ◽  
Author(s):  
A. Inversetti ◽  
L. Van der Veeken ◽  
D. Thompson ◽  
K. Jansen ◽  
F. Van Calenbergh ◽  
...  

2015 ◽  
Vol 109 ◽  
pp. 155-162 ◽  
Author(s):  
Elysa Widjaja ◽  
Cristina Go ◽  
Blathnaid McCoy ◽  
O. Carter Snead

2016 ◽  
Vol 36 (11) ◽  
pp. 991-996 ◽  
Author(s):  
Giuseppe M. Maruotti ◽  
Gabriele Saccone ◽  
Francesco D'Antonio ◽  
Vincenzo Berghella ◽  
Laura Sarno ◽  
...  

Neonatology ◽  
2012 ◽  
Vol 102 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Ola Didrik Saugstad ◽  
Maximo Vento ◽  
Siddarth Ramji ◽  
Diantha Howard ◽  
Roger F. Soll

Author(s):  
Roos Vliegenthart ◽  
Martijn Miedema ◽  
Gerard J Hutten ◽  
Anton H van Kaam ◽  
Wes Onland

BackgroundPlacebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI).ObjectiveTo identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages.MethodsA systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies. Studies comparing caffeine to placebo or theophylline only were excluded. Primary outcomes were BPD and mortality at 36 weeks postmenstrual age. Secondary key-outcome was neurodevelopmental outcome at 12 and 24 months corrected age. Meta-analysis was performed using RevMan 5.3.ResultsSix RCTs including 620 infants were identified. Meta-analysis showed a significant decrease in BPD, the combined outcome BPD or mortality, and failure to extubate in infants allocated to a higher caffeine dose. No differences were found in mortality alone and NDI. The quality of the outcome measures were deemed low to very low according to the Grading of Recommendations Assessment, Development and Evaluation guidelines.ConclusionsAlthough this review suggests that administering a higher dose of caffeine might enhance its beneficial effect on death or BPD, firm recommendations on the optimal caffeine dose cannot be given due to the low level of evidence. A large RCT is urgently needed to confirm or refute these findings and determine the optimal dose of caffeine.


2016 ◽  
Vol 106 (1) ◽  
pp. 159-159 ◽  
Author(s):  
Callie A. M. Atta ◽  
Kirsten M. Fiest ◽  
Alexandra D. Frolkis ◽  
Nathalie Jette ◽  
Tamara Pringsheim ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document