scholarly journals OC08.02: Neurodevelopmental outcome in isolated mild ventriculomegaly: systematic review and meta-analysis

2013 ◽  
Vol 42 (s1) ◽  
pp. 16-16
Author(s):  
G. Pagani ◽  
F. Prefumo ◽  
B. Thilaganathan
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome

scholarly journals Neurodevelopmental outcome of children with spina bifida aperta repaired prenatally vs postnatally: systematic review and meta-analysis

2019 ◽  
Vol 53 (3) ◽  
pp. 293-301 ◽  
Author(s):  
A. Inversetti ◽  
L. Van der Veeken ◽  
D. Thompson ◽  
K. Jansen ◽  
F. Van Calenbergh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spina Bifida ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome ◽  
Spina Bifida Aperta

Neurodevelopmental outcome of infantile spasms: A systematic review and meta-analysis

2015 ◽  
Vol 109 ◽  
pp. 155-162 ◽  
Author(s):  
Elysa Widjaja ◽  
Cristina Go ◽  
Blathnaid McCoy ◽  
O. Carter Snead
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome ◽  
Infantile Spasms

Neurodevelopmental Outcome of Infants Resuscitated with Air or 100% Oxygen: A Systematic Review and Meta-Analysis

Neonatology ◽  
2012 ◽  
Vol 102 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Ola Didrik Saugstad ◽  
Maximo Vento ◽  
Siddarth Ramji ◽  
Diantha Howard ◽  
Roger F. Soll
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome

High versus standard dose caffeine for apnoea: a systematic review

2018 ◽  
Vol 103 (6) ◽  
pp. F523-F529 ◽  
Author(s):  
Roos Vliegenthart ◽  
Martijn Miedema ◽  
Gerard J Hutten ◽  
Anton H van Kaam ◽  
Wes Onland
Keyword(s):  
Systematic Review ◽  
Standard Dose ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome ◽  
Optimal Dose ◽  
Controlled Trials ◽  
Level Of Evidence ◽  
Assessment Development ◽  
Postmenstrual Age ◽  
Randomised Controlled

BackgroundPlacebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI).ObjectiveTo identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages.MethodsA systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies. Studies comparing caffeine to placebo or theophylline only were excluded. Primary outcomes were BPD and mortality at 36 weeks postmenstrual age. Secondary key-outcome was neurodevelopmental outcome at 12 and 24 months corrected age. Meta-analysis was performed using RevMan 5.3.ResultsSix RCTs including 620 infants were identified. Meta-analysis showed a significant decrease in BPD, the combined outcome BPD or mortality, and failure to extubate in infants allocated to a higher caffeine dose. No differences were found in mortality alone and NDI. The quality of the outcome measures were deemed low to very low according to the Grading of Recommendations Assessment, Development and Evaluation guidelines.ConclusionsAlthough this review suggests that administering a higher dose of caffeine might enhance its beneficial effect on death or BPD, firm recommendations on the optimal caffeine dose cannot be given due to the low level of evidence. A large RCT is urgently needed to confirm or refute these findings and determine the optimal dose of caffeine.

Mild Hypoxic–Ischemic Encephalopathy: Can Neurophysiological Monitoring Predict Unfavorable Neurological Outcome? A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Raffaele Falsaperla ◽  
Sarah Sciuto ◽  
Daniela Gioè ◽  
Laura Sciuto ◽  
Francesco Pisani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neurological Outcome ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neurological Involvement ◽  
Neurophysiological Monitoring ◽  
Neonatal Deaths ◽  
Ischemic Encephalopathy

Objective Hypoxic–ischemic encephalopathy (HIE) is the second cause of neonatal deaths and one of the main conditions responsible for long-term neurological disability. Contrary to past belief, children with mild HIE can also experience long-term neurological sequelae. The aim of this systematic review is to determine the predictive value of long-term neurological outcome of (electroencephalogram) EEG/amplitude-integrated electroencephalogram (aEEG) in children who complained mild HIE. Study Design From a first search on PubMed, Google Scholar, and clinicalTrials.gov databases, only five articles were considered suitable for this study review. A statistical meta-analysis with the evaluation of odds ratio was performed on three of these studies. Results No correlation was found between the characteristics of the electrical activity of the brain obtained through EEG/aEEG in infants with mild HIE and subsequent neurological involvement. Conclusion EEG/aEEG monitoring in infants with mild HIE cannot be considered a useful tool in predicting their neurodevelopmental outcome, and its use for this purpose is reported as barely reliable. Key Points

scholarly journals OP19.09: Neurodevelopmental outcome in isolated supratentorial intracranial cysts: a systematic review and meta-analysis

2014 ◽  
Vol 44 (S1) ◽  
pp. 109-110
Author(s):  
F. D'Antonio ◽  
A. Youssef ◽  
A. Khalil ◽  
A.T. Papageorghiou ◽  
G. Pilu
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome ◽  
Intracranial Cysts

scholarly journals Treatment of posthemorrhagic ventricular dilation in preterm infants: a systematic review and meta-analysis of outcomes and complications

2015 ◽  
Vol 16 (5) ◽  
pp. 545-555 ◽  
Author(s):  
Jetan H. Badhiwala ◽  
Chris J. Hong ◽  
Farshad Nassiri ◽  
Brian Y. Hong ◽  
Jay Riva-Cambrin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Premature Infants ◽  
Meta Analysis ◽  
Demographic Data ◽  
External Ventricular Drain ◽  
Neurodevelopmental Outcome ◽  
Cochrane Library ◽  
Ventricular Dilation ◽  
Eligibility Criteria ◽  
Posthemorrhagic Hydrocephalus

OBJECT The optimal clinical management of intraventricular hemorrhage (IVH) and posthemorrhagic ventricular dilation (PHVD)/posthemorrhagic hydrocephalus (PHH) in premature infants remains unclear. A common approach involves temporary treatment of hydrocephalus in these patients with a ventriculosubgaleal shunt (VSGS), ventricular access device (VAD), or external ventricular drain (EVD) until it becomes evident that the patient needs and can tolerate permanent CSF diversion (i.e., ventriculoperitoneal shunt). The present systematic review and meta-analysis aimed to provide a robust and comprehensive summary of the published literature regarding the clinical outcomes and complications of these 3 techniques as temporizing measures in the management of prematurity-related PHVD/PHH. METHODS The authors searched MEDLINE, EMBASE, CINAHL, Google Scholar, and the Cochrane Library for studies published through December 2013 on the use of VSGSs, VADs, and/or EVDs as temporizing devices for the treatment of hydrocephalus following IVH in the premature neonate. Data pertaining to patient demographic data, study methods, interventions, and outcomes were extracted from eligible articles. For each of the 3 types of temporizing device, the authors performed meta-analyses examining 6 outcomes of interest, which were rates of 1) obstruction; 2) infection; 3) arrest of hydrocephalus (i.e., permanent shunt independence); 4) mortality; 5) good neurodevelopmental outcome; and 6) revision. RESULTS Thirty-nine studies, representing 1502 patients, met eligibility criteria. All of the included articles were observational studies; 36 were retrospective and 3 were prospective designs. Nine studies (n = 295) examined VSGSs, 24 (n = 962) VADs, and 9 (n = 245) EVDs. Pooled rates of outcome for VSGS, VAD, and EVD, respectively, were 9.6%, 7.3%, and 6.8% for obstruction; 9.2%, 9.5%, and 6.7% for infection; 12.2%, 10.8%, and 47.3% for revision; 13.9%, 17.5%, and 31.8% for arrest of hydrocephalus; 12.1%, 15.3%, and 19.1% for death; and 58.7%, 50.1%, and 56.1% for good neurodevelopmental outcome. CONCLUSIONS This study provides robust estimates of outcomes for the most common temporizing treatments for IVH in premature infants. With few exceptions, the range of outcomes was similar for VSGS, VAD, and EVD.

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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