Prediction of birth weight by fetal crown–rump length and maternal serum levels of pregnancy-associated plasma protein-A in the first trimester

AbstractEvaluate the relationship between neonatal weight and pregnancy-associated plasma protein-A.Retrospective study on 2564 singleton pregnancies with healthy term neonates in three groups of women with different values of pregnancy-associated plasma protein-A who underwent the combined test during the first trimester. Non-parametric test and correlation analysis for statistical elaboration were carried out.There exists a correlation between the serum levels of pregnancy-associated plasma protein-A in the first trimester of pregnancy and neonatal weight. Values of pregnancy-associated plasma protein-A lower than the 25This study confirms the positive correlation between circulating concentrations of pregnancy-associated plasma protein-A and fetal growth. Low neonatal weight and factors that can cause this could be determined from the first trimester by measuring the concentrations of pregnancy-associated plasma protein-A in maternal serum. Even if the association between the levels of pregnancy-associated plasma protein-A and a low neonatal weight has been demonstrated, however, we have to say that the sensitivity of a such screening method for the prediction of low birth weight and perinatal complications seems to be rather low. The variations of pregnancy-associated plasma protein-A during the first trimester cannot be used as a marker of excessive fetal growth.

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Association between first-trimester maternal serum pregnancy-associated plasma protein-A and obstetric complications

Prenatal Diagnosis ◽

10.1002/pd.4141 ◽

2013 ◽

Vol 33 (9) ◽

pp. 839-847 ◽

Cited By ~ 35

Author(s):

Francesco D'Antonio ◽

Claudia Rijo ◽

Basky Thilaganathan ◽

Ranjit Akolekar ◽

Asma Khalil ◽

...

Keyword(s):

Plasma Protein ◽

Protein A ◽

First Trimester ◽

Maternal Serum ◽

Obstetric Complications

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First trimester maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A in pregnancies complicated by diabetes mellitus

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/j.1471-0528.2011.03253.x ◽

2012 ◽

Vol 119 (4) ◽

pp. 410-416 ◽

Cited By ~ 29

Author(s):

MD Savvidou ◽

A Syngelaki ◽

M Muhaisen ◽

E Emelyanenko ◽

KH Nicolaides

Keyword(s):

Diabetes Mellitus ◽

Chorionic Gonadotropin ◽

Plasma Protein ◽

Human Chorionic Gonadotropin ◽

Protein A ◽

First Trimester ◽

Maternal Serum ◽

Serum Free

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Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimester Down syndrome screening

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.06.045 ◽

2013 ◽

Vol 100 (5) ◽

pp. 1314-1320.e3 ◽

Cited By ~ 22

Author(s):

José Bellver ◽

Cristina Casanova ◽

Nicolás Garrido ◽

Coral Lara ◽

José Remohí ◽

...

Keyword(s):

Down Syndrome ◽

Plasma Protein ◽

False Positive ◽

Protein A ◽

First Trimester ◽

Maternal Serum ◽

Additive Effect ◽

Assisted Conception ◽

Down Syndrome Screening

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The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03171-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Anni Lehikoinen ◽

Raimo Voutilainen ◽

Jarkko Romppanen ◽

Seppo Heinonen

Keyword(s):

Protein A ◽

Serum Levels ◽

First Trimester ◽

Nuchal Translucency ◽

Maternal Serum ◽

Drug Abusers ◽

Alcohol Abusers ◽

Trimester Screening ◽

Alcohol And Drug Abuse ◽

Β Hcg

Abstract Background The purpose of this study was to determine whether first trimester trisomy screening (FTS) parameters are affected by alcohol and drug use. Methods A routine combined FTS including measurements of maternal serum levels of free β-human chorionic gonadotropin subunit (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) were measured at 9–11 weeks of gestation, and fetal nuchal translucency thickness (NTT) at 11–13 weeks of gestation. In total 544 women with singleton pregnancies [71 alcohol and drug abusers, 88 smokers, 168 non-smokers delivering a small for gestational age (SGA) child, and 217 unexposed control women] were assessed. Results Free β-hCG levels were higher in alcohol and drug abusing than in unexposed pregnant women [mean 1.5 vs. 1.2 multiples of medians (MoM); P = 0.013]. However, stepwise multiple linear regression analyses suggested that smoking could explain increased free β-hCG. Additionally, we observed lower PAPP-A levels in the smoking mothers (0.9 vs. 1.2 MoM; P = 0.045) and in those giving birth to an SGA child compared to the controls (1.1 vs.. 1.2 MoM; P < 0.001). Fetal NTT did not differ significantly between any of the groups. Conclusions The present study shows increased free β-hCG levels in alcohol and drug abusers, but maternal smoking may explain the result. Maternal serum PAPP-A levels were lower in smoking than non-smoking mothers, and in mothers delivering an SGA child. However, FTS parameters (PAPP-A, free β-hCG and NTT) seem not to be applicable for the use as alcohol biomarkers because of their clear overlap between alcohol abusers and healthy controls.

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Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight

Pediatric Research ◽

10.1038/s41390-019-0720-1 ◽

2019 ◽

Vol 87 (6) ◽

pp. 1093-1099 ◽

Cited By ~ 7

Author(s):

Sverre Wikström ◽

Ping-I Lin ◽

Christian H. Lindh ◽

Huan Shu ◽

Carl-Gustaf Bornehag

Keyword(s):

Birth Weight ◽

Prenatal Exposure ◽

Gestational Age ◽

Placental Transfer ◽

Serum Levels ◽

First Trimester ◽

Maternal Serum ◽

Perfluoroalkyl Substances ◽

Perfluorodecanoic Acid ◽

Mother And Child

Abstract Background Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. Methods Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. Results Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93–142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. Conclusions We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.

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