scholarly journals Protein tyrosine phosphatase 1B inhibitory activities of compounds isolated from Polygonum cuspidatum

2019 ◽  
Vol 57 (4) ◽  
pp. 496-499
Author(s):  
Le Hong Luyen ◽  
Pham Minh Quan ◽  
Nguyen Phi Hung
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Polygonum Cuspidatum ◽  
Protein Tyrosine ◽  
Inhibitory Activities

scholarly journals Glucose Uptake Stimulatory and PTP1B Inhibitory Activities of Pimarane Diterpenes from Orthosiphon stamineus Benth

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 859 ◽  
Author(s):  
Phi Hung Nguyen ◽  
Huynh Nhu Tuan ◽  
Duc Thuan Hoang ◽  
Quoc Trung Vu ◽  
Minh Quan Pham ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Insulin Signaling ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Orthosiphon Stamineus ◽  
Potent Inhibition ◽  
Ic50 Values ◽  
Inhibitory Activities

Seven pimarane diterpenes (1–7) were isolated from Orthosiphon stamineus Benth. by assay-guided isolation. All of the isolates possessed a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)-d-glucose uptake effect in 3T3-L1 adipocytes at concentrations of 5 and 10 μM. Most of them showed potent inhibition against protein tyrosine phosphatase 1B with IC50 values ranging from 0.33 to 9.84 μM. In the kinetic study, all inhibition types were exposed for the examined potencies, including mixed-competitive (1), non-competitives (3 and 5), competitive (6), and uncompetitive (7). The results suggested that O. stamineus and its pimarane diterpenes might exert the hypoglycemic effect via the insulin signaling pathway targeting inhibition of protein tyrosine phosphatase 1B (PTP1B) activity.

Triterpenoids and a sterol from the stem-bark ofStyrax japonicaand their protein tyrosine phosphatase 1B inhibitory activities

2008 ◽  
Vol 22 (10) ◽  
pp. 1303-1306 ◽  
Author(s):  
Joo-Hee Kwon ◽  
Min-Jung Chang ◽  
Hyo-Won Seo ◽  
Jeong-Hun Lee ◽  
Byung-Sun Min ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Stem Bark ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Inhibitory Activities
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