Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities

2010 ◽  
Vol 20 (18) ◽  
pp. 5398-5401 ◽  
Author(s):  
Songpei Li ◽  
Wei Li ◽  
Yinghua Wang ◽  
Yoshihisa Asada ◽  
Kazuo Koike
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Glycyrrhiza Uralensis ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Inhibitory Activities

Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors

RSC Advances ◽  
2015 ◽  
Vol 5 (56) ◽  
pp. 45258-45265 ◽  
Author(s):  
Shuai Ji ◽  
Xue Qiao ◽  
Zi-wei Li ◽  
Yong-rui Wang ◽  
Si-wang Yu ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Glycyrrhiza Uralensis ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Ptp1b Inhibitors ◽  
The Absolute

Four new PTP1B inhibitors were isolated from Glycyrrhiza uralensis, and the absolute configuration of 2,3-dihydro-2,3,3-trimethylbenzofurans was first unambiguously established.

scholarly journals Glucose Uptake Stimulatory and PTP1B Inhibitory Activities of Pimarane Diterpenes from Orthosiphon stamineus Benth

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 859 ◽  
Author(s):  
Phi Hung Nguyen ◽  
Huynh Nhu Tuan ◽  
Duc Thuan Hoang ◽  
Quoc Trung Vu ◽  
Minh Quan Pham ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Insulin Signaling ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Orthosiphon Stamineus ◽  
Potent Inhibition ◽  
Ic50 Values ◽  
Inhibitory Activities

Seven pimarane diterpenes (1–7) were isolated from Orthosiphon stamineus Benth. by assay-guided isolation. All of the isolates possessed a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)-d-glucose uptake effect in 3T3-L1 adipocytes at concentrations of 5 and 10 μM. Most of them showed potent inhibition against protein tyrosine phosphatase 1B with IC50 values ranging from 0.33 to 9.84 μM. In the kinetic study, all inhibition types were exposed for the examined potencies, including mixed-competitive (1), non-competitives (3 and 5), competitive (6), and uncompetitive (7). The results suggested that O. stamineus and its pimarane diterpenes might exert the hypoglycemic effect via the insulin signaling pathway targeting inhibition of protein tyrosine phosphatase 1B (PTP1B) activity.

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