scholarly journals Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond

2010 ◽  
Vol 1 (3) ◽  
pp. 494-501 ◽  
Author(s):  
Clinton C. MacDonald ◽  
K. Wyatt McMahon
Keyword(s):  
Alternative Polyadenylation ◽  
Tissue Specific

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites

1984 ◽  
Vol 4 (10) ◽  
pp. 2151-2160
Author(s):  
S G Amara ◽  
R M Evans ◽  
M G Rosenfeld
Keyword(s):  
Regulation Of Gene Expression ◽  
Alternative Polyadenylation ◽  
Calcitonin Gene Related Peptide ◽  
Transcription Unit ◽  
Specific Expression ◽  
Tissue Specific ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Polyadenylation Sites ◽  
Specific Regulation

Different 3' coding exons in the rat calcitonin gene are used to generate distinct mRNAs encoding either the hormone calcitonin in thyroidal C-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue, indicating the RNA processing regulation is one strategy used in tissue-specific regulation of gene expression in the brain. Although the two mRNAs use the same transcriptional initiation site and have identical 5' terminal sequences, their 3' termini are distinct. The polyadenylation sites for calcitonin and calcitonin gene-related peptide mRNAs are located at the end of the exons 4 and 6, respectively. Termination of transcription after the calcitonin exon does not dictate the production of calcitonin mRNA, because transcription proceeds through both calcitonin and calcitonin gene-related peptide exons irrespective of which mRNA is ultimately produced. In isolated nuclei, both polyadenylation sites appear to be utilized; however, the proximal (calcitonin) site is preferentially used in nuclei from tissues producing calcitonin mRNA. These data suggest that the mechanism dictating production of each mRNA involves the selective use of alternative polyadenylation sites.

scholarly journals TSAPA: identification of tissue-specific alternative polyadenylation sites in plants

2018 ◽  
Vol 34 (12) ◽  
pp. 2123-2125 ◽  
Author(s):  
Guoli Ji ◽  
Moliang Chen ◽  
Wenbin Ye ◽  
Sheng Zhu ◽  
Congting Ye ◽  
...  
Keyword(s):  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Alternative ◽  
Polyadenylation Sites

scholarly journals Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila

Cell Reports ◽  
2013 ◽  
Vol 3 (3) ◽  
pp. 969 ◽  
Author(s):  
Peter Smibert ◽  
Pedro Miura ◽  
Jakub O. Westholm ◽  
Sol Shenker ◽  
Gemma May ◽  
...  
Keyword(s):  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Alternative ◽  
Global Patterns

The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression

2013 ◽  
Vol 40 (12) ◽  
pp. 6685-6690 ◽  
Author(s):  
Lyudmila V. Dergunova ◽  
Alexandra V. Rozhkova ◽  
Olga Yu. Sudarkina ◽  
Svetlana A. Limborska
Keyword(s):  
Gene Expression ◽  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Regulation

scholarly journals Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila

Cell Reports ◽  
2012 ◽  
Vol 1 (3) ◽  
pp. 277-289 ◽  
Author(s):  
Peter Smibert ◽  
Pedro Miura ◽  
Jakub O. Westholm ◽  
Sol Shenker ◽  
Gemma May ◽  
...  
Keyword(s):  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Alternative ◽  
Global Patterns

scholarly journals Comparative RNA-Seq analysis reveals pervasive tissue-specific alternative polyadenylation in Caenorhabditis elegans intestine and muscles

BMC Biology ◽  
2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Stephen M Blazie ◽  
Cody Babb ◽  
Henry Wilky ◽  
Alan Rawls ◽  
Jin G Park ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Alternative Polyadenylation ◽  
Rna Seq ◽  
Tissue Specific ◽  
Specific Alternative

scholarly journals Alternative polyadenylation signals and promoters act in concert to control tissue-specific expression of the Opitz Syndrome gene MID1

2007 ◽  
Vol 8 (1) ◽  
pp. 105 ◽  
Author(s):  
Jennifer Winter ◽  
Melanie Kunath ◽  
Stefan Roepcke ◽  
Sven Krause ◽  
Rainer Schneider ◽  
...  
Keyword(s):  
Alternative Polyadenylation ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Control Tissue ◽  
Opitz Syndrome ◽  
Polyadenylation Signals

scholarly journals Use of alternative polyadenylation sites for tissue-specific transcription of two angiotensin-converting enzyme mRNAs

1992 ◽  
Vol 20 (4) ◽  
pp. 683-687 ◽  
Author(s):  
Thomas J. Thekkumkara ◽  
William Livingston ◽  
Ravi S. Kumar ◽  
Ganes C. Sen
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Alternative Polyadenylation ◽  
Converting Enzyme ◽  
Tissue Specific ◽  
Polyadenylation Sites
Sign in / Sign up

Export Citation Format

Share Document