The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression

2013 ◽  
Vol 40 (12) ◽  
pp. 6685-6690 ◽  
Author(s):  
Lyudmila V. Dergunova ◽  
Alexandra V. Rozhkova ◽  
Olga Yu. Sudarkina ◽  
Svetlana A. Limborska
Keyword(s):  
Gene Expression ◽  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Regulation

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites

1984 ◽  
Vol 4 (10) ◽  
pp. 2151-2160
Author(s):  
S G Amara ◽  
R M Evans ◽  
M G Rosenfeld
Keyword(s):  
Regulation Of Gene Expression ◽  
Alternative Polyadenylation ◽  
Calcitonin Gene Related Peptide ◽  
Transcription Unit ◽  
Specific Expression ◽  
Tissue Specific ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Polyadenylation Sites ◽  
Specific Regulation

Different 3' coding exons in the rat calcitonin gene are used to generate distinct mRNAs encoding either the hormone calcitonin in thyroidal C-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue, indicating the RNA processing regulation is one strategy used in tissue-specific regulation of gene expression in the brain. Although the two mRNAs use the same transcriptional initiation site and have identical 5' terminal sequences, their 3' termini are distinct. The polyadenylation sites for calcitonin and calcitonin gene-related peptide mRNAs are located at the end of the exons 4 and 6, respectively. Termination of transcription after the calcitonin exon does not dictate the production of calcitonin mRNA, because transcription proceeds through both calcitonin and calcitonin gene-related peptide exons irrespective of which mRNA is ultimately produced. In isolated nuclei, both polyadenylation sites appear to be utilized; however, the proximal (calcitonin) site is preferentially used in nuclei from tissues producing calcitonin mRNA. These data suggest that the mechanism dictating production of each mRNA involves the selective use of alternative polyadenylation sites.

Tissue-Specific Regulation of Renin-Binding Protein Gene Expression in Rats1

1992 ◽  
Vol 112 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Masazumi Tada ◽  
Saori Takahashi ◽  
Motoshige Miyano ◽  
Yoshihiro Miyake
Keyword(s):  
Gene Expression ◽  
Protein Gene ◽  
Binding Protein ◽  
Tissue Specific ◽  
Binding Protein Gene ◽  
Specific Regulation

TISSUE-SPECIFIC REGULATION OF KIBRA GENE EXPRESSION IN NEUROBLASTOMA AND KIDNEY CELLS

2011 ◽  
Vol 29 ◽  
pp. e144
Author(s):  
K. Guske ◽  
M. Herrmann ◽  
M. Schelleckes ◽  
B. Schmitz ◽  
K. Duning ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kidney Cells ◽  
Tissue Specific ◽  
Specific Regulation

Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

2004 ◽  
Vol 286 (6) ◽  
pp. R977-R988 ◽  
Author(s):  
Joachim Fandrey
Keyword(s):  
Gene Expression ◽  
Reproductive Tract ◽  
Fetal Liver ◽  
Hypoxia Inducible Factor ◽  
The Body ◽  
Glycoprotein Hormone ◽  
Tissue Specific ◽  
Specific Regulation ◽  
Main Regulator ◽  
Regulated Gene Expression

Hypoxia-inducible expression of the gene encoding for the glycoprotein hormone erythropoietin (EPO) is the paradigm of oxygen-regulated gene expression. EPO is the main regulator of red blood cell production and more than 100 years of research on the regulation of EPO production have led to the identification of a widespread cellular oxygen sensing mechanism. Central to this signaling cascade is the transcription factor complex hypoxia-inducible factor-1 (HIF-1). Meanwhile, it is known that HIF-1 controls more than 50 oxygen-dependent genes and is now recognized as the main regulator of oxygen homoeostasis in the body. In addition to hypoxic induction, expression of the EPO gene is tightly regulated in a tissue-specific manner. During ontogeny, production of EPO required for erythropoiesis is switched from the fetal liver to the kidneys. Here EPO is mainly synthesized in adulthood. Production of EPO has also been found in organs where it has nonerythropoietic functions: EPO is important for development of the brain and is neuroprotective, whereas it stimulates angiogenesis in the reproductive tract and possibly in other organs. Understanding oxygen and tissue-specific regulation of EPO production is of high relevance for physiology. Moreover, this knowledge might be useful for new therapies to treat human diseases.

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